Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis

• Published in: Kidney international Vol. 57; no. 6; pp. 2412 - 2422
• Main Authors: Schwarting, Andreas, Hagen, Daniela, Odenthal, Margarethe, Brockmann, Holger, Dienes, Hans-Peter, Wandel, Eveline, Rumpelt, Hans-Joachim, Zum Büschenfelde, Karl-Herrmann Meyer, Galle, Peter Robert, Mayet, Werner
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2000; Elsevier Limited
• Subjects: Adult; Aged; ANCA; Biopsy; Cells, Cultured; crescent glomerulonephritis; Epithelial Cells - metabolism; Female; Granulomatosis with Polyangiitis - metabolism; Granulomatosis with Polyangiitis - pathology; Humans; Kidney - metabolism; Kidney - pathology; Kidney Glomerulus - metabolism; Kidney Glomerulus - pathology; kidney parenchymal cells; Kidney Tubules - metabolism; Kidney Tubules - pathology; Male; Middle Aged; Myeloblastin; rapidly progressive glomerulonephritis; RNA, Messenger - metabolism; Serine Endopeptidases - genetics; vasculitis; crescent glomerulonephritis; kidney parenchymal cells; rapidly progressive glomerulonephritis; vasculitis; ANCA

Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis. Wegener's granulomatosis (WG) is characterized by systemic vasculitis with crescentic glomerulonephritis (CGN) and circulating autoantibodies directed against neutroph...