SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells

• Published in: Microbes and infection Vol. 5; no. 7; pp. 561 - 570
• Main Authors: Coombes, Brian K., Brown, Nat F., Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B.Brett
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.06.2003; Amsterdam Elsevier; Paris
• Subjects: Animals; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Genes, Bacterial; HeLa Cells; Humans; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; Microbiology; Molecular Chaperones - genetics; Molecular Chaperones - physiology; Mutation; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Protein Transport; Salmonella - metabolism; Salmonella - pathogenicity; Salmonella enterica serovar Typhimurium; Salmonella Infections, Animal - microbiology; Salmonella pathogenicity island-2; Type III secretion; Virulence factor; Virulence Factors - physiology; Salmonella pathogenicity island-2; Salmonella enterica serovar Typhimurium; Type III secretion; Virulence factor; Secretion; Virulence; Pathogenicity island; Salmonella typhimurium; Mechanism; Pathogenicity; Bacteria; Attenuated strain; Enterobacteriaceae

The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine model of systemic infection were used to address the role of an uncharacterized SPI2 open reading fr...