Application of the Phage Lysin Ply5218 in the Treatment of Streptococcus suis Infection in Piglets
( ) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant bacteria. Thus, novel antimicrobials against infections are urgently needed. In the previous study, a cell wall hydrolase or lysin derived f...
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Published in | Viruses Vol. 11; no. 8; p. 715 |
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Main Authors | , , , , , , , , , |
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Abstract | (
) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant bacteria. Thus, novel antimicrobials against
infections are urgently needed. In the previous study, a cell wall hydrolase or lysin derived from Streptococcus prophage phi5218, termed Ply5218, was identified. This lysin showed strong bacteriolytic activity against
. In the current study, the in vitro data showed that after incubation with pig serum, the bacteriolytic efficacy of Ply5218 declined in a time-dependent manner. The in vivo assays indicated that a Ply5218 triple treatment (6, 24, and 48 h post infection) was effective against various serotypes of
in a murine infection model. This regimen also alleviated streptococcal-induced clinical symptoms in piglets and significantly reduced the bacterial burden and levels of interleukin 6, a proinflammatory cytokine. This study indicates that Ply5218 shows strong antibacterial activity in pigs and has the potential to be used as a treatment for infectious diseases caused by
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AbstractList | Streptococcus suis (S. suis) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant bacteria. Thus, novel antimicrobials against S. suis infections are urgently needed. In the previous study, a cell wall hydrolase or lysin derived from Streptococcus prophage phi5218, termed Ply5218, was identified. This lysin showed strong bacteriolytic activity against S. suis. In the current study, the in vitro data showed that after incubation with pig serum, the bacteriolytic efficacy of Ply5218 declined in a time-dependent manner. The in vivo assays indicated that a Ply5218 triple treatment (6, 24, and 48 h post infection) was effective against various serotypes of S. suis in a murine infection model. This regimen also alleviated streptococcal-induced clinical symptoms in piglets and significantly reduced the bacterial burden and levels of interleukin 6, a proinflammatory cytokine. This study indicates that Ply5218 shows strong antibacterial activity in pigs and has the potential to be used as a treatment for infectious diseases caused by S. suis. Streptococcus suis ( S. suis ) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant bacteria. Thus, novel antimicrobials against S. suis infections are urgently needed. In the previous study, a cell wall hydrolase or lysin derived from Streptococcus prophage phi5218, termed Ply5218, was identified. This lysin showed strong bacteriolytic activity against S. suis . In the current study, the in vitro data showed that after incubation with pig serum, the bacteriolytic efficacy of Ply5218 declined in a time-dependent manner. The in vivo assays indicated that a Ply5218 triple treatment (6, 24, and 48 h post infection) was effective against various serotypes of S. suis in a murine infection model. This regimen also alleviated streptococcal-induced clinical symptoms in piglets and significantly reduced the bacterial burden and levels of interleukin 6, a proinflammatory cytokine. This study indicates that Ply5218 shows strong antibacterial activity in pigs and has the potential to be used as a treatment for infectious diseases caused by S. suis . ( ) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant bacteria. Thus, novel antimicrobials against infections are urgently needed. In the previous study, a cell wall hydrolase or lysin derived from Streptococcus prophage phi5218, termed Ply5218, was identified. This lysin showed strong bacteriolytic activity against . In the current study, the in vitro data showed that after incubation with pig serum, the bacteriolytic efficacy of Ply5218 declined in a time-dependent manner. The in vivo assays indicated that a Ply5218 triple treatment (6, 24, and 48 h post infection) was effective against various serotypes of in a murine infection model. This regimen also alleviated streptococcal-induced clinical symptoms in piglets and significantly reduced the bacterial burden and levels of interleukin 6, a proinflammatory cytokine. This study indicates that Ply5218 shows strong antibacterial activity in pigs and has the potential to be used as a treatment for infectious diseases caused by . |
Author | Wang, Jian Wang, Zhaofei Wang, Hengan Ma, Jingjiao Kong, Licheng Yan, Yaxian Cheng, Yuqiang Yang, Denghui Fu, Qiang Sun, Jianhe |
AuthorAffiliation | 2 Shanghai Animal Disease Control Centre, Shanghai 201103, China 1 Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
AuthorAffiliation_xml | – name: 2 Shanghai Animal Disease Control Centre, Shanghai 201103, China – name: 1 Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
Author_xml | – sequence: 1 givenname: Zhaofei surname: Wang fullname: Wang, Zhaofei organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China – sequence: 2 givenname: Jingjiao orcidid: 0000-0003-1187-7249 surname: Ma fullname: Ma, Jingjiao organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China – sequence: 3 givenname: Jian surname: Wang fullname: Wang, Jian organization: Shanghai Animal Disease Control Centre, Shanghai 201103, China – sequence: 4 givenname: Denghui surname: Yang fullname: Yang, Denghui organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China – sequence: 5 givenname: Licheng surname: Kong fullname: Kong, Licheng organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China – sequence: 6 givenname: Qiang surname: Fu fullname: Fu, Qiang organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China – sequence: 7 givenname: Yuqiang surname: Cheng fullname: Cheng, Yuqiang organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China – sequence: 8 givenname: Hengan surname: Wang fullname: Wang, Hengan organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China – sequence: 9 givenname: Yaxian surname: Yan fullname: Yan, Yaxian email: yanyaxian@sjtu.edu.cn organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. yanyaxian@sjtu.edu.cn – sequence: 10 givenname: Jianhe surname: Sun fullname: Sun, Jianhe email: sunjhe@sjtu.edu.cn organization: Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. sunjhe@sjtu.edu.cn |
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CitedBy_id | crossref_primary_10_1093_jac_dkad006 crossref_primary_10_3390_antibiotics13040294 crossref_primary_10_3390_v14091996 crossref_primary_10_1016_j_copbio_2021_01_012 crossref_primary_10_1186_s13567_022_01111_3 crossref_primary_10_3390_molecules26051419 crossref_primary_10_1016_j_micres_2021_126746 crossref_primary_10_1080_21645515_2023_2175519 crossref_primary_10_1111_1541_4337_12757 crossref_primary_10_3390_v12020210 crossref_primary_10_1007_s00203_023_03503_1 |
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) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant... Streptococcus suis (S. suis) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the... Streptococcus suis ( S. suis ) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the... |
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SubjectTerms | Antibacterial activity Antibiotic resistance Antibiotics Antimicrobial agents Bacterial infections Cell walls E coli Hogs Hydrolase infection Infections Infectious diseases Inflammation Interleukin 6 Laboratories lysin Pathogens Phages piglet Proteins Serotypes Spleen Streptococcus infections Streptococcus suis treatment Viral infections |
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Title | Application of the Phage Lysin Ply5218 in the Treatment of Streptococcus suis Infection in Piglets |
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