Current views on etiology, diagnosis, epidemiology and gene therapy of maturity onset diabetes in the young

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1497298
• Main Authors: Dzhemileva, Lilya U., Zakharova, Elena N., Goncharenko, Anna O., Vorontsova, Maria V., Rumyantsev, S. A., Mokrysheva, Natalia G., Loguinova, Marina Y., Chekhonin, Vladimir P.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.01.2025
• Subjects: AAV-vectors; Adolescent; Adult; autosomal dominant inheritance; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - etiology; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - therapy; diabetes monogenic forms; Endocrinology; European and Asian populations; gene therapy; Genetic Therapy - methods; Hepatocyte Nuclear Factor 1-alpha - genetics; Hepatocyte Nuclear Factor 4 - genetics; Humans; maturity-onset diabetes of the young (MODY); Mutation; Young Adult; European and Asian populations; gene therapy; AAV-vectors; maturity-onset diabetes of the young (MODY); diabetes monogenic forms; autosomal dominant inheritance

MODY, or maturity-onset diabetes of the young, is a group of monogenic diseases characterized by autosomal dominant inheritance of a non-insulin-dependent form of diabetes that classically manifests in adolescence or in young adults under 25 years of age. MODY is a rare cause of diabetes, accounting...