Brincidofovir Is Not a Substrate for the Human Organic Anion Transporter 1: A Mechanistic Explanation for the Lack of Nephrotoxicity Observed in Clinical Studies - Tippin, Timothy K; Morrison, Marion E; Brundage, Thomas M; Momméja-Marin, Hervé (Therapeutic drug monitoring, 2016)
Keywords: Adolescent; Adult; Aged; Animals; Antiviral Agents - adverse effects; Antiviral Agents - pharmacokinetics; Biological Transport - physiology; Cell Line; Child; Cytosine - adverse effects; Cytosine - analogs & derivatives; Cytosine - pharmacokinetics; Dogs; Female; Glomerular Filtration Rate - drug effects; Humans; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - metabolism; Madin Darby Canine Kidney Cells; Male; Middle Aged; Organic Anion Transport Protein 1 - metabolism; Organophosphonates - adverse effects; Organophosphonates - pharmacokinetics; Young Adult