Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose–response meta-analysis of prospective studies

• Published in: Annals of oncology Vol. 23; no. 4; pp. 843 - 852
• Main Authors: Aune, D., Greenwood, D.C., Chan, D.S.M., Vieira, R., Vieira, A.R., Navarro Rosenblatt, D.A., Cade, J.E., Burley, V.J., Norat, T.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.2012; Oxford University Press
• Subjects: Antineoplastic agents; Biological and medical sciences; Body Mass Index; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Incidence; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; meta-analysis; Obesity, Abdominal - complications; Obesity, Abdominal - epidemiology; Obesity, Abdominal - mortality; pancreatic cancer; Pancreatic Neoplasms - epidemiology; Pancreatic Neoplasms - etiology; Pancreatic Neoplasms - mortality; Pharmacology. Drug treatments; Prospective Studies; Regression Analysis; Risk Factors; systematic review; Tumors; waist circumference; Waist-Hip Ratio; waist-to-hip ratio; meta-analysis; waist-to-hip ratio; pancreatic cancer; systematic review; waist circumference; body mass index; Systematic review; Corporal biometry; Malignant tumor; Review; Hip; Abdomen; Metaanalysis; Dose activity relation; Prospective; Body mass index; Waist circumference; Pancreas cancer; Risk factor; Digestive diseases; Ratio; Cancer; Pancreatic disease

Questions remain about the shape of the dose–response relationship between body mass index (BMI) and pancreatic cancer risk, possible confounding by smoking, and differences by gender or geographic location. Whether abdominal obesity increases risk is unclear. We conducted a systematic review and me...