Efficacy-oriented compatibility for component-based Chinese medicine
Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and ＂polypills＂, as the frontier in new drug...
Saved in:
| Published in | Acta pharmacologica Sinica Vol. 36; no. 6; pp. 654 - 658 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.06.2015
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1671-4083 1745-7254 |
| DOI | 10.1038/aps.2015.8 |
Cover
| Abstract | Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and ＂polypills＂, as the frontier in new drug development. A traditional Chinese medicine （TCM） prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines. |
|---|---|
| AbstractList | Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and "polypills", as the frontier in new drug development. A traditional Chinese medicine (TCM) prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines. Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and ＂polypills＂, as the frontier in new drug development. A traditional Chinese medicine （TCM） prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines. |
| Author | Jun-hua ZHANG Yan ZHU Xiao-hui FAN Bo-li ZHANG |
| AuthorAffiliation | Tianjin State Key Laboratory of Modem Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China Chinese Academy of Chinese Medical Science,Beijing 100700, China |
| Author_xml | – sequence: 1 givenname: Jun-hua surname: Zhang fullname: Zhang, Jun-hua organization: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine – sequence: 2 givenname: Yan surname: Zhu fullname: Zhu, Yan organization: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine – sequence: 3 givenname: Xiao-hui surname: Fan fullname: Fan, Xiao-hui organization: Pharmaceutical Informatics Institute, Zhejiang University – sequence: 4 givenname: Bo-li surname: Zhang fullname: Zhang, Bo-li email: zhangbolipr@163.com organization: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Chinese Academy of Chinese Medical Science |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25864650$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkUtLAzEUhYMo1tfGHyBFd8rUvCezEaQ-QXCj65BJkzYyTWoyFfrvzdhaqnSVS-53zzncewh2ffAGgFMEBwgSca1maYAhYgOxAw5QSVlRYkZ3c81LVFAoSA8cpvQBIcEEVfugh5nglDN4AO7urXVa6UURojO-NaO-DtOZal3tGtcu-jbEn59s6duiVikTw4nzJpn-1IyczuUx2LOqSeZk9R6B94f7t-FT8fL6-Dy8fSk05VVbIEWJZoxqbqngiOeQlCukjKVWa65qXlcKmxqaUaUYocJiDi2BlGFRalyTI3Cz1J3N6-ytc6KoGjmLbqriQgbl5N-OdxM5Dl-SsooiUWaBi5VADJ9zk1r5EebR58wSccFQKSjnmTrbtFnr_24tA3AJ6BhSisZK7dq8stC5ukYiKLvDyHwY2R1Gijxy-W_kV3UrfLWEU4b82MSNmNvo85X0JPjxZx5Ya3PerY5iTL4Bg0KpeQ |
| CitedBy_id | crossref_primary_10_1016_j_biopha_2020_110939 crossref_primary_10_1016_j_phymed_2021_153475 crossref_primary_10_3389_fphar_2024_1333167 crossref_primary_10_1016_j_pharmthera_2020_107680 crossref_primary_10_1016_j_phrs_2021_105460 crossref_primary_10_1016_j_intimp_2024_112044 crossref_primary_10_1039_D3NR06102G crossref_primary_10_1007_s11655_020_3481_0 crossref_primary_10_1155_2022_3360771 crossref_primary_10_2147_DDDT_S477381 crossref_primary_10_1155_2021_5824956 crossref_primary_10_1016_j_jep_2022_115902 crossref_primary_10_1155_2016_6012761 crossref_primary_10_1186_s13020_021_00496_1 crossref_primary_10_1080_10715762_2017_1290233 crossref_primary_10_1016_j_jep_2022_115301 crossref_primary_10_1016_j_phymed_2021_153522 crossref_primary_10_1186_s40199_017_0188_7 crossref_primary_10_4103_wjtcm_wjtcm_64_21 crossref_primary_10_1142_S0192415X1550086X crossref_primary_10_1530_ERC_18_0393 crossref_primary_10_1016_j_indcrop_2024_120279 crossref_primary_10_1016_j_jep_2018_08_024 crossref_primary_10_1002_cem_2924 crossref_primary_10_1186_s12951_022_01490_x crossref_primary_10_3389_fphar_2020_598744 crossref_primary_10_4103_wjtcm_wjtcm_6_20 crossref_primary_10_1097_MD_0000000000013052 