Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation

Silent information regulator 1 ( SIRT1 ) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancr...

Full description

Saved in:

Bibliographic Details
Published in	Inflammation Vol. 43; no. 5; pp. 1589 - 1598
Main Authors	Singh, Vivek, Ubaid, Saba
Format	Journal Article
Language	English
Published	New York Springer US 01.10.2020 Springer Nature B.V
Subjects	Biomedical and Life Sciences Biomedicine Deacetylation Diabetes mellitus Fatty liver Forkhead protein Gene deletion Gene expression Histones Homeobox Immunology Inflammation Interleukin 1 Internal Medicine Liver diseases NAD Neurodegenerative diseases NF-κB protein Oxidative stress Pancreas Pathology Pharmacology/Toxicology Reactive oxygen species Review Rheumatology SIRT1 protein Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors brain inflammation liver SIRT1 pancreas oxidative stress
Online Access	Get full text

Cover

Loading…

Abstract	Silent information regulator 1 ( SIRT1 ) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as nuclear factor E2 related factor ( Nrf2 ), nuclear factor E2 related factor 2 ( Nef2 ), nuclear factor kappa B ( NF-kB ), pancreatic and duodenal homeobox factor 1 ( PDX1 ), interleukin-1 ( IL1 ), forkhead box class O ( FOXO ), and tumour necrosis factor alpha ( TNF-α ). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain. Graphical Abstract Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver
AbstractList	AbstractSilent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as nuclear factor E2 related factor (Nrf2), nuclear factor E2 related factor 2 (Nef2), nuclear factor kappa B (NF-kB), pancreatic and duodenal homeobox factor 1 (PDX1), interleukin-1 (IL1), forkhead box class O (FOXO), and tumour necrosis factor alpha (TNF-α). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain. Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as nuclear factor E2 related factor (Nrf2), nuclear factor E2 related factor 2 (Nef2), nuclear factor kappa B (NF-kB), pancreatic and duodenal homeobox factor 1 (PDX1), interleukin-1 (IL1), forkhead box class O (FOXO), and tumour necrosis factor alpha (TNF-α). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain. Graphical Abstract Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver. Silent information regulator 1 ( SIRT1 ) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as nuclear factor E2 related factor ( Nrf2 ), nuclear factor E2 related factor 2 ( Nef2 ), nuclear factor kappa B ( NF-kB ), pancreatic and duodenal homeobox factor 1 ( PDX1 ), interleukin-1 ( IL1 ), forkhead box class O ( FOXO ), and tumour necrosis factor alpha ( TNF-α ). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain. Graphical Abstract Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as nuclear factor E2 related factor (Nrf2), nuclear factor E2 related factor 2 (Nef2), nuclear factor kappa B (NF-kB), pancreatic and duodenal homeobox factor 1 (PDX1), interleukin-1 (IL1), forkhead box class O (FOXO), and tumour necrosis factor alpha (TNF-α). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain. Graphical Abstract Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver.Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as nuclear factor E2 related factor (Nrf2), nuclear factor E2 related factor 2 (Nef2), nuclear factor kappa B (NF-kB), pancreatic and duodenal homeobox factor 1 (PDX1), interleukin-1 (IL1), forkhead box class O (FOXO), and tumour necrosis factor alpha (TNF-α). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain. Graphical Abstract Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver.
Author	Ubaid, Saba Singh, Vivek
Author_xml	– sequence: 1 givenname: Vivek surname: Singh fullname: Singh, Vivek organization: Department of Biochemistry, King George’s Medical University (KGMU) – sequence: 2 givenname: Saba orcidid: 0000-0002-8925-5039 surname: Ubaid fullname: Ubaid, Saba email: Sabaubaid0@gmail.com, sabaubaid@kgmcindia.edu organization: Department of Biochemistry, King George’s Medical University (KGMU)
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32410071$$D View this record in MEDLINE/PubMed
BookMark	eNp9kU9LHDEYh4NY6qr9Ah5KwIs9TPvm32RyFKl2QRB27dWQzWSWyExikxlpv32zjrbgYckhITzPj5f3d4wOQwwOoTMCXwmA_JYJSMEqoFABoZxW6gAtiJCsokLWh2gBrIaKKSWP0HHOjwDQqIZ9REeM8l0CWaCHVewdjh1e-96FES9DF9NgRh8DXrnt1JsxJkzwxXq5uidfsP_37cMW3_32bXk9O7wek8sZm9DuInozzBmn6ENn-uw-vd4n6Of19_urH9Xt3c3y6vK2srxWY0U2TG7qhtnOth2hRjHTiq7j4AyDRioD3LYbcMIayVvrZCGdqq2qGZNKGXaCLubcpxR_TS6PevDZur43wcUpa8qhHMqlLOj5O_QxTimU6TQVohZcAIG9FOcgOGlEXajPr9S0GVyrn5IfTPqj3_ZbgGYGbIo5J9dp68eXzYzJ-F4T0DtQz1XqUqV-qVKrotJ36lv6XonNUi5w2Lr0f-w91l90c64F
CitedBy_id	crossref_primary_10_3390_ijms242216210 crossref_primary_10_1016_j_ijbiomac_2023_124581 crossref_primary_10_1016_j_jep_2024_117813 crossref_primary_10_1016_j_brainres_2022_148109 crossref_primary_10_2147_DDDT_S439873 crossref_primary_10_1016_j_bbr_2023_114738 crossref_primary_10_3390_cancers15123182 crossref_primary_10_1007_s11626_023_00808_9 crossref_primary_10_1016_j_ecoenv_2025_117969 crossref_primary_10_1007_s11010_022_04536_8 crossref_primary_10_3389_fphar_2024_1419390 crossref_primary_10_3389_fimmu_2024_1330677 crossref_primary_10_3390_nu15163578 crossref_primary_10_3390_biom14010030 crossref_primary_10_1002_ptr_8301 crossref_primary_10_3390_nu15245081 crossref_primary_10_1155_2024_7747599 crossref_primary_10_31146_1682_8658_ecg_199_3_5_14 crossref_primary_10_7762_cnr_2020_9_4_284 crossref_primary_10_2174_1567205020666221226140721 crossref_primary_10_1016_j_neulet_2021_135882 crossref_primary_10_1016_j_neuroscience_2022_09_021 crossref_primary_10_3389_fonc_2021_682762 crossref_primary_10_3390_nu14183789 crossref_primary_10_4110_in_2022_22_e21 crossref_primary_10_1016_j_arr_2022_101836 crossref_primary_10_1016_j_fsi_2024_109913 crossref_primary_10_1021_acs_jafc_3c05341 crossref_primary_10_1007_s11255_024_04162_x crossref_primary_10_1186_s13071_022_05406_4 crossref_primary_10_1016_j_jad_2022_04_063 crossref_primary_10_3724_abbs_2024124 crossref_primary_10_1186_s12951_022_01495_6 crossref_primary_10_1155_2023_5803323 crossref_primary_10_1096_fj_202400550R crossref_primary_10_1016_j_freeradbiomed_2023_06_024 crossref_primary_10_1038_s41434_023_00436_8 crossref_primary_10_1007_s11033_024_09296_w crossref_primary_10_1016_j_jss_2024_10_006 crossref_primary_10_3390_antiox12111925 crossref_primary_10_3390_ijms231911611 crossref_primary_10_1007_s10753_022_01685_2 crossref_primary_10_3390_cancers14235812 crossref_primary_10_1016_j_bcp_2023_115954 crossref_primary_10_1016_j_jtcme_2024_07_005 crossref_primary_10_1007_s00210_024_03319_w crossref_primary_10_1620_tjem_2024_J083 crossref_primary_10_18632_aging_205121 crossref_primary_10_1515_revneuro_2021_0118 crossref_primary_10_3390_biomedicines10102351 crossref_primary_10_1016_j_biopha_2023_114230 crossref_primary_10_1155_2022_1949718 crossref_primary_10_1080_01480545_2022_2104867 crossref_primary_10_1186_s12974_021_02250_8 crossref_primary_10_1016_j_intimp_2024_113026 crossref_primary_10_1016_j_taap_2022_116173 crossref_primary_10_1177_15459683231183716 crossref_primary_10_18632_aging_205015 crossref_primary_10_3389_fimmu_2024_1465849 crossref_primary_10_1002_prp2_70077 crossref_primary_10_1016_j_lfs_2021_119119 crossref_primary_10_3389_fimmu_2022_955175 crossref_primary_10_1007_s43032_024_01473_3 crossref_primary_10_3390_antiox14010038 crossref_primary_10_3390_ijms222312614 crossref_primary_10_1007_s10753_024_02041_2 crossref_primary_10_1186_s12933_025_02586_y crossref_primary_10_1007_s10787_024_01517_9 crossref_primary_10_1016_j_freeradbiomed_2024_04_238 crossref_primary_10_1016_j_tranon_2023_101656 crossref_primary_10_3389_fmolb_2023_1242935 crossref_primary_10_1007_s10863_022_09953_4 crossref_primary_10_3892_mmr_2024_13347 crossref_primary_10_1111_fcp_12926 crossref_primary_10_1007_s11064_025_04353_7 crossref_primary_10_1016_j_phyplu_2022_100390 crossref_primary_10_1155_2021_6657673 crossref_primary_10_1016_j_freeradbiomed_2023_06_013 crossref_primary_10_1016_j_knee_2024_03_002 crossref_primary_10_7717_peerj_15269 crossref_primary_10_1016_j_acthis_2022_151989 crossref_primary_10_1016_j_biopha_2023_116110 crossref_primary_10_2174_0118715303271634240319054728 crossref_primary_10_1007_s11010_024_05111_z crossref_primary_10_3390_ijms222413384 crossref_primary_10_1039_D2FO02877H crossref_primary_10_3390_cimb46090589 crossref_primary_10_1016_j_intimp_2025_114475 crossref_primary_10_1016_j_phymed_2024_156099 crossref_primary_10_1080_08941939_2022_2157521 crossref_primary_10_1002_ptr_8057 