Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat

• Published in: Neuropharmacology Vol. 50; no. 6; pp. 755 - 760
• Main Authors: Swanson, Chad J., Perry, Kenneth W., Koch-Krueger, Susanne, Katner, Jason, Svensson, Kjell A., Bymaster, Frank P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2006
• Subjects: Adrenergic Uptake Inhibitors - pharmacology; Analysis of Variance; Animals; Atomoxetine; Atomoxetine Hydrochloride; Attention deficit/hyperactivity disorder; Brain - drug effects; Dopamine; Dopamine - metabolism; Extracellular Space - drug effects; Male; Microdialysis; Microdialysis - methods; Norepinephrine; Norepinephrine - metabolism; Propylamines - pharmacology; Rats; Rats, Sprague-Dawley; Time Factors; Transporter; Norepinephrine; Dopamine; Microdialysis; Atomoxetine; Transporter; Attention deficit/hyperactivity disorder

Atomoxetine is a selective inhibitor of norepinephrine transporters and is currently being used in the pharmacotherapy of attention deficit/hyperactivity disorder (ADHD). We have previously shown that atomoxetine increased extracellular (EX) concentrations of norepinephrine and dopamine in prefronta...