Differential effects of allopregnanolone and diazepam on social behavior through modulation of neural oscillation dynamics in basolateral amygdala and medial prefrontal cortex

• Published in: Frontiers in cellular neuroscience Vol. 18; p. 1404603
• Main Authors: Yawata, Yosuke, Tashima, Ryoichi, Aritomi, Hiroyuki, Shimada, Shinji, Onodera, Tsukasa, Taishi, Teruhiko, Takasu, Keiko, Ogawa, Koichi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.06.2024
• Subjects: antidepressant-like effect; benzodiazepine; Cellular Neuroscience; extrasynaptic GABAA receptor; neuroactive steroid; social defeat stress model; theta activity; social defeat stress model; antidepressant-like effect; basolateral amygdala; benzodiazepine; extrasynaptic GABAA receptor; neuroactive steroid; theta activity

Effective treatments for major depressive disorder (MDD) have long been needed. One hypothesis for the mechanism of depression involves a decrease in neuroactive steroids such as allopregnanolone, an endogenous positive allosteric modulator of the γ-aminobutyric acid–gated chloride channel (GABA A )...