A critical view on conservative mutations

• Published in: Protein engineering Vol. 14; no. 6; pp. 397 - 402
• Main Authors: Jonson, P H, Petersen, S B
• Format: Journal Article
• Language: English
• Published: England Oxford Publishing Limited (England) 01.06.2001
• Subjects: Amino Acid Sequence; Aspartic Acid - chemistry; Glutamic Acid - chemistry; Ions; Models, Molecular; Mutation; Protein Conformation; Sequence Homology, Amino Acid; Solvents - pharmacology; Static Electricity

By analysing the surface composition of a set of protein 3D structures, complemented with predicted surface compositional information for homologous proteins, we have found significant evidence for a layer composition of protein structures. In the innermost and outermost parts of proteins there is a...