A phase I study of autologous mesenchymal stromal cells for severe steroid-dependent nephrotic syndrome

• Published in: JCI insight Vol. 8; no. 18
• Main Authors: Vivarelli, Marina, Colucci, Manuela, Algeri, Mattia, Zotta, Federica, Emma, Francesco, L'Erario, Ines, Busutti, Marco, Rota, Stefano, Capelli, Chiara, Introna, Martino, Todeschini, Marta, Casiraghi, Federica, Perna, Annalisa, Peracchi, Tobia, De Salvo, Andrea, Rubis, Nadia, Locatelli, Franco, Remuzzi, Giuseppe, Ruggenenti, Piero
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 22.09.2023; American Society for Clinical investigation
• Subjects: Child; Clinical Medicine; Clinical trials; Glucocorticoids - therapeutic use; Humans; Immunosuppression Therapy; Mesenchymal Stem Cells; Nephrology; Nephrotic Syndrome - therapy; Recurrence; Young Adult; Clinical Trials; Nephrology; Immunotherapy

BACKGROUNDSevere forms of idiopathic nephrotic syndrome (INS) require prolonged immunosuppressive therapies and repeated courses of high-dose glucocorticoids. Mesenchymal stromal cells (MSCs) have promising immunomodulatory properties that may be employed therapeutically to reduce patient exposure t...