The role of lutein-rich purple sweet potato leaf extract on the amelioration of diabetic retinopathy in streptozotocin-induced Sprague-Dawley rats

The objective of this study is to access the effect of purple sweet potato leaf (PSPL) extract on diabetic retinopathy (DR) of streptozotocin (STZ)-induced male Sprague-Dawley (SD) rats. In this study, rats were injected intraperitoneally with a single dose of 60 mg/kg STZ, and diabetes was confirme...

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Published inFrontiers in pharmacology Vol. 14; p. 1175907
Main Authors Hisamuddin, Ahmad Safiyyu'd-Din Bin, Naomi, Ruth, Manan, Khairul Aiman Bin, Bahari, Hasnah, Othman, Fezah, Embong, Hashim, Ismail, Amin, Ahmed, Qamar Uddin, Jumidil, Siti Hadizah, Hussain, Mohd Khairi, Zakaria, Zainul Amiruddin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.05.2023
Subjects
antioxidants
cataract
diabetes
Pharmacology
plant
purple sweet potato
retinal changes
cataract
antioxidants
diabetes
purple sweet potato
retinal changes
plant
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Abstract The objective of this study is to access the effect of purple sweet potato leaf (PSPL) extract on diabetic retinopathy (DR) of streptozotocin (STZ)-induced male Sprague-Dawley (SD) rats. In this study, rats were injected intraperitoneally with a single dose of 60 mg/kg STZ, and diabetes was confirmed on day 7. Rats were further divided into a few groups, which were then orally administered with one of the following treatments: 25 mg/kg of gliclazide (D25G), 200 mg/kg of PSPL extract (DT 200), and 400 mg/kg of PSPL extract (DT 400). However, the normal control (NS) and control group for diabetic (DNS) were given normal saline (NS) for 12 weeks. The results show that the treated group demonstrated a reduction in serum oral glucose tolerance test (OGTT) levels of DT 200 and DT 400, and an increase in the serum and retinal insulin levels, and restored oxidative stress markers in serum and retina on week 12. The PSPL extract exhibited protective effects in maintaining the kidney, liver, retina, and pancreas architecture in 400 mg/kg compared to the 200 mg/kg treated group and D25G, thereby restoring fully transparent lenses in diabetes-induced rats. In conclusion, 400 mg/kg PSPL is the most effective dose for the amelioration of STZ-induced DR pathology in male SD rats.
AbstractList The objective of this study is to access the effect of purple sweet potato leaf (PSPL) extract on diabetic retinopathy (DR) of streptozotocin (STZ)-induced male Sprague–Dawley (SD) rats. In this study, rats were injected intraperitoneally with a single dose of 60 mg/kg STZ, and diabetes was confirmed on day 7. Rats were further divided into a few groups, which were then orally administered with one of the following treatments: 25 mg/kg of gliclazide (D25G), 200 mg/kg of PSPL extract (DT 200), and 400 mg/kg of PSPL extract (DT 400). However, the normal control (NS) and control group for diabetic (DNS) were given normal saline (NS) for 12 weeks. The results show that the treated group demonstrated a reduction in serum oral glucose tolerance test (OGTT) levels of DT 200 and DT 400, and an increase in the serum and retinal insulin levels, and restored oxidative stress markers in serum and retina on week 12. The PSPL extract exhibited protective effects in maintaining the kidney, liver, retina, and pancreas architecture in 400 mg/kg compared to the 200 mg/kg treated group and D25G, thereby restoring fully transparent lenses in diabetes-induced rats. In conclusion, 400 mg/kg PSPL is the most effective dose for the amelioration of STZ-induced DR pathology in male SD rats.
Author Embong, Hashim
Hussain, Mohd Khairi
Othman, Fezah
Ahmed, Qamar Uddin
Manan, Khairul Aiman Bin
Hisamuddin, Ahmad Safiyyu'd-Din Bin
Zakaria, Zainul Amiruddin
Ismail, Amin
Jumidil, Siti Hadizah
Naomi, Ruth
Bahari, Hasnah
AuthorAffiliation 1 Borneo Research on Algesia , Inflammation and Neurodegeneration (BRAIN) Group , Faculty of Medicine and Health Sciences , Sabah Universiti Malaysia , Kota Kinabalu , Sabah , Malaysia
4 Department of Emergency Medicine , Faculty of Medicine , Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia
5 Department of Nutrition , Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Malaysia
6 Department of Pharmaceutical Chemistry , Kulliyah of Pharmacy , International Islamic University Malaysia , Kuantan , Pahang , Malaysia
2 Department of Biomedical Sciences , Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Malaysia
3 Department of Human Anatomy , Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Malaysia
AuthorAffiliation_xml – name: 4 Department of Emergency Medicine , Faculty of Medicine , Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia
– name: 6 Department of Pharmaceutical Chemistry , Kulliyah of Pharmacy , International Islamic University Malaysia , Kuantan , Pahang , Malaysia
– name: 3 Department of Human Anatomy , Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Malaysia
– name: 1 Borneo Research on Algesia , Inflammation and Neurodegeneration (BRAIN) Group , Faculty of Medicine and Health Sciences , Sabah Universiti Malaysia , Kota Kinabalu , Sabah , Malaysia
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– name: 2 Department of Biomedical Sciences , Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Malaysia
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Keywords cataract
antioxidants
diabetes
purple sweet potato
retinal changes
plant
Language English
License Copyright © 2023 Hisamuddin, Naomi, Manan, Bahari, Othman, Embong, Ismail, Ahmed, Jumidil, Hussain and Zakaria.
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Edited by: Subhash C. Mandal, Government of West Bengal, India
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Snippet The objective of this study is to access the effect of purple sweet potato leaf (PSPL) extract on diabetic retinopathy (DR) of streptozotocin (STZ)-induced...
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SubjectTerms antioxidants
cataract
diabetes
Pharmacology
plant
purple sweet potato
retinal changes
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Title The role of lutein-rich purple sweet potato leaf extract on the amelioration of diabetic retinopathy in streptozotocin-induced Sprague-Dawley rats
URI https://www.ncbi.nlm.nih.gov/pubmed/37274105
https://search.proquest.com/docview/2822705802
https://pubmed.ncbi.nlm.nih.gov/PMC10232805
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Volume 14
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