LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCη Axis

• Published in: Frontiers in immunology Vol. 14; p. 1225482
• Main Authors: Wang, Huifang, Li, Yichen, Jiang, Shuqi, Liu, Nan, Zhou, Qiuping, Li, Qian, Chen, Zhuo, Lin, Yiyan, Chen, Chunbo, Deng, Yiyu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.12.2023
• Subjects: astrocytes; Immunology; lncRNA XIST; microglia; miR-122-5p; sepsis; sepsis associated neuroinflammation; lncRNA XIST; intracranial infection; miR-122-5p; astrocytes; sepsis associated neuroinflammation; microglia; sepsis

Neuroinflammation is a common feature of many neurological diseases, and remains crucial for disease progression and prognosis. Activation of microglia and astrocytes can lead to neuroinflammation. However, little is known about the role of lncRNA xist and miR-122-5p in the pathogenesis of sepsis-as...