Optimizing the Targeting of Mouse Parvovirus 1 to Murine Melanoma Selects for Recombinant Genomes and Novel Mutations in the Viral Capsid Gene

• Published in: Viruses Vol. 10; no. 2; p. 54
• Main Authors: Marr, Matthew, D’Abramo, Anthony, Pittman, Nikea, Agbandje-McKenna, Mavis, Cotmore, Susan, Tattersall, Peter
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.01.2018; MDPI
• Subjects: Amino acid sequence; Cell surface; chimera; Chimeras; Cloning; Coat protein; enhancement; Genomes; Homology; Immunogenicity; Immunomodulation; Infections; Infectivity; Melanoma; Mutation; oncotropic; Parvoviruses; protoparvovirus; recombination; selection; structure; targeting; Viruses; chimera; oncotropic; mutation; protoparvovirus; targeting; recombination; selection; melanoma; enhancement; structure

Combining virus-enhanced immunogenicity with direct delivery of immunomodulatory molecules would represent a novel treatment modality for melanoma, and would require development of new viral vectors capable of targeting melanoma cells preferentially. Here we explore the use of rodent protoparvovirus...