A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells

• Published in: Immunity (Cambridge, Mass.) Vol. 38; no. 3; pp. 425 - 436
• Main Authors: Ladell, Kristin, Hashimoto, Masao, Iglesias, Maria Candela, Wilmann, Pascal G., McLaren, James E., Gras, Stéphanie, Chikata, Takayuki, Kuse, Nozomi, Fastenackels, Solène, Gostick, Emma, Bridgeman, John S., Venturi, Vanessa, Arkoub, Zaïna Aït, Agut, Henri, van Bockel, David J., Almeida, Jorge R., Douek, Daniel C., Meyer, Laurence, Venet, Alain, Takiguchi, Masafumi, Rossjohn, Jamie, Price, David A., Appay, Victor
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.03.2013; Elsevier Limited
• Subjects: Acquired immune deficiency syndrome; AIDS; Amino Acid Sequence; Antigen Presentation - immunology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - virology; Clone Cells - immunology; Clone Cells - metabolism; Clone Cells - virology; Councils; Crystallography, X-Ray; Drug therapy; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Epitopes, T-Lymphocyte - metabolism; Flow cytometry; HIV; HIV Core Protein p24 - genetics; HIV Core Protein p24 - immunology; HIV Core Protein p24 - metabolism; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - immunology; HIV-1 - metabolism; HLA-B27 Antigen - chemistry; HLA-B27 Antigen - immunology; HLA-B27 Antigen - metabolism; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immune system; Immunodominant Epitopes - chemistry; Immunodominant Epitopes - immunology; Immunodominant Epitopes - metabolism; Infections; Models, Molecular; Molecular Sequence Data; Mutation; Patients; Peptides; Protein Binding - immunology; Protein Structure, Tertiary; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Receptors, Antigen, T-Cell - metabolism; T cell receptors; Vaccines

The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV-1-specific CD8+ T cell responses directed against the immunodominant p24 Gag-derived epitope KK10 (KRWIILGLNK263...