Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion

• Published in: Diabetes (New York, N.Y.) Vol. 64; no. 3; pp. 733 - 745
• Main Authors: Michailidou, Zoi, Morton, Nicholas M., Moreno Navarrete, José Maria, West, Christopher C., Stewart, Kenneth J., Fernández-Real, José Manuel, Schofield, Christopher J., Seckl, Jonathan R., Ratcliffe, Peter J.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.03.2015
• Subjects: Adipocytes - metabolism; Adipose Tissue - cytology; Adipose Tissue - metabolism; Adult; Animals; Fatty Acids, Nonesterified - metabolism; Female; Homeostasis; Hormones; Humans; Hypoxia; Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism; Immunoblotting; Immunohistochemistry; Lipase - metabolism; Lipids; Lipolysis - physiology; Male; Metabolism; Mice; Middle Aged; Proteins; Ribonucleic acid; RNA; Rodents

Prolyl hydroxylase enzymes (PHDs) sense cellular oxygen upstream of hypoxia-inducible factor (HIF) signaling, leading to HIF degradation in normoxic conditions. In this study, we demonstrate that adipose PHD2 inhibition plays a key role in the suppression of adipocyte lipolysis. Adipose Phd2 gene ab...