Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats - Fu, Yu; Lorrai, Irene; Zorman, Barry; Mercatelli, Daniele; Shankula, Chase; Marquez Gaytan, Jorge; Lefebvre, Celine; de Guglielmo, Giordano; Kim, Hyunjae Ryan; Sumazin, Pavel; Giorgi, Federico M.; Repunte-Canonigo, Vez; et al. (Viruses, 2022)
Keywords: Adaptation; AIDS; Analgesics, Opioid - adverse effects; Animals; Catheters; Cognitive ability; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - complications; cognitive impairment; Drug abuse; Drug dosages; Drug use; Gene expression; Glucocorticoids; HIV; HIV Infections - complications; Human immunodeficiency virus; Humans; Immune system; Inflammation; Intubation; Kinases; Laboratory animals; Narcotics; Neurodegeneration; neuroHIV; neuroinflammation; Neurotoxicity; Opioids; Oxycodone; Oxycodone - adverse effects; Pattern recognition; Prefrontal cortex; Prescription drugs; Rats; Rats, Transgenic; Self-administration; Transcription; United States--US; AIDS; cognitive impairment; neuroinflammation; neuroHIV