Folic acid-sulfonamide conjugates as antibacterial agents: design, synthesis and molecular docking studies

• Published in: RSC advances Vol. 1; no. 7; pp. 42983 - 42992
• Main Authors: Shahzad, Shabnam, Qadir, Muhammad Abdul, Ahmed, Mahmood, Ahmad, Saghir, Khan, Muhammad Jadoon, Gulzar, Asad, Muddassar, Muhammad
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 25.11.2020; The Royal Society of Chemistry
• Subjects: Ampicillin; Antiinfectives and antibacterials; Aromatic compounds; Binding; Chemical synthesis; Chemistry; Conjugates; Dihydrofolate reductase; Enzymes; Folic acid; Molecular docking; NMR; Nuclear magnetic resonance; Reductases; Scaffolds; Standard error; Sulfonamides; Trimethoprim

Dihydrofolate reductase (DHFR) inhibitors, as antibacterial agents, contain pyrimidine, pteridine, and azine moieties among many other scaffolds. Folic acid (FA), with a pteridine ring and amine group, was used as our focus scaffold, which was then conjugated with sulfonamides to develop new conjuga...