Brain functional alterations observed 4-weekly in major depressive disorder following antidepressant treatment

• Published in: Journal of affective disorders Vol. 252; pp. 25 - 31
• Main Authors: Yamagata, Bun, Yamanaka, Kaori, Takei, Yuichi, Hotta, Shogo, Hirano, Jinichi, Tabuchi, Hajime, Mimura, Masaru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2019
• Subjects: Adult; Antidepressant treatment; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Depression; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - metabolism; Female; Hemodynamics - drug effects; Humans; Longitudinal Studies; Longitudinal study; Male; Near-infrared spectroscopy; Neuroimaging; Oxyhemoglobins - metabolism; Prefrontal Cortex - blood supply; Psychiatric Status Rating Scales; Sertraline; Sertraline - pharmacology; Sertraline - therapeutic use; Spectroscopy, Near-Infrared; Time Factors; Treatment Outcome; Young Adult; Neuroimaging; DMN; VFT; Longitudinal study; rs-fMRI; Depression; Antidepressant treatment; oxy-Hb; MDD; Sertraline; Near-infrared spectroscopy; total-Hb; ANOVA; ECT; NIRS; BOLD; HC; FC; HRS-D; deoxy-Hb; BA

•Despite clinical improvements, hypofrontality in MDD persists after treatment.•Atypical [oxy-Hb] time-course changes were identified throughout 12-week observations.•NIRS signals may be a potential predictor of treatment response in MDD. Major depressive disorder (MDD) is a heterogeneous condition....