crossref_primary_10_1186_s12964_024_01903_4 crossref_primary_10_3390_ijms23148042 crossref_primary_10_1016_j_bbr_2024_115242 crossref_primary_10_1080_21655979_2021_1976503 crossref_primary_10_1007_s00109_024_02465_1 crossref_primary_10_1007_s40203_024_00211_6 crossref_primary_10_1177_1535370220975106 crossref_primary_10_3389_fcvm_2024_1385223 crossref_primary_10_4103_1735_5362_327511 crossref_primary_10_3389_fimmu_2022_943321 crossref_primary_10_1016_j_phymed_2023_154945 crossref_primary_10_1016_j_cyto_2025_156881 crossref_primary_10_1016_j_jep_2023_116622 crossref_primary_10_1016_j_exer_2023_109464 crossref_primary_10_3748_wjg_v30_i20_2709 crossref_primary_10_1186_s12944_021_01510_z crossref_primary_10_1186_s12967_024_04877_6 crossref_primary_10_3389_fnut_2022_989067 crossref_primary_10_1016_j_theriogenology_2024_11_021 crossref_primary_10_1021_acs_jafc_1c07761 crossref_primary_10_2174_0115680266299148240329062647 crossref_primary_10_1093_rb_rbac012 crossref_primary_10_3168_jds_2024_24936 crossref_primary_10_3389_fendo_2023_1172481 crossref_primary_10_1016_j_clim_2021_108879 crossref_primary_10_1186_s12872_022_02908_y crossref_primary_10_3390_ijms22157772 crossref_primary_10_1002_JLB_3HI0721_368R crossref_primary_10_1002_biof_1934 crossref_primary_10_3390_ijms26020812 crossref_primary_10_1016_j_ejphar_2024_177194 crossref_primary_10_3390_plants11182441 crossref_primary_10_1016_j_freeradbiomed_2022_09_001 crossref_primary_10_1111_jpi_12869 crossref_primary_10_1002_tox_23878 crossref_primary_10_1002_tox_23755 crossref_primary_10_1039_D4FO01900H crossref_primary_10_1007_s10495_022_01791_4 crossref_primary_10_1002_ptr_7984 crossref_primary_10_1016_j_bcp_2023_115643 crossref_primary_10_1080_1061186X_2024_2422882 crossref_primary_10_1590_acb380823 crossref_primary_10_1016_j_intimp_2022_109203 crossref_primary_10_3390_antiox13020163 crossref_primary_10_3390_biom13081210 crossref_primary_10_1167_iovs_64_3_16 crossref_primary_10_1016_j_neulet_2023_137418 crossref_primary_10_3390_molecules27196535 crossref_primary_10_3390_jcm9082623 crossref_primary_10_1186_s13020_024_00886_1 crossref_primary_10_1016_j_ecoenv_2023_115028 crossref_primary_10_3390_brainsci13040674 crossref_primary_10_1016_j_intimp_2024_112002 crossref_primary_10_1155_2022_7824436 crossref_primary_10_3390_ph16040533 crossref_primary_10_3389_fendo_2022_927223 crossref_primary_10_1016_j_jep_2024_119030 crossref_primary_10_18632_aging_103643 crossref_primary_10_1016_j_freeradbiomed_2022_05_006 crossref_primary_10_3390_cells13231945 crossref_primary_10_3390_antiox10091422 crossref_primary_10_4097_kja_23207 crossref_primary_10_1016_j_expneurol_2023_114658 crossref_primary_10_3390_molecules28041861 crossref_primary_10_1016_j_intimp_2021_108022 crossref_primary_10_1038_s41598_022_17972_9 crossref_primary_10_1038_s41514_024_00165_1 crossref_primary_10_3390_ijms241612854 crossref_primary_10_3389_fnmol_2022_984292 crossref_primary_10_3389_fimmu_2022_861290 crossref_primary_10_3389_fnut_2022_864358 crossref_primary_10_1016_j_tice_2024_102698 crossref_primary_10_1186_s12958_022_00991_6 crossref_primary_10_3171_2022_4_JNS212945 crossref_primary_10_3389_fnut_2022_924036 crossref_primary_10_1002_jcsm_13213 crossref_primary_10_1016_j_jcmgh_2024_05_002 crossref_primary_10_1186_s12868_025_00937_9 crossref_primary_10_2147_JIR_S372543 crossref_primary_10_1038_s41401_024_01341_5 crossref_primary_10_3389_fphar_2024_1426767 crossref_primary_10_1039_D2FO03122A crossref_primary_10_1055_a_2107_4015 crossref_primary_10_1134_S0026893324060074 crossref_primary_10_1002_gch2_202400178 crossref_primary_10_1007_s43440_024_00672_8 crossref_primary_10_1016_j_molstruc_2021_131788 crossref_primary_10_1016_j_phymed_2024_156288 crossref_primary_10_14814_phy2_70149 crossref_primary_10_1007_s00441_024_03860_3 crossref_primary_10_1016_j_jff_2024_106070 crossref_primary_10_1007_s11011_022_00956_z crossref_primary_10_1016_j_envpol_2021_117029 crossref_primary_10_1155_2022_7140961 crossref_primary_10_1186_s10020_024_00915_7 crossref_primary_10_1016_j_ijbiomac_2024_134809 crossref_primary_10_1016_j_neuroscience_2023_05_023 crossref_primary_10_1186_s13020_024_01002_z crossref_primary_10_1007_s00424_024_02974_5 crossref_primary_10_1007_s10695_022_01095_z crossref_primary_10_1007_s00210_024_02956_5 crossref_primary_10_3390_cancers15082378 crossref_primary_10_3389_fimmu_2022_831168 crossref_primary_10_1016_j_jep_2023_117481 crossref_primary_10_3390_nu13114155 crossref_primary_10_1016_j_jep_2024_119169 crossref_primary_10_1080_10799893_2021_1905665 crossref_primary_10_3892_br_2025_1924 crossref_primary_10_1007_s00109_023_02364_x crossref_primary_10_1186_s12967_023_04071_0 crossref_primary_10_2147_IJN_S377317 crossref_primary_10_3390_nu15010224 crossref_primary_10_1016_j_ejphar_2023_175520 crossref_primary_10_1038_s41598_023_44928_4 crossref_primary_10_3390_antiox12040800 crossref_primary_10_3390_jcm11133614 crossref_primary_10_1007_s12291_024_01203_1 crossref_primary_10_3389_fimmu_2021_795626 crossref_primary_10_3389_fcvm_2022_951597 crossref_primary_10_1002_jcsm_13553 crossref_primary_10_1007_s12035_024_04634_2 crossref_primary_10_1016_j_jgr_2023_11_006 crossref_primary_10_1016_j_jep_2024_118823 crossref_primary_10_3389_fphar_2021_751028 crossref_primary_10_1186_s12951_022_01651_y crossref_primary_10_3390_jcdd11120408 crossref_primary_10_3390_biomedicines12040855 crossref_primary_10_1152_ajprenal_00297_2024 crossref_primary_10_3390_brainsci13050719 crossref_primary_10_1016_j_biopha_2024_116917 crossref_primary_10_3389_fcell_2023_1309719 crossref_primary_10_3389_fphar_2022_907835 crossref_primary_10_1002_ptr_8221 crossref_primary_10_3390_foods14010071 crossref_primary_10_3390_gels10050333 crossref_primary_10_1007_s40200_024_01525_0 crossref_primary_10_3389_fimmu_2022_911381 crossref_primary_10_1167_iovs_63_10_19 crossref_primary_10_1093_gerona_glac175 crossref_primary_10_1007_s11064_025_04335_9 crossref_primary_10_7759_cureus_28774 crossref_primary_10_3892_etm_2024_12619 crossref_primary_10_3389_fimmu_2023_1177140 crossref_primary_10_1038_s42003_024_07234_x crossref_primary_10_3389_fimmu_2021_779177 crossref_primary_10_5713_ab_23_0202 crossref_primary_10_3389_fnmol_2024_1394932 crossref_primary_10_1016_j_neuroscience_2024_01_017 crossref_primary_10_1113_JP285362 crossref_primary_10_1080_10286020_2021_1949302 crossref_primary_10_1111_cns_14692 crossref_primary_10_3389_fcvm_2023_1174816 crossref_primary_10_26599_FMH_2026_9420093 crossref_primary_10_3390_ph17111495 crossref_primary_10_1016_j_molstruc_2021_131069 crossref_primary_10_3389_fcvm_2021_701583 crossref_primary_10_3390_ijms252111652 crossref_primary_10_1038_s41598_024_52120_5 crossref_primary_10_4062_biomolther_2024_188 crossref_primary_10_1007_s10787_022_01117_5 crossref_primary_10_1007_s12035_024_04534_5 crossref_primary_10_1523_JNEUROSCI_1886_23_2024 crossref_primary_10_3390_ijms242417298 crossref_primary_10_1039_D4FO01354A crossref_primary_10_2147_JIR_S476288 crossref_primary_10_1007_s11064_023_03880_5 crossref_primary_10_3389_fphar_2023_1213506 crossref_primary_10_23736_S0026_4806_22_07879_X crossref_primary_10_1016_j_ecoenv_2024_117385 crossref_primary_10_1016_j_heliyon_2024_e36921 crossref_primary_10_3390_biom12060830 crossref_primary_10_2174_0113816128305609240529114411 crossref_primary_10_1080_07853890_2023_2284366 crossref_primary_10_1016_j_brainresbull_2025_111272 crossref_primary_10_1016_j_phrs_2024_107155 crossref_primary_10_1016_j_phymed_2025_156538 crossref_primary_10_1016_j_heliyon_2024_e36494 crossref_primary_10_1016_j_fct_2025_115373 crossref_primary_10_1016_j_htct_2024_02_016 crossref_primary_10_1016_j_biopha_2024_117208 crossref_primary_10_1038_s41598_024_59836_4 crossref_primary_10_3390_ijms232315140 crossref_primary_10_1007_s10517_022_05439_w crossref_primary_10_1016_j_tiv_2023_105722 crossref_primary_10_1093_procel_pwad048 crossref_primary_10_1016_j_archger_2023_105255 crossref_primary_10_1016_j_jogoh_2022_102516 crossref_primary_10_1155_2022_1148874 crossref_primary_10_1016_j_tice_2024_102637 crossref_primary_10_1080_14728222_2024_2367640 crossref_primary_10_1016_j_ymthe_2024_01_037 crossref_primary_10_1002_jbt_70150 crossref_primary_10_3389_fnmol_2022_920216
