Characterizing Phage Genomes for Therapeutic Applications

• Published in: Viruses Vol. 10; no. 4; p. 188
• Main Authors: Philipson, Casandra W, Voegtly, Logan J, Lueder, Matthew R, Long, Kyle A, Rice, Gregory K, Frey, Kenneth G, Biswas, Biswajit, Cer, Regina Z, Hamilton, Theron, Bishop-Lilly, Kimberly A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.04.2018; MDPI
• Subjects: Alcohol; Antibiotics; Antimicrobial agents; Bacterial infections; Bacteriophages - classification; Bacteriophages - genetics; Bacteriophages - isolation & purification; Bacteriophages - physiology; best practices; Contamination; Drug development; Drug resistance; Enzymes; FDA approval; Genes; Genetic engineering; Genome, Viral - genetics; Genomes; Genomics; Guidelines as Topic; high-throughput sequencing; Humans; IND; Infections; Laboratories; Lifestyles; Multidrug resistance; Next-generation sequencing; phage therapy; Phage Therapy - standards; Phages; Phenols; Phylogeny; Pipelines; Reproducibility of Results; Safety; Therapeutic applications; Toxins; viral genomes; Virulence; Workflow; United States > US; viral genomes; IND; high-throughput sequencing; best practices; phage therapy

Multi-drug resistance is increasing at alarming rates. The efficacy of phage therapy, treating bacterial infections with bacteriophages alone or in combination with traditional antibiotics, has been demonstrated in emergency cases in the United States and in other countries, however remains to be ap...