ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

• Published in: Scientific reports Vol. 2; no. 1; p. 809
• Main Authors: Barcia, Carlos, Ros, Carmen María, Annese, Valentina, Carrillo-de Sauvage, María Angeles, Ros-Bernal, Francisco, Gómez, Aurora, Yuste, José Enrique, Campuzano, Carmen María, de Pablos, Vicente, Fernandez-Villalba, Emiliano, Herrero, María Trinidad
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 08.11.2012
• Subjects: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology; Actin Cytoskeleton - physiology; Animals; cdc42 GTP-Binding Protein - antagonists & inhibitors; cdc42 GTP-Binding Protein - metabolism; Cdc42 protein; Cell body; Cell Size; Dopamine receptors; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - physiology; Filopodia; Golgi apparatus; Golgi Apparatus - physiology; Intoxication; Mice; Mice, Inbred C57BL; Microglia; Microglia - drug effects; Microglia - physiology; Motility; Movement disorders; MPTP; MPTP Poisoning - chemically induced; MPTP Poisoning - metabolism; MPTP Poisoning - pathology; Neurodegeneration; Neurodegenerative diseases; Neuronal-glial interactions; Neurons; Parkinson's disease; Phagocytes; Phagocytosis; Phagocytosis - drug effects; Polarization; rho-Associated Kinases - antagonists & inhibitors; rho-Associated Kinases - metabolism; Rodents

The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimental mouse model of Parkinson's disease following the intraperitoneal injection of MPTP...