crossref_primary_10_3390_biom14091138 crossref_primary_10_2217_nnm_2018_0479 crossref_primary_10_1038_aps_2015_33 crossref_primary_10_3389_fphar_2019_01046 crossref_primary_10_1016_j_jtcms_2020_05_006 crossref_primary_10_1002_bmc_5256 crossref_primary_10_1016_j_jep_2019_112528 crossref_primary_10_1016_j_phymed_2022_154503 crossref_primary_10_1016_j_prmcm_2023_100349 crossref_primary_10_3389_fphar_2025_1558916 crossref_primary_10_1042_BSR20180429 crossref_primary_10_1016_j_phymed_2023_154980 crossref_primary_10_3389_fimmu_2022_1007341 crossref_primary_10_1038_s41598_017_07659_x crossref_primary_10_1016_j_fitote_2025_106429 crossref_primary_10_3390_ijms19113506 crossref_primary_10_1016_j_jep_2023_116539 crossref_primary_10_3389_fphar_2024_1380977 crossref_primary_10_1038_aps_2017_137 crossref_primary_10_1016_j_phymed_2024_155506 crossref_primary_10_1016_j_jep_2022_115641 crossref_primary_10_3389_fchem_2023_1142287 crossref_primary_10_1016_j_eng_2025_03_014 crossref_primary_10_1016_j_phymed_2022_154534 crossref_primary_10_1016_j_compbiolchem_2020_107402 crossref_primary_10_1155_2020_4263591 crossref_primary_10_1186_s13020_024_00917_x crossref_primary_10_1016_j_jep_2018_11_043 crossref_primary_10_1016_j_jep_2019_112372 crossref_primary_10_1016_j_joim_2020_04_004 crossref_primary_10_3389_fphar_2021_791097 crossref_primary_10_3390_molecules23071829 crossref_primary_10_1016_j_biopha_2022_113325 crossref_primary_10_1016_j_jep_2025_119340 crossref_primary_10_3390_nano11102757 crossref_primary_10_1155_2023_7982927 crossref_primary_10_3389_fphar_2022_888684 crossref_primary_10_1016_j_jep_2020_112687 crossref_primary_10_1016_j_jep_2022_115515 crossref_primary_10_1186_s12929_023_00923_5 crossref_primary_10_1016_j_phymed_2022_154619 |
| Cites_doi | 10.1038/35019019 10.1016/j.ijcard.2008.11.210 10.2174/157016307781115494 10.1136/bmj.326.7404.1419 10.1073/pnas.0404315101 10.1016/S0140-6736(09)60611-5 10.1038/nrg1272 10.1016/j.fitote.2010.11.017 10.1039/c3np70052f 10.1016/S1359-6446(04)03316-1 10.1038/nchembio.118 10.1016/j.jchromb.2007.12.004 10.1016/j.drudis.2013.01.008 10.1126/science.303.5665.1795 10.1371/journal.pone.0095004 10.1016/j.drudis.2011.12.006 10.2174/138620710793360257 10.1124/mi.7.4.8 10.1186/1749-8546-9-24 10.1177/1087057108319644 10.1056/NEJMcibr072593 10.1186/1471-2105-7-354 10.1093/bioinformatics/btn182 10.1093/nar/gkn296 10.1016/j.tips.2005.02.007 10.1155/2013/738391 |
| ContentType | Journal Article |
| Copyright | CPS and SIMM 2015 Copyright Nature Publishing Group Jun 2015 Copyright © 2015 CPS and SIMM 2015 CPS and SIMM |
| Copyright_xml | – notice: CPS and SIMM 2015 – notice: Copyright Nature Publishing Group Jun 2015 – notice: Copyright © 2015 CPS and SIMM 2015 CPS and SIMM |
| DBID | 2RA 92L CQIGP W91 ~WA AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7QR 7T5 7TK 7TO 7U9 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 5PM |
| DOI | 10.1038/aps.2015.8 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) |
| DatabaseTitleList | MEDLINE ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| DocumentTitleAlternate | Efficacy-oriented compatibility for component-based Chinese medicine |
| EISSN | 1745-7254 |
| EndPage | 658 |
| ExternalDocumentID | PMC4594187 3702881051 25864650 10_1038_aps_2015_8 665287422 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GroupedDBID | --- -05 -0E -Q- -S~ .3N 0R~ 188 1OC 23M 2RA 2WC 31~ 36B 3V. 4.4 406 53G 5GY 5VR 5VS 6J9 70F 7X7 8-1 88E 8FI 8FJ 8R4 8R5 8RM 92L 92M 9D9 9DE A8Z AADWK AANZL AATNV AAWBL AAYFA AAYJO AAZLF ABAWZ ABGIJ ABKZE ABUWG ACAOD ACBMV ACBRV ACBYP ACGFO ACGFS ACIGE ACIWK ACKTT ACPRK ACRQY ACTTH ACVWB ACXQS ACZOJ ADBBV ADFRT ADHDB ADMDM ADQMX ADRAZ ADYYL AEDAW AEFTE AEJRE AENEX AESKC AEVLU AEXYK AFBPY AFKRA AFNRJ AