Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study

• Published in: Acta diabetologica Vol. 48; no. 1; pp. 61 - 69
• Main Authors: Kong, Lei, Zhu, Junjie, Han, Wenxia, Jiang, Xiuyun, Xu, Min, Zhao, Yue, Dong, Qiongzhu, Pang, Zengfen, Guan, Qingbo, Gao, Ling, Zhao, Jiajun, Zhao, Lei
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.03.2011; Springer Nature B.V
• Subjects: Adult; Blood Glucose - analysis; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Female; Gene expression; Glucose; Glucose Tolerance Test; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Metabolic Diseases; MicroRNAs - blood; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Original Article; Pathogenesis; Prediabetic State - blood; Prediabetic State - genetics; Prediabetic State - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; Up-Regulation; Impaired glucose tolerance (IGT); Type 2 diabetes (T2D); Normal glucose tolerance (NGT); Circulating MicroRNA; Impaired fasting glucose (IFG)

To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 diabetes (T2D), 56 subjects were recruited to this study: 18 cases of newly diagnosed T2D (n-T2D) patients, 19 cases of pre...