Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-γ and Granzyme B

• Published in: Frontiers in immunology Vol. 14; p. 1158883
• Main Authors: Wu, Meiyu, Wang, Lu, Wu, Haijing, Yang, Ming, He, Zhenghao, Chen, Yiran, Zhang, Huiming
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.05.2023
• Subjects: Animals; autoimmune disease; CD8+ T cells; CD8-Positive T-Lymphocytes; Granzymes - metabolism; Immunology; Interferon-gamma - metabolism; Leptin; Leptin - metabolism; Leukocytes, Mononuclear - metabolism; lipid metabolism; Mice; Vitiligo; vitiligo; CD8+ T cells; autoimmune disease; Leptin; lipid metabolism

Vitiligo is an autoimmune skin disease mainly mediated by CD8 T cells, which affects about 0.1%-2% population of the world. plays a critical role in regulating the activation of CD8 T cells. However, the effect of on vitiligo remains unclear. To explore the effect of leptin on CD8 T cells and its in...