Progestin plus metformin improves outcomes in patients with endometrial hyperplasia and early endometrial cancer more than progestin alone: a meta-analysis

• Published in: Frontiers in endocrinology (Lausanne) Vol. 14; p. 1139858
• Main Authors: Shao, Fengping, Li, Yinguang, Zhao, Yunhe
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.06.2023
• Subjects: cancer; complete response; Endocrinology; Endometrial Hyperplasia - drug therapy; Endometrial Neoplasms - drug therapy; Female; Fertility Preservation - methods; Humans; hyperplasia; metformin; Metformin - therapeutic use; Neoplasm Recurrence, Local; Pregnancy; progestin; Progestins - therapeutic use; relapse; Steroids; progestin; obstetrical outcomes; relapse; complete response; hyperplasia; metformin; cancer

Progestin based therapy is the preferred option for fertility-sparing treatment of reproductive-age women with preserved fertility in endometrial hyperplasia (EH) or early endometrial cancer (EEC). Our objective was to investigate whether metformin could enhance the efficacy of progestin-based thera...