Serum antibody fingerprinting of SARS-CoV-2 variants in infected and vaccinated subjects by label-free microarray biosensor

• Published in: Frontiers in immunology Vol. 15; p. 1323406
• Main Authors: Carzaniga, Thomas, Casiraghi, Luca, Nava, Giovanni, Zanchetta, Giuliano, Inzani, Tommaso, Chiari, Marcella, Bollati, Valentina, Epis, Sara, Bandi, Claudio, Lai, Alessia, Zehender, Gianguglielmo, Bellini, Tommaso, Buscaglia, Marco
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.02.2024
• Subjects: antibody repertoire; Immunology; label-free biosensor; rapid detection; reflective phantom interface; serological assay; wash-free assay; wash-free assay; IgA; label-free biosensor; reflective phantom interface; rapid detection; immunoglobulins; serological assay; antibody repertoire

Both viral infection and vaccination affect the antibody repertoire of a person. Here, we demonstrate that the analysis of serum antibodies generates information not only on the virus type that caused the infection but also on the specific virus variant. We developed a rapid multiplex assay providin...