Cites_doi	10.3748/wjg.v20.i36.13079 10.1001/jama.286.3.327 10.1038/sj.emboj.7600244 10.7150/ijbs.6.682 10.1371/journal.pone.0120849 10.1016/j.jns.2014.05.003 10.1016/j.jmb.2013.10.009 10.1038/s41598-018-35687-8 10.1053/j.gastro.2013.11.008 10.7150/ijbs.7529 10.1371/journal.pone.0001376 10.1128/MCB.00657-10 10.2337/db06-1650 10.1016/j.cell.2012.01.032 10.1101/gad.265462.115 10.3410/M3-7 10.1016/j.molcel.2011.07.038 10.1523/JNEUROSCI.2939-14.2015 10.1016/j.neulet.2013.08.020 10.1016/j.jmb.2004.02.006 10.1038/srep38186 10.1101/gad.12.12.1763 10.2337/diabetes.52.3.812 10.1016/0016-5085(95)90724-6 10.1074/jbc.M117.813980 10.3389/fnmol.2017.00443 10.1016/j.neurobiolaging.2007.04.013 10.1074/jbc.M202066200 10.1016/j.jep.2012.09.044 10.1093/emboj/21.10.2383 10.1016/j.bbadis.2012.08.009 10.2337/diabetes.48.3.507 10.1111/j.1368-5031.2006.00825.x 10.1038/371606a0 10.1074/jbc.M609554200 10.1073/pnas.0802917105 10.1055/s-2005-858252 10.1111/j.1755-5922.2010.00218.x 10.1038/onc.2011.35 10.1038/s41467-016-0009-6 10.1038/nature08197 10.1210/en.2009-1013 10.1002/mds.20527 10.1016/j.nbd.2006.06.013 10.1038/s41598-016-0028-x 10.1128/MCB.00705-08 10.1016/j.freeradbiomed.2003.11.023 10.1371/journal.pone.0059122 10.1002/mds.21803 10.1016/S0092-8674(00)80595-4 10.1038/srep16013 10.1002/mnfr.201500144 10.1007/BF01255596 10.7326/0003-4819-126-2-199701150-00008 10.1080/10408398.2010.529624 10.1172/JCI11830 10.1016/j.freeradbiomed.2009.06.030 10.2174/1389557516666160620095103 10.1016/j.bbrc.2015.10.094 10.1016/j.toxlet.2016.12.010 10.1016/j.jgr.2018.02.002 10.1002/biof.1032 10.1016/j.cmet.2012.04.003 10.1517/13543770902762893 10.1371/journal.pone.0134391 10.1016/S0168-8278(02)00099-5 10.2337/diabetes.52.12.2896 10.1038/nature06261 10.1002/hep.510290347 10.1152/ajpendo.00417.2009 10.1016/j.expneurol.2007.07.004 10.1016/j.tox.2018.08.010 10.1016/j.freeradbiomed.2011.06.017 10.1016/j.bmcl.2018.01.021 10.1126/science.1231097 10.1016/j.cell.2009.01.038 10.1038/ng1097-138 10.2337/dc08-1161 10.1016/j.bbadis.2015.01.012 10.2337/db13-0863 10.1038/srep00070 10.3390/ijms17091575 10.1007/s00018-016-2161-x 10.1016/j.biopha.2018.05.003 10.1007/s12272-013-0223-2 10.1152/ajpgi.00016.2009
ContentType	Journal Article
Copyright	Springer Science+Business Media, LLC, part of Springer Nature 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020.
Copyright_xml	– notice: Springer Science+Business Media, LLC, part of Springer Nature 2020 – notice: Springer Science+Business Media, LLC, part of Springer Nature 2020.
DBID	AAYXX CITATION NPM 3V. 7T5 7TO 7U9 7X7 7XB 88E 8AO 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8
DOI	10.1007/s10753-020-01242-9
DatabaseName	CrossRef PubMed ProQuest Central (Corporate) Immunology Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic
DatabaseTitle	CrossRef PubMed Oncogenes and Growth Factors Abstracts ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Oncogenes and Growth Factors Abstracts Oncogenes and Growth Factors Abstracts PubMed MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1573-2576
EndPage	1598
ExternalDocumentID	32410071 10_1007_s10753_020_01242_9
Genre	Journal Article Review
GrantInformation_xml	– fundername: DBT grantid: No. BT/IN/Indo-US/Foldscope/39/2015 – fundername: Indian Council of Medical Research grantid: 3/1/2/76/Neuro/2018-NCD-I funderid: http://dx.doi.org/10.13039/501100001411 – fundername: Indian Council of Medical Research grantid: 3/1/2/76/Neuro/2018-NCD-I
GroupedDBID	--- -53 -5E -5G -BR -EM -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 1N0 1SB 2.D 203 28- 29I 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AAJSJ AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACUDM ACULB ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFFNX AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BSONS BVXVI C6C CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GXS H13 HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LLZTM M1P M4Y MA- N2Q NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S37 S3B SAP SBY SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 Y6R YLTOR Z45 Z7U Z83 Z87 Z8O Z8W Z91 ZGI ZMTXR ZOVNA ~A9 ~EX AAPKM AAYXX ABBRH ABDBE ABEEZ ABFSG ACSTC ADHKG AEZWR AFDZB AFGXO AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT NPM 7T5 7TO 7U9 7XB 8FK H94 K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS 7X8
ID	FETCH-LOGICAL-c469t-1b37b683cfcdf12a93ad5ff40ea30879a04cdb0e5ca74dce73cfe96c9633799a3
IEDL.DBID	7X7
ISSN	0360-3997 1573-2576
IngestDate	Tue Aug 05 10:58:45 EDT 2025 Fri Jul 25 21:11:44 EDT 2025 Fri Jul 25 21:11:34 EDT 2025 Wed Feb 19 02:27:52 EST 2025 Tue Jul 01 01:49:25 EDT 2025 Thu Apr 24 22:53:11 EDT 2025 Fri Feb 21 02:48:12 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	5
Keywords	brain inflammation liver SIRT1 pancreas oxidative stress
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c469t-1b37b683cfcdf12a93ad5ff40ea30879a04cdb0e5ca74dce73cfe96c9633799a3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ORCID	0000-0002-8925-5039
PMID	32410071
PQID	2440541856
PQPubID	37566
PageCount	10
ParticipantIDs	proquest_miscellaneous_2404042477 proquest_journals_2556545010 proquest_journals_2440541856 pubmed_primary_32410071 crossref_citationtrail_10_1007_s10753_020_01242_9 crossref_primary_10_1007_s10753_020_01242_9 springer_journals_10_1007_s10753_020_01242_9
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2020-10-01
PublicationDateYYYYMMDD	2020-10-01
PublicationDate_xml	– month: 10 year: 2020 text: 2020-10-01 day: 01
PublicationDecade	2020
PublicationPlace	New York
PublicationPlace_xml	– name: New York – name: United States
PublicationTitle	Inflammation
PublicationTitleAbbrev	Inflammation
PublicationTitleAlternate	Inflammation
PublicationYear	2020
Publisher	Springer US Springer Nature B.V
Publisher_xml	– name: Springer US – name: Springer Nature B.V
References	Reijnders, Ehrt, Weber, Aarsland, Leentjens (CR53) 2008; 23 Sheth, Gordon, Chopra (CR12) 1997; 126 Price, Gomes, Ling, Duarte, Martin-Montalvo, North, Agarwal, Ye, Ramadori, Teodoro, Hubbard (CR4) 2012; 15 Tak, Firestein (CR18) 2001; 107 Hou, Rooklin, Fang, Zhang (CR68) 2016; 6 CR39 Herder, Brunner, Rathmann, Strassburger, Tabak, Schloot, Witte (CR43) 2009; 32 Wang, Liang, Chen, Zhao (CR76) 2016; 2016 Yoshizaki, Milne, Imamura, Schenk, Sonoda, Babendure, Lu, Smith, Jirousek, Olefsky (CR47) 2009; 29 Bhullar, Hubbard (CR82) 2015; 1852 Leal, Casabona, Puntel, PITOSSI (CR60) 2013; 7 Caldwell, Oelsner, Iezzoni, Hespenheide, Battle, Driscoll (CR9) 1999; 29 Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg (CR57) 1999; 96 Liu, Baker, Bhatia, Zhu, Baker (CR16) 2016; 73 Tang, Jiang, Ponnusamy, Diallo (CR25) 2014; 20 Jonsson, Carlsson, Edlund, Edlund (CR32) 1994; 371 Caligiuri, Gentilini, Marra (CR17) 2016; 17 Renault, Thekkat, Hoang, White, Brady, Broz, Venturelli, Johnson, Oskoui, Xuan, Santo (CR55) 2011; 30 Spranger, Kroke, Möhlig, Hoffmann, Bergmann, Ristow, Boeing, Pfeiffer (CR41) 2003; 52 Wang, Li, Deng (CR29) 2010; 6 Wu, Zhou, Lu, Zhang, Jian, Liu, Li, Li, Wang, Li (CR37) 2012; 1822 Ferrari, Godoy, Tarelli, Chertoff, Depino, Pitossi (CR63) 2006; 24 Yang, Lai, Ouyang, Yang (CR84) 2018; 409 Langley, Pearson, Faretta, Bauer, Frye, Minucci, Pelicci, Kouzarides (CR56) 2002; 21 Wang, Xu, Kim, Xiao, Deng (CR36) 2013; 9 Deng, Xu, Zhang, Li, Gan, Li (CR3) 2013; 53 Sharma, Zangen, Reitz, Taneja, Lissauer, Miller, Weir, Habener, Bonner-Weir (CR33) 1999; 48 Kim, Kim, Son, Moon, Pyo, Um (CR74) 2015; 467 Zhang, Li, Chen, Li, Ma, Jia, Wang, Bao, Liang, Chen, Li (CR75) 2017; 7 Tanno, Sakamoto, Miura, Shimamoto, Horio (CR5) 2007; 282 Huang, Kwan, Leung, Yao, Wang, Dong, Tsim (CR85) 2019; 43 Propst, Propst, Judmaier, Vogel (CR11) 1995; 108 Westwell-Roper, Ehses, Verchere (CR46) 2014; 63 Hubbard, Gomes, Dai, Li, Case, Considine, Riera, Lee, Lamming, Pentelute, Schuman (CR67) 2013; 339 Kim, Park, Park, Choi, Park, Chung, Kim, Lee, Chung (CR86) 2014; 37 Schug, Xu, Gao, Peres-da-Silva, Draper, Fessler, Purushotham, Li (CR23) 2010; 30 CR89 Ye, Liu, Wei, Lu, Huang, Luo, Xie (CR64) 2013; 553 Ahlgren, Jonsson, Jonsson, Simu, Edlund (CR34) 1998; 12 Youdim, Qaiser, Begley, Rice-Evans, Abbott (CR80) 2004; 36 Zhou, Wang, Li, Yu, Zhao (CR81) 2018; 10 Villalba, Alcaín (CR77) 2012; 38 Xu, Gao, Zhang, Rivera, Yin, Weng, Ye (CR22) 2010; 151 Yoshizaki, Schenk, Imamura, Babendure, Sonoda, Bae, Oh, Lu, Milne, Westphal, Bandyopadhyay (CR48) 2010; 298 Zhang, Hu, Ding, Zeng, Shan, Fan, Zhao, Shi, Gao, Xu, Wang (CR83) 2017; 267 Mulero, Huang, Nguyen, Wang, Li, Biswas, Ghosh (CR19) 2017; 292 Qiu, Luo, Chen (CR72) 2018; 103 Kang, Suh, Jung, Jung, Kim, Chung (CR6) 2011; 44 Konitsiotis, Bostantjopoulou, Chondrogiorgi, Katsarou, Tagaris, Mavromatis, Ntzani, Mentenopoulos (CR50) 2014; 343 Zeng, Shan, Gao, Gao, Hu, Wang, Zhang, Li, Tian, Xu, Peng (CR70) 2015; 5 Cao, Wang, Qiu, Liu, Jiang, Yang, Xu (CR66) 2015; 29 Pfluger, Herranz, Velasco-Miguel, Serrano, Tschöp (CR24) 2008; 105 Modi, Yaluri, Kokkola, Laakso (CR69) 2017; 7 Minor, Baur, Gomes, Ward, Csiszar, Mercken, Abdelmohsen, Shin, Canto, Scheibye-Knudsen, Krawczyk (CR87) 2011; 1 Pradhan, Manson, Rifai, Buring, Ridker (CR44) 2001; 286 CR15 Kaneto, Xu, Fujii, Kim, Bonner-Weir, Weir (CR38) 2002; 277 Ishisaka, Ichikawa, Sakakibara, Piskula, Nakamura, Kato, Ito, Miyamoto, Tsuji, Kawai, Terao (CR79) 2011; 51 CR13 Ehses, Perren, Eppler, Ribaux, Pospisilik, Maor-Cahn, Gueripel, Ellingsgaard, Schneider, Biollaz, Fontana (CR45) 2007; 56 Han, Gu, Shan, Mi, Sun, Shi, Zhang, Lu, Han, Gong, Yu (CR8) 2017; 8 Cho, Chen, Sayed, Ward, Gao, Nguyen, Krabbe, Sohn, Lo, Minami, Devidze (CR58) 2015; 35 Bai, Yao, Ma, Xu (CR71) 2018; 18 Alcaín, Villalba (CR78) 2009; 19 Ding, Tian, He, Jiang, Wang, Wan (CR14) 2012; 144 Yin, Hu, Liang, Ajmo, Li, Bataller, Odena, Stevens, You (CR28) 2014; 146 CR51 Shen, Ajmo, Rogers, Liang, Le, Murr, Peng, You (CR21) 2009; 296 Finkel, Deng, Mostoslavsky (CR2) 2009; 460 Shimada, Hashimoto, Taniai, Hasegawa, Okuda, Hayashi, Takasaki, Ludwig (CR10) 2002; 37 Campagna, Spilman, Jagodzinska, Bai, Hatami, Zhu, Bilousova, Jun, Elias, Pham, Cole (CR90) 2018; 8 Hung, Chan, Chu, Tsai (CR73) 2015; 59 Aarsland, Zaccai, Brayne (CR52) 2005; 20 Gautier, Corti, Brice (CR54) 2014; 170 Tansey, McCoy, Frank-Cannon (CR62) 2007; 208 Kim, An, Kim, Lee, Lee, Ullah, Kim, Jeong, Moon, Lee, Yang (CR92) 2018; 28 Staffers, Ferrer, Clarke, Habener (CR35) 1997; 17 Yao, Zhang, Zhen, He, Zhao, Li, Yang, Gao, Guo, Fu, Liu (CR93) 2018; 9 CR27 Kansanen, Kivelä, Levonen (CR26) 2009; 47 Milne, Lambert, Schenk, Carney, Smith, Gagne, Jin, Boss, Perni, Vu, Bemis (CR88) 2007; 450 Herder, Illig, Rathmann, Martin, Haastert, Müller-Scholze, Holle, Thorand, Koenig, Wichmann, Kolb (CR42) 2005; 67 Gregoretti, Lee, Goodson (CR1) 2004; 338 Wright, Scism-Bacon, Glass (CR30) 2006; 60 Pelvig, Pakkenberg, Stark, Pakkenberg (CR49) 2008; 29 Elmarakby, Sullivan (CR40) 2012; 30 CR61 Tennen, Michishita-Kioi, Chua (CR65) 2012; 148 Davenport, Huber, Hoelz (CR7) 2014; 426 Kawamori, Kajimoto, Kaneto, Umayahara, Fujitani, Miyatsuka, Watada, Leibiger, Yamasaki, Hori (CR31) 2003; 52 Saijo, Winner, Carson, Collier, Boyer, Rosenfeld, Gage, Glass (CR59) 2009; 137 Ögren, Holm, Hall, Lindberg (CR91) 1984; 59 Yeung, Hoberg, Ramsey, Keller, Jones, Frye, Mayo (CR20) 2004; 23 JM Villalba (1242_CR77) 2012; 38 NL Price (1242_CR4) 2012; 15 C Han (1242_CR8) 2017; 8 K Saijo (1242_CR59) 2009; 137 A Propst (1242_CR11) 1995; 108 Z Shen (1242_CR21) 2009; 296 N Zhang (1242_CR83) 2017; 267 U Ahlgren (1242_CR34) 1998; 12 Y Zhou (1242_CR81) 2018; 10 AD Pradhan (1242_CR44) 2001; 286 J Jonsson (1242_CR32) 1994; 371 Y Huang (1242_CR85) 2019; 43 W Liu (1242_CR16) 2016; 73 CY Westwell-Roper (1242_CR46) 2014; 63 E Langley (1242_CR56) 2002; 21 J Campagna (1242_CR90) 2018; 8 J Spranger (1242_CR41) 2003; 52 1242_CR89 D Aarsland (1242_CR52) 2005; 20 CA Gautier (1242_CR54) 2014; 170 FJ Alcaín (1242_CR78) 2009; 19 X Bai (1242_CR71) 2018; 18 ZQ Yao (1242_CR93) 2018; 9 A Brunet (1242_CR57) 1999; 96 JS Reijnders (1242_CR53) 2008; 23 A Ishisaka (1242_CR79) 2011; 51 T Finkel (1242_CR2) 2009; 460 H Kaneto (1242_CR38) 2002; 277 D Cao (1242_CR66) 2015; 29 RI Tennen (1242_CR65) 2012; 148 W Zeng (1242_CR70) 2015; 5 F Yeung (1242_CR20) 2004; 23 A Sharma (1242_CR33) 1999; 48 JA Ehses (1242_CR45) 2007; 56 L Wu (1242_CR37) 2012; 1822 1242_CR51 PT Pfluger (1242_CR24) 2008; 105 RB Ding (1242_CR14) 2012; 144 1242_CR13 1242_CR15 J Ye (1242_CR64) 2013; 553 CH Hung (1242_CR73) 2015; 59 SC Kim (1242_CR74) 2015; 467 X Hou (1242_CR68) 2016; 6 KS Bhullar (1242_CR82) 2015; 1852 AA Elmarakby (1242_CR40) 2012; 30 E Kansanen (1242_CR26) 2009; 47 TT Schug (1242_CR23) 2010; 30 SO Ögren (1242_CR91) 1984; 59 KA Youdim (1242_CR80) 2004; 36 M Tanno (1242_CR5) 2007; 282 MG Tansey (1242_CR62) 2007; 208 GF Deng (1242_CR3) 2013; 53 Y Wang (1242_CR76) 2016; 2016 DP Pelvig (1242_CR49) 2008; 29 1242_CR61 1242_CR27 MJ Kim (1242_CR92) 2018; 28 M Shimada (1242_CR10) 2002; 37 MC Mulero (1242_CR19) 2017; 292 I Gregoretti (1242_CR1) 2004; 338 RH Wang (1242_CR36) 2013; 9 CC Ferrari (1242_CR63) 2006; 24 T Yoshizaki (1242_CR47) 2009; 29 MC Leal (1242_CR60) 2013; 7 L Qiu (1242_CR72) 2018; 103 PP Tak (1242_CR18) 2001; 107 VM Renault (1242_CR55) 2011; 30 DA Staffers (1242_CR35) 1997; 17 A Caligiuri (1242_CR17) 2016; 17 S Modi (1242_CR69) 2017; 7 C Herder (1242_CR42) 2005; 67 SG Sheth (1242_CR12) 1997; 126 H Kang (1242_CR6) 2011; 44 D Kawamori (1242_CR31) 2003; 52 C Herder (1242_CR43) 2009; 32 RK Minor (1242_CR87) 2011; 1 AM Davenport (1242_CR7) 2014; 426 SH Caldwell (1242_CR9) 1999; 29 F Xu (1242_CR22) 2010; 151 RH Wang (1242_CR29) 2010; 6 1242_CR39 S Konitsiotis (1242_CR50) 2014; 343 T Yoshizaki (1242_CR48) 2010; 298 E Wright Jr (1242_CR30) 2006; 60 DH Kim (1242_CR86) 2014; 37 BP Hubbard (1242_CR67) 2013; 339 W Tang (1242_CR25) 2014; 20 QY Yang (1242_CR84) 2018; 409 C Zhang (1242_CR75) 2017; 7 JC Milne (1242_CR88) 2007; 450 SH Cho (1242_CR58) 2015; 35 H Yin (1242_CR28) 2014; 146 33829418 - Inflammation. 2021 Apr 8
References_xml	– volume: 59 start-page: 265 issue: 4 year: 1984 end-page: 288 ident: CR91 article-title: Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia publication-title: Journal of Neural Transmission – volume: 105 start-page: 9793 issue: 28 year: 2008 end-page: 9798 ident: CR24 article-title: Sirt1 protects against high-fat diet-induced metabolic damage publication-title: Proceedings of the National Academy of Sciences – volume: 6 start-page: 682 issue: 7 year: 2010 end-page: 690 ident: CR29 article-title: Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition publication-title: International Journal of Biological Sciences – volume: 7 start-page: 1 issue: 1 year: 2017 end-page: 2 ident: CR75 article-title: Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways publication-title: Scientific Reports – volume: 2016 start-page: 1 year: 2016 end-page: 9 ident: CR76 article-title: Screening SIRT1 activators from medicinal plants as bioactive compounds against oxidative damage in mitochondrial function publication-title: Oxidative Medicine and Cellular Longevity – volume: 37 start-page: 813 issue: 6 year: 2014 end-page: 820 ident: CR86 article-title: Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress publication-title: Archives of Pharmacal Research – volume: 29 start-page: 1363 issue: 5 year: 2009 end-page: 1374 ident: CR47 article-title: SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes publication-title: Molecular and Cellular Biology – volume: 9 start-page: 1 issue: 7 year: 2018 end-page: 4 ident: CR93 article-title: A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma publication-title: Cell Death & Disease – ident: CR39 – volume: 12 start-page: 1763 issue: 12 year: 1998 end-page: 1768 ident: CR34 article-title: β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes publication-title: Genes & Development – ident: CR51 – volume: 43 start-page: 517 issue: 4 year: 2019 end-page: 526 ident: CR85 article-title: Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: A functional comparison of different extraction solvents publication-title: Journal of Ginseng Research – volume: 37 start-page: 154 issue: 1 year: 2002 end-page: 160 ident: CR10 article-title: Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis publication-title: Journal of Hepatology – volume: 30 start-page: 49 issue: 1 year: 2012 end-page: 59 ident: CR40 article-title: Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy publication-title: Cardiovascular Therapeutics – volume: 63 start-page: 1698 issue: 5 year: 2014 end-page: 1711 ident: CR46 article-title: Resident macrophages mediate islet amyloid polypeptide–induced islet IL-1β production and β-cell dysfunction publication-title: Diabetes. – volume: 103 start-page: 1585 year: 2018 end-page: 1591 ident: CR72 article-title: Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats publication-title: Biomedicine & Pharmacotherapy – volume: 296 start-page: G1047 issue: 5 year: 2009 end-page: G1053 ident: CR21 article-title: Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines publication-title: American Journal of Physiology. Gastrointestinal and Liver Physiology – volume: 339 start-page: 1216 issue: 6124 year: 2013 end-page: 1219 ident: CR67 article-title: Evidence for a common mechanism of SIRT1 regulation by allosteric activators publication-title: Science. – volume: 47 start-page: 1310 issue: 9 year: 2009 end-page: 1317 ident: CR26 article-title: Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12, 14-prostaglandin J2 publication-title: Free Radical Biology & Medicine – ident: CR61 – volume: 282 start-page: 6823 issue: 9 year: 2007 end-page: 6832 ident: CR5 