Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats

• Published in: Viruses Vol. 14; no. 4; p. 669
• Main Authors: Fu, Yu, Lorrai, Irene, Zorman, Barry, Mercatelli, Daniele, Shankula, Chase, Marquez Gaytan, Jorge, Lefebvre, Celine, de Guglielmo, Giordano, Kim, Hyunjae Ryan, Sumazin, Pavel, Giorgi, Federico M., Repunte-Canonigo, Vez, Sanna, Pietro Paolo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.03.2022; MDPI
• Subjects: Adaptation; AIDS; Analgesics, Opioid - adverse effects; Animals; Catheters; Cognitive ability; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - complications; cognitive impairment; Drug abuse; Drug dosages; Drug use; Gene expression; Glucocorticoids; HIV; HIV Infections - complications; Human immunodeficiency virus; Humans; Immune system; Inflammation; Intubation; Kinases; Laboratory animals; Narcotics; Neurodegeneration; neuroHIV; neuroinflammation; Neurotoxicity; Opioids; Oxycodone; Oxycodone - adverse effects; Pattern recognition; Prefrontal cortex; Prescription drugs; Rats; Rats, Transgenic; Self-administration; Transcription; United States > US; AIDS; cognitive impairment; neuroinflammation; neuroHIV

Substance use disorder is associated with accelerated disease progression in people with human immunodeficiency virus (HIV; PWH). Problem opioid use, including high-dose opioid therapy, prescription drug misuse, and opioid abuse, is high and increasing in the PWH population. Oxycodone is a broadly p...