Identification of collateral sensitivity and evolutionary landscape of chemotherapy-induced drug resistance using cellular barcoding technology

• Published in: Frontiers in pharmacology Vol. 14; p. 1178489
• Main Authors: Danisik, Nurseda, Yilmaz, Kubra Celikbas, Acar, Ahmet
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.07.2023
• Subjects: cancer; cellular barcoding; collateral sensitivity; colorectal; drug resistance; Pharmacology; cancer; drug resistance; colorectal; collateral sensitivity; cellular barcoding

One of the most significant challenges impeding cancer treatment effectiveness is drug resistance. Combining evolutionary understanding with drug resistance can pave the way for the identification of second-line drug options that can overcome drug resistance. Although capecitabine and irinotecan are...