article-title: Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1 publication-title: The Journal of Biological Chemistry – volume: 208 start-page: 1 issue: 1 year: 2007 end-page: 25 ident: CR62 article-title: Neuroinflammatory mechanisms in Parkinson’s disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention publication-title: Experimental Neurology – volume: 56 start-page: 2356 issue: 9 year: 2007 end-page: 2370 ident: CR45 article-title: Increased number of islet-associated macrophages in type 2 diabetes publication-title: Diabetes. – volume: 44 start-page: 203 issue: 2 year: 2011 end-page: 213 ident: CR6 article-title: Peptide switch is essential for Sirt1 deacetylase activity publication-title: Molecular Cell – volume: 1852 start-page: 1209 issue: 6 year: 2015 end-page: 1218 ident: CR82 article-title: Lifespan and healthspan extension by resveratrol publication-title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease – volume: 108 start-page: 1607 issue: 5 year: 1995 ident: CR11 article-title: Prognosis in nonalcoholic steatohepatitis publication-title: Gastroenterology. – volume: 23 start-page: 2369 issue: 12 year: 2004 end-page: 2380 ident: CR20 article-title: Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase publication-title: The EMBO Journal – volume: 292 start-page: 18821 issue: 46 year: 2017 end-page: 18830 ident: CR19 article-title: DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor κB are not correlated publication-title: The Journal of Biological Chemistry – volume: 35 start-page: 807 issue: 2 year: 2015 end-page: 818 ident: CR58 article-title: SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β publication-title: The Journal of Neuroscience – volume: 8 start-page: 1 issue: 1 year: 2018 end-page: 5 ident: CR90 article-title: A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model publication-title: Scientific Reports – volume: 18 start-page: 1151 issue: 13 year: 2018 end-page: 1157 ident: CR71 article-title: Small molecules as SIRT modulators publication-title: Mini Reviews in Medicinal Chemistry – volume: 409 start-page: 144 year: 2018 end-page: 151 ident: CR84 article-title: Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats publication-title: Toxicology. – volume: 36 start-page: 592 issue: 5 year: 2004 end-page: 604 ident: CR80 article-title: Flavonoid permeability across an in situ model of the blood–brain barrier publication-title: Free Radical Biology & Medicine – ident: CR15 – volume: 30 start-page: 4712 issue: 19 year: 2010 end-page: 4721 ident: CR23 article-title: Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress publication-title: Molecular and Cellular Biology – volume: 67 start-page: 115 issue: S 01 year: 2005 end-page: 121 ident: CR42 article-title: Inflammation and type 2 diabetes: Results from KORA Augsburg publication-title: Das Gesundheitswesen – volume: 7 start-page: 53 year: 2013 ident: CR60 article-title: Interleukin-1β and tumor necrosis factor-α: Reliable targets for protective therapies in Parkinson’s disease? publication-title: Frontiers in Cellular Neuroscience – volume: 151 start-page: 2504 issue: 6 year: 2010 end-page: 2514 ident: CR22 article-title: Lack of SIRT1 (mammalian sirtuin 1) activity leads to liver steatosis in the SIRT1+/− mice: A role of lipid mobilization and inflammation publication-title: Endocrinology. – volume: 6 start-page: 38186 year: 2016 ident: CR68 article-title: Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation publication-title: Scientific Reports – volume: 96 start-page: 857 issue: 6 year: 1999 end-page: 868 ident: CR57 publication-title: cell – volume: 24 start-page: 183 issue: 1 year: 2006 end-page: 193 ident: CR63 article-title: Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra publication-title: Neurobiology of Disease – volume: 48 start-page: 507 issue: 3 year: 1999 end-page: 513 ident: CR33 article-title: The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration publication-title: Diabetes. – volume: 52 start-page: 812 issue: 3 year: 2003 end-page: 817 ident: CR41 article-title: Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study publication-title: Diabetes. – volume: 137 start-page: 47 issue: 1 year: 2009 end-page: 59 ident: CR59 article-title: A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death publication-title: Cell. – volume: 8 start-page: 1 issue: 1 year: 2017 end-page: 2 ident: CR8 article-title: O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress publication-title: Nature Communications – volume: 144 start-page: 457 issue: 3 year: 2012 end-page: 465 ident: CR14 article-title: Herbal medicines for the prevention of alcoholic liver disease: A review publication-title: Journal of Ethnopharmacology – volume: 371 start-page: 606 issue: 6498 year: 1994 end-page: 609 ident: CR32 article-title: Insulin-promoter-factor 1 is required for pancreas development in mice publication-title: Nature. – volume: 277 start-page: 30010 issue: 33 year: 2002 end-page: 30018 ident: CR38 article-title: Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression publication-title: The Journal of Biological Chemistry – volume: 52 start-page: 2896 issue: 12 year: 2003 end-page: 2904 ident: CR31 article-title: Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH2-terminal kinase publication-title: Diabetes. – volume: 29 start-page: 664 issue: 3 year: 1999 end-page: 669 ident: CR9 article-title: Cryptogenic cirrhosis: Clinical characterization and risk factors for underlying disease publication-title: Hepatology. – volume: 450 start-page: 712 issue: 7170 year: 2007 end-page: 716 ident: CR88 article-title: Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes publication-title: Nature. – ident: CR89 – volume: 53 start-page: 296 issue: 3 year: 2013 end-page: 306 ident: CR3 article-title: Phenolic compounds and bioactivities of pigmented rice publication-title: Critical Reviews in Food Science and Nutrition – volume: 17 start-page: 1575 issue: 9 year: 2016 ident: CR17 article-title: Molecular pathogenesis of NASH publication-title: International Journal of Molecular Sciences – volume: 19 start-page: 403 issue: 4 year: 2009 end-page: 414 ident: CR78 article-title: Sirtuin activators publication-title: Expert Opinion on Therapeutic Patents – volume: 10 start-page: 443 year: 2018 ident: CR81 article-title: SIRT1/PGC-1α signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats publication-title: Frontiers in Molecular Neuroscience – volume: 9 start-page: 934 issue: 9 year: 2013 end-page: 946 ident: CR36 article-title: SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation publication-title: International Journal of Biological Sciences – volume: 343 start-page: 36 issue: 1–2 year: 2014 end-page: 40 ident: CR50 article-title: Clinical characteristics of Parkinson’s disease patients in Greece: A multicenter, nation-wide, cross-sectional study publication-title: Journal of the Neurological Sciences – volume: 73 start-page: 1969 issue: 10 year: 2016 end-page: 1987 ident: CR16 article-title: Pathogenesis of nonalcoholic steatohepatitis publication-title: Cellular and Molecular Life Sciences – volume: 20 start-page: 13079 issue: 36 year: 2014 end-page: 13087 ident: CR25 article-title: Role of Nrf2 in chronic liver disease publication-title: World journal of gastroenterology: WJG – volume: 286 start-page: 327 issue: 3 year: 2001 end-page: 334 ident: CR44 article-title: C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus publication-title: Jama. – volume: 148 start-page: 387 issue: 3 year: 2012 end-page: 389 ident: CR65 article-title: Finding a target for resveratrol publication-title: Cell. – volume: 29 start-page: 1754 issue: 11 year: 2008 end-page: 1762 ident: CR49 article-title: Neocortical glial cell numbers in human brains publication-title: Neurobiology of Aging – volume: 38 start-page: 349 issue: 5 year: 2012 end-page: 359 ident: CR77 article-title: Sirtuin activators and inhibitors publication-title: Biofactors. – ident: CR27 – volume: 1822 start-page: 1815 issue: 11 year: 2012 end-page: 1825 ident: CR37 article-title: Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction publication-title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease – volume: 59 start-page: 1905 issue: 10 year: 2015 end-page: 1917 ident: CR73 article-title: Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation publication-title: Molecular Nutrition & Food Research – volume: 23 start-page: 183 issue: 2 year: 2008 end-page: 189 ident: CR53 article-title: A systematic review of prevalence studies of depression in Parkinson’s