Optimizing sheep B-cell epitopes in Echinococcus granulosus recombinant antigen P29 for vaccine development

• Published in: Frontiers in immunology Vol. 15; p. 1451538
• Main Authors: Yang, Jihui, Lv, Yongxue, Zhu, Yazhou, Song, Jiahui, Zhu, Mingxing, Wu, Changyou, Fu, Yong, Zhao, Wei, Zhao, Yinqi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.08.2024
• Subjects: Animals; Antibodies, Helminth - blood; Antibodies, Helminth - immunology; Antigens, Helminth - genetics; Antigens, Helminth - immunology; B cell epitopes; Echinococcosis - immunology; Echinococcosis - prevention & control; Echinococcus granulosus; Echinococcus granulosus - genetics; Echinococcus granulosus - immunology; Epitopes, B-Lymphocyte - immunology; Immunology; recombinant antigen P29; Recombinant Proteins - immunology; Sheep; Sheep Diseases - immunology; Sheep Diseases - parasitology; Sheep Diseases - prevention & control; vaccine; Vaccine Development; Vaccines, Synthetic - immunology; B cell epitopes; recombinant antigen P29; vaccine; sheep; Echinococcus granulosus

is a widespread zoonotic parasitic disease, significantly impacting human health and livestock development; however, no vaccine is currently available for humans. Our preliminary studies indicate that recombinant antigen P29 (rEg.P29) is a promising candidate for vaccine. Sheep were immunized with r...