S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is an Important Determinant of Virulence in Piglets

• Published in: Viruses Vol. 10; no. 9; p. 467
• Main Authors: Suzuki, Tohru, Terada, Yutaka, Enjuanes, Luis, Ohashi, Seiichi, Kamitani, Wataru
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.08.2018; MDPI
• Subjects: Amino acids; Artificial chromosomes; Cloning; coronavirus; Dehydration; Diarrhea; Disease; Epidemics; Genes; Genetics; Genomes; Gnotobiotic; gnotobiotic piglets; Hogs; Mortality; porcine epidemic diarrhea virus; Proteins; Respiratory diseases; reverse genetics; S gene; Spike protein; Transmissible gastroenteritis; Virulence; Viruses; Middle East; United States > US; Europe; China; Japan; Germany; coronavirus; reverse genetics; gnotobiotic piglets; virulence; porcine epidemic diarrhea virus; spike protein

Base on the sequence of S genes, which encode spike proteins, we previously identified three different types (North American, S INDEL, and S large-DEL types) of porcine epidemic diarrhea virus (PEDV) that have re-emerged in Japan since 2013. Based on experimental infections with the North American a...