disease publication-title: Movement Disorders – volume: 51 start-page: 1329 issue: 7 year: 2011 end-page: 1336 ident: CR79 article-title: Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats publication-title: Free Radical Biology & Medicine – volume: 28 start-page: 684 issue: 4 year: 2018 end-page: 688 ident: CR92 article-title: Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice publication-title: Bioorganic & Medicinal Chemistry Letters – volume: 126 start-page: 137 issue: 2 year: 1997 end-page: 145 ident: CR12 article-title: Nonalcoholic steatohepatitis publication-title: Annals of Internal Medicine – volume: 170 start-page: 339 issue: 5 year: 2014 end-page: 343 ident: CR54 article-title: Mitochondrial dysfunctions in Parkinson’s disease publication-title: Revista de Neurologia – volume: 267 start-page: 1 year: 2017 end-page: 10 ident: CR83 article-title: Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats publication-title: Toxicology Letters – volume: 21 start-page: 2383 issue: 10 year: 2002 end-page: 2396 ident: CR56 article-title: Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence publication-title: The EMBO Journal – volume: 298 start-page: E419 issue: 3 year: 2010 end-page: E428 ident: CR48 article-title: SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity publication-title: American Journal of Physiology. Endocrinology and Metabolism – volume: 29 start-page: 1316 issue: 12 year: 2015 end-page: 1325 ident: CR66 article-title: Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol publication-title: Genes & Development – volume: 338 start-page: 17 issue: 1 year: 2004 end-page: 31 ident: CR1 article-title: Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis publication-title: Journal of Molecular Biology – ident: CR13 – volume: 426 start-page: 526 issue: 3 year: 2014 end-page: 541 ident: CR7 article-title: Structural and functional analysis of human SIRT1 publication-title: Journal of Molecular Biology – volume: 107 start-page: 7 issue: 1 year: 2001 end-page: 11 ident: CR18 article-title: NF-κB: A key role in inflammatory diseases publication-title: The Journal of Clinical Investigation – volume: 146 start-page: 801 issue: 3 year: 2014 end-page: 811 ident: CR28 article-title: Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver publication-title: Gastroenterology. – volume: 32 start-page: 421 year: 2009 end-page: 423 ident: CR43 article-title: Elevated levels of the anti- inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: The Whitehall II study publication-title: Diabetes Care – volume: 5 start-page: 16013 year: 2015 ident: CR70 article-title: Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease publication-title: Scientific Reports – volume: 467 start-page: 638 issue: 4 year: 2015 end-page: 644 ident: CR74 article-title: Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells publication-title: Biochemical and Biophysical Research Communications – volume: 60 start-page: 308 issue: 3 year: 2006 end-page: 314 ident: CR30 article-title: Oxidative stress in type 2 diabetes: The role of fasting and postprandial glycaemia publication-title: International Journal of Clinical Practice – volume: 7 start-page: 1 issue: 1 year: 2017 end-page: 1 ident: CR69 article-title: Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells publication-title: Scientific Reports – volume: 553 start-page: 72 year: 2013 end-page: 77 ident: CR64 article-title: Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway publication-title: Neuroscience Letters – volume: 17 start-page: 138 issue: 2 year: 1997 end-page: 139 ident: CR35 article-title: Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1 publication-title: Nature Genetics – volume: 1 start-page: 70 year: 2011 ident: CR87 article-title: SRT1720 improves survival and healthspan of obese mice publication-title: Scientific Reports – volume: 20 start-page: 1255 issue: 10 year: 2005 end-page: 1263 ident: CR52 article-title: A systematic review of prevalence studies of dementia in Parkinson’s disease publication-title: Movement disorders: official journal of the Movement Disorder Society – volume: 15 start-page: 675 issue: 5 year: 2012 end-page: 690 ident: CR4 article-title: SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function publication-title: Cell Metabolism – volume: 460 start-page: 587 issue: 7255 year: 2009 end-page: 591 ident: CR2 article-title: Recent progress in the biology and physiology of sirtuins publication-title: Nature. – volume: 30 start-page: 3207 issue: 29 year: 2011 end-page: 3221 ident: CR55 article-title: The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor publication-title: Oncogene. – volume: 20 start-page: 13079 issue: 36 year: 2014 ident: 1242_CR25 publication-title: World journal of gastroenterology: WJG doi: 10.3748/wjg.v20.i36.13079 – volume: 286 start-page: 327 issue: 3 year: 2001 ident: 1242_CR44 publication-title: Jama. doi: 10.1001/jama.286.3.327 – volume: 23 start-page: 2369 issue: 12 year: 2004 ident: 1242_CR20 publication-title: The EMBO Journal doi: 10.1038/sj.emboj.7600244 – volume: 6 start-page: 682 issue: 7 year: 2010 ident: 1242_CR29 publication-title: International Journal of Biological Sciences doi: 10.7150/ijbs.6.682 – ident: 1242_CR39 doi: 10.1371/journal.pone.0120849 – volume: 343 start-page: 36 issue: 1–2 year: 2014 ident: 1242_CR50 publication-title: Journal of the Neurological Sciences doi: 10.1016/j.jns.2014.05.003 – volume: 426 start-page: 526 issue: 3 year: 2014 ident: 1242_CR7 publication-title: Journal of Molecular Biology doi: 10.1016/j.jmb.2013.10.009 – volume: 8 start-page: 1 issue: 1 year: 2018 ident: 1242_CR90 publication-title: Scientific Reports doi: 10.1038/s41598-018-35687-8 – volume: 146 start-page: 801 issue: 3 year: 2014 ident: 1242_CR28 publication-title: Gastroenterology. doi: 10.1053/j.gastro.2013.11.008 – volume: 9 start-page: 934 issue: 9 year: 2013 ident: 1242_CR36 publication-title: International Journal of Biological Sciences doi: 10.7150/ijbs.7529 – ident: 1242_CR61 doi: 10.1371/journal.pone.0001376 – volume: 30 start-page: 4712 issue: 19 year: 2010 ident: 1242_CR23 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.00657-10 – volume: 56 start-page: 2356 issue: 9 year: 2007 ident: 1242_CR45 publication-title: Diabetes. doi: 10.2337/db06-1650 – volume: 148 start-page: 387 issue: 3 year: 2012 ident: 1242_CR65 publication-title: Cell. doi: 10.1016/j.cell.2012.01.032 – volume: 29 start-page: 1316 issue: 12 year: 2015 ident: 1242_CR66 publication-title: Genes & Development doi: 10.1101/gad.265462.115 – ident: 1242_CR51 doi: 10.3410/M3-7 – volume: 44 start-page: 203 issue: 2 year: 2011 ident: 1242_CR6 publication-title: Molecular Cell doi: 10.1016/j.molcel.2011.07.038 – volume: 35 start-page: 807 issue: 2 year: 2015 ident: 1242_CR58 publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.2939-14.2015 – volume: 553 start-page: 72 year: 2013 ident: 1242_CR64 publication-title: Neuroscience Letters doi: 10.1016/j.neulet.2013.08.020 – volume: 338 start-page: 17 issue: 1 year: 2004 ident: 1242_CR1 publication-title: Journal of Molecular Biology doi: 10.1016/j.jmb.2004.02.006 – volume: 6 start-page: 38186 year: 2016 ident: 1242_CR68 publication-title: Scientific Reports doi: 10.1038/srep38186 – volume: 12 start-page: 1763 issue: 12 year: 1998 ident: 1242_CR34 publication-title: Genes & Development doi: 10.1101/gad.12.12.1763 – volume: 52 start-page: 812 issue: 3 year: 2003 ident: 1242_CR41 publication-title: Diabetes. doi: 10.2337/diabetes.52.3.812 – volume: 108 start-page: 1607 issue: 5 year: 1995 ident: 1242_CR11 publication-title: Gastroenterology. doi: 10.1016/0016-5085(95)90724-6 – volume: 292 start-page: 18821 issue: 46 year: 2017 ident: 1242_CR19 publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M117.813980 – volume: 10 start-page: 443 year: 2018 ident: 1242_CR81 publication-title: Frontiers in Molecular Neuroscience doi: 10.3389/fnmol.2017.00443 – ident: 1242_CR13 – volume: 29 start-page: 1754 issue: 11 year: 2008 ident: 1242_CR49 publication-title: Neurobiology of Aging doi: 10.1016/j.neurobiolaging.2007.04.013 – volume: 277 start-page: 30010 issue: 33 year: 2002 ident: 1242_CR38 publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M202066200 – volume: 144 start-page: 457 issue: 3 year: 2012 ident: 1242_CR14 publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2012.09.044 – volume: 21 start-page: 2383 issue: 10 year: 2002 ident: 1242_CR56 publication-title: The EMBO Journal doi: 10.1093/emboj/21.10.2383 – volume: 1822 start-page: 1815 issue: 11 year: 2012 ident: 1242_CR37 publication-title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease doi: 10.1016/j.bbadis.2012.08.009 – volume: 48 start-page: 507 issue: 3 year: 1999 ident: 1242_CR33 publication-title: Diabetes. doi: 10.2337/diabetes.48.3.507 – volume: 60 start-page: 308 issue: 3 year: 2006 ident: 1242_CR30 publication-title: International Journal of Clinical Practice doi: 10.1111/j.1368-5031.2006.00825.x – volume: 371 start-page: 606 issue: 6498 year: 1994 ident: 1242_CR32 publication-title: Nature. doi: 10.1038/371606a0 – volume: 282 start-page: 6823 issue: 9 year: 2007 ident: 1242_CR5 publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M609554200 – volume: 105 start-page: 9793 issue: 28 year: 2008 ident: 1242_CR24 publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0802917105 – volume: 67 start-page: 115 issue: S 01 year: 2005 ident: 1242_CR42 publication-title: Das Gesundheitswesen doi: 10.1055/s-2005-858252 – volume: 30 start-page: 49 issue: 1 year: 2012 ident: 1242_CR40 publication-title: Cardiovascular Therapeutics doi: 10.1111/j.1755-5922.2010.00218.x – volume: 30 start-page: 3207 issue: 29 year: 2011 ident: 1242_CR55 publication-title: Oncogene. doi: 10.1038/onc.2011.35 – volume: 8 start-page: 1 issue: 1 year: 2017 ident: 1242_CR8 publication-title: Nature Communications doi: 10.1038/s41467-016-0009-6 – volume: 460 start-page: 587 issue: 7255 year: 2009 ident: 1242_CR2 publication-title: Nature. doi: 10.1038/nature08197 – volume: 151 start-page: 2504 issue: 6 year: 2010 ident: 1242_CR22 publication-title: Endocrinology. doi: 10.1210/en.2009-1013 – volume: 20 start-page: 1255 issue: 10 year: 2005 ident: 1242_CR52 publication-title: Movement disorders: official journal of the Movement Disorder Society doi: 10.1002/mds.20527 – volume: 24 start-page: 183 issue: 1 year: 2006 ident: 1242_CR63 publication-title: Neurobiology of Disease doi: 10.1016/j.nbd.2006.06.013 – volume: 7 start-page: 1 issue: 1 year: 2017 ident: 1242_CR75 publication-title: Scientific Reports doi: 10.1038/s41598-016-0028-x – volume: 29 start-page: 1363 issue: 5 year: 2009 ident: 1242_CR47 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.00705-08 – volume: 36 start-page: 592 issue: 5 year: 2004 ident: 1242_CR80 publication-title: Free Radical Biology & Medicine doi: 10.1016/j.freeradbiomed.2003.11.023 – ident: 1242_CR27 doi: 10.1371/journal.pone.0059122 – volume: 23 start-page: 183 issue: 2 year: 2008 ident: 1242_CR53 publication-title: Movement Disorders doi: 10.1002/mds.21803 – volume: 96 start-page: 857 issue: 6 year: 1999 ident: 1242_CR57 publication-title: cell doi: 10.1016/S0092-8674(00)80595-4 – volume: 5 start-page: 16013 year: 2015 ident: 1242_CR70 publication-title: Scientific Reports doi: 10.1038/srep16013 – volume: 59 start-page: 1905 issue: 10 year: 2015 ident: 1242_CR73 publication-title: Molecular Nutrition & Food Research doi: 10.1002/mnfr.201500144 – volume: 59 start-page: 265 issue: 4 year: 1984 ident: 1242_CR91 publication-title: Journal of Neural Transmission doi: 10.1007/BF01255596 – volume: 126 start-page: 137 issue: 2 year: 1997 ident: 1242_CR12 publication-title: Annals of Internal Medicine doi: 10.7326/0003-4819-126-2-199701150-00008 – volume: 2016 start-page: 1 year: 2016 ident: 1242_CR76 publication-title: Oxidative Medicine and Cellular Longevity – volume: 53 start-page: 296 issue: 3 year: 2013 ident: 1242_CR3 publication-title: Critical Reviews in Food Science and Nutrition doi: 10.1080/10408398.2010.529624 – volume: 107 start-page: 7 issue: 1 year: 2001 ident: 1242_CR18 publication-title: The Journal of Clinical Investigation doi: 10.1172/JCI11830 – volume: 47 start-page: 1310 issue: 9 year: 2009 ident: 1242_CR26 publication-title: Free Radical Biology & Medicine doi: 10.1016/j.freeradbiomed.2009.06.030 – volume: 18 start-page: 1151 issue: 13 year: 2018 ident: 1242_CR71 publication-title: Mini Reviews in Medicinal Chemistry doi: 10.2174/1389557516666160620095103 – volume: 467 start-page: 638 issue: 4 year: 2015 ident: 1242_CR74 publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2015.10.094 – ident: 1242_CR15 – volume: 7 start-page: 53 year: 2013 ident: 1242_CR60 publication-title: Frontiers in Cellular Neuroscience – volume: 267 start-page: 1 year: 2017 ident: 1242_CR83 publication-title: Toxicology Letters doi: 10.1016/j.toxlet.2016.12.010 – volume: 43 start-page: 517 issue: 4 year: 2019 ident: 1242_CR85 publication-title: Journal of Ginseng Research doi: 10.1016/j.jgr.2018.02.002 – volume: 38 start-page: 349 issue: 5 year: 2012 ident: 1242_CR77 publication-title: Biofactors. doi: 10.1002/biof.1032 – volume: 15 start-page: 675 issue: 5 year: 2012 ident: 1242_CR4 publication-title: Cell Metabolism doi: 10.1016/j.cmet.2012.04.003 – volume: 19 start-page: 403 issue: 4 year: 2009 ident: 1242_CR78 publication-title: Expert Opinion on Therapeutic Patents doi: 10.1517/13543770902762893 – ident: 1242_CR89 doi: 10.1371/journal.pone.0134391 – volume: 37 start-page: 154 issue: 1 year: 2002 ident: 1242_CR10 publication-title: Journal of Hepatology doi: 10.1016/S0168-8278(02)00099-5 – volume: 52 start-page: 2896 issue: 12 year: 2003 ident: 1242_CR31 publication-title: Diabetes. doi: 10.2337/diabetes.52.12.2896 – volume: 450 start-page: 712 issue: 7170 year: 2007 ident: 1242_CR88 publication-title: Nature. doi: 10.1038/nature06261 – volume: 29 start-page: 664 issue: 3 year: 1999 ident: 1242_CR9 publication-title: Hepatology. doi: 10.1002/hep.510290347 – volume: 298 start-page: E419 issue: 3 year: 2010 ident: 1242_CR48 publication-title: American Journal of Physiology. Endocrinology and Metabolism doi: 10.1152/ajpendo.00417.2009 – volume: 208 start-page: 1 issue: 1 year: 2007 ident: 1242_CR62 publication-title: Experimental Neurology doi: 10.1016/j.expneurol.2007.07.004 – volume: 409 start-page: 144 year: 2018 ident: 1242_CR84 publication-title: Toxicology. doi: 10.1016/j.tox.2018.08.010 – volume: 51 start-page: 1329 issue: 7 year: 2011 ident: 1242_CR79 publication-title: Free Radical Biology & Medicine doi: 10.1016/j.freeradbiomed.2011.06.017 – volume: 28 start-page: 684 issue: 4 year: 2018 ident: 1242_CR92 publication-title: Bioorganic & Medicinal Chemistry Letters doi: 10.1016/j.bmcl.2018.01.021 – volume: 339 start-page: 1216 issue: 6124 year: 2013 ident: 1242_CR67 publication-title: Science. doi: 10.1126/science.1231097 – volume: 137 start-page: 47 issue: 1 year: 2009 ident: 1242_CR59 publication-title: Cell. doi: 10.1016/j.cell.2009.01.038 – volume: 17 start-page: 138 issue: 2 year: 1997 ident: 1242_CR35 publication-title: Nature Genetics doi: 10.1038/ng1097-138 – volume: 32 start-page: 421 year: 2009 ident: 1242_CR43 publication-title: Diabetes Care doi: 10.2337/dc08-1161 – volume: 7 start-page: 1 issue: 1 year: 2017 ident: 1242_CR69 publication-title: Scientific Reports doi: 10.1038/s41598-016-0028-x – volume: 1852 start-page: 1209 issue: 6 year: 2015 ident: 1242_CR82 publication-title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease doi: 10.1016/j.bbadis.2015.01.012 – volume: 63 start-page: 1698 issue: 5 year: 2014 ident: 1242_CR46 publication-title: Diabetes. doi: 10.2337/db13-0863 – volume: 1 start-page: 70 year: 2011 ident: 1242_CR87 publication-title: Scientific Reports doi: 10.1038/srep00070 – volume: 17 start-page: 1575 issue: 9 year: 2016 ident: 1242_CR17 publication-title: International Journal of Molecular Sciences doi: 10.3390/ijms17091575 – volume: 9 start-page: 1 issue: 7 year: 2018 ident: 1242_CR93 publication-title: Cell Death & Disease – volume: 73 start-page: 1969 issue: 10 year: 2016 ident: 1242_CR16 publication-title: Cellular and Molecular Life Sciences doi: 10.1007/s00018-016-2161-x – volume: 103 start-page: 1585 year: 2018 ident: 1242_CR72 publication-title: Biomedicine & Pharmacotherapy doi: 10.1016/j.biopha.2018.05.003 – volume: 37 start-page: 813 issue: 6 year: 2014 ident: 1242_CR86 publication-title: Archives of Pharmacal Research doi: 10.1007/s12272-013-0223-2 – volume: 296 start-page: G1047 issue: 5 year: 2009 ident: 1242_CR21 publication-title: American Journal of Physiology. Gastrointestinal and Liver Physiology doi: 10.1152/ajpgi.00016.2009 – volume: 170 start-page: 339 issue: 5 year: 2014 ident: 1242_CR54 publication-title: Revista de Neurologia – reference: 33829418 - Inflammation. 2021 Apr 8;:
SSID	ssj0008983
Score	2.6458197
SecondaryResourceType	review_article
Snippet	Silent information regulator 1 ( SIRT1 ) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several... Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several... AbstractSilent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of...
SourceID	proquest pubmed crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	1589
SubjectTerms	Biomedical and Life Sciences Biomedicine Deacetylation Diabetes mellitus Fatty liver Forkhead protein Gene deletion Gene expression Histones Homeobox Immunology Inflammation Interleukin 1 Internal Medicine Liver diseases NAD Neurodegenerative diseases NF-κB protein Oxidative stress Pancreas Pathology Pharmacology/Toxicology Reactive oxygen species Review Rheumatology SIRT1 protein Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors
SummonAdditionalLinks	– databaseName: SpringerLink Journals (ICM) dbid: U2A link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dSxwxEB_aK0hfilatq2eJ4EOLLly-djePIh62YIX7gHtySbIJHMhu0RP8853sl8ppoa-bZDbMJJPfMF8Ax0IyzRw1sZehhZmXRWwck7HPjOKeumxUR7tf_Uku5-L3Qi7apLD7Ltq9c0nWmvpFshtC6ziYO6hUBYvVR_gk0XYPgVxzdtbr30w1xTd5ghpGqbRNlXmbxuvnaA1jrvlH62dnvAlfWrxIzhoBb8EHV36FjavWI74NN5Pq1pHKk-kyvB-kTS8K7CaTps98dUco-TH9NZnRn2TZf8bfkevHZVFX_ibTOmeE6LIIJPCYNDR2YD6-mJ1fxm3PhNiiobuKqeGpSTJuvS08ZVpxXUjvxcjpUPtP6ZGwhRk5aXUqCutSnOlUYvEe8lQpzXdhUFal2wOSOcYTp0xaUCWs1kah5So1D3E01jIfAe1Yl9u2oHjoa3GbP5dCDuzOkd15ze5cRXDSr_nblNP45-xhJ5G8vVr3OeIRhJkIM5K3hyVCVCHRzIzgqB_GOxMcIbp01UMggapLMJGmEXxrBN3vBgFm2A2N4LST_DPx97e6_3_TD-AzC6ewjgocwmB19-AOEd2szPf6MD8BBKns0g priority: 102 providerName: Springer Nature
Title	Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation
URI	https://link.springer.com/article/10.1007/s10753-020-01242-9 https://www.ncbi.nlm.nih.gov/pubmed/32410071 https://www.proquest.com/docview/2440541856 https://www.proquest.com/docview/2556545010 https://www.proquest.com/docview/2404042477
Volume	43
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Za9wwEB7aBEpfStMrbg5U6ENLa2pJvvRUtsumaUvSspuF7UuNJEuwEOwcG-jP74ytdSg5XmyQ5LEYjWa-0TED8DbNhBaOm9hnlMLMZ3VsnMhiXxolPXdl0p12PzrOD-fp90W2CAtul-FY5Vondoq6bi2tkX-iUFlo7dF9-Hx2HlPWKNpdDSk0HsImhS4jqS4Wg8OVlKoPwylz1DVKFeHSTLg6h0A9JucJVXQqYvW_YbqBNm_slHYG6OApPAnIkY36od6CB655Bo-Owt74c_gzbU8daz2bLcmSsHDRiBjPpn3G-faCcfZu9m16wt-z5VCMv2M__y7rLgY4m3W3R5huaiKBAtPTeAHzg8nJ-DAO2RNiiy7vKuZGFiYvpfW29lxoJXWdeZ8mTlMUQKWT1NYmcZnVRVpbV2BLp3KLM1IWSmn5EjaatnHbwEonZO6UKWquUqu1UejDZlrSiRprhY-Ar1lX2RBanDJcnFbXQZGJ3RWyu-rYXakIPgzfnPWBNe5tvbsekSpMsssKkQkCTgQc-e3Vg8RE8GaoxtlDWyK6ce0VkUAlloq0KCJ41Q_00BuEmtQbHsHH9chfE7-7q6_v78sOPBYkdd15wF3YWF1cuT3ENSuz3wnvPmyOvv7-McH3l8nxrymWjvMxPudi9A-QzvTf
linkProvider	ProQuest
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1ra9RAcKgV1C9SXzVadQUFRYPJZpPNfhARtdzZXoW7K9wn080-4KAktb2i_qn-RmfyKlLtt37NbibLzOw8Mi-AFyLlmru4DH1KI8x8asPS8TT0eakSH7s8arLdJ3vZaF98XaSLNTjra2EorbKXiY2gtrWhf-TvqFUWant0Hz4c_QhpahRFV_sRGi1b7LjfP9FlO3k__oz0fcn59pf5p1HYTRUIDbqCqzAuE1lmeWK8sT7mWiXapt6LyGnqjqd0JIwtI5caLYU1TuJOpzKDnJpIpXSCcK_BdVS8ETl7cjE4eFGu2rafSYayTSnZFel0pXroGITkrKFKEDxUfyvCC9bthchso_C2N-B2Z6myjy1r3YE1V92FG5MuFn8Pvk_rQ8dqz2ZL0lysK2wiQrNpO-G-PmYxezUbT-fxa7YcHuPn2LdfS9v0HGezplqF6coSCGTQFsZ92L8SvD6A9aqu3ENgueNJ5lQpbayE0bpU6DOnOqEMHmO4DyDuUVeYrpU5TdQ4LM6bMBO6C0R30aC7UAG8Gd45aht5XLp7q6dI0V3qkwItITRw0cDJ_r08cGgAz4dlvK0UgtGVq08JBApNwYWUAWy2hB5Og6YtnSYO4G1P-XPg_z_qo8vP8gxujuaT3WJ3vLfzGG5x4sAmF3EL1lfHp-4J2lSr8mnDyAwOrvrm_AGrMS6X
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1dT9RAcIJHQnwx4mcVdU000WjDdbftdh-IUeHCiZzkDhKerNvtbnIJaRGOqH-NX8dMuy0xKG-8drfTyczsfHTnA-BVnHDNbVSELqERZi4pw8LyJHRZoYSLbDZsst13J-n2QfzlMDlcgvOuFobSKjud2Cjqsjb0j3ydWmWhtcfwYd35tIi9zdGH458hTZCim9ZunEYrIjv2zy8M3043xpvI69ecj7b2P2-HfsJAaDAsXIRRIWSRZsI4U7qIayV0mTgXD62mTnlKD2NTFkObGC3j0liJO61KDUqtkEppgXBvwbKkqGgAy5-2JnvT3g5kqm0CKlLUdEpJX7LjC_cwTAgpdEMDEfNQ_W0Wr_i6V-5pG_M3ugt3vN_KPraCtgpLtroHK7v-Zv4-fJ_WR5bVjs3mZMeYL3MitrNpO---PmERezMbT_ejt2zeP8bPsW-_52XTgZzNmtoVpquSQKC4tjAewMGNUPYhDKq6so-BZZaL1KpClpGKjdaFwgg60YLyeYzhLoCoI11ufGNzmq9xlF-2ZCZy50juvCF3rgJ4179z3Lb1uHb3WseR3B_x0xz9InR30d1J_73cy2sAL_tlPLt0IaMrW58RCFShMY-lDOBRy-geG3R0CZsogPcd5y-B_x_VJ9fj8gJW8NTkX8eTnadwm5MANomJazBYnJzZZ-hgLYrnXpIZ_Ljpw3MBLVc0Mg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+Silent+Information+Regulator+1+%28SIRT1%29+in+Regulating+Oxidative+Stress+and+Inflammation&rft.jtitle=Inflammation&rft.au=Singh%2C+Vivek&rft.au=Saba%2C+Ubaid&rft.date=2020-10-01&rft.pub=Springer+Nature+B.V&rft.issn=0360-3997&rft.eissn=1573-2576&rft.volume=43&rft.issue=5&rft.spage=1589&rft.epage=1598&rft_id=info:doi/10.1007%2Fs10753-020-01242-9&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0360-3997&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0360-3997&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0360-3997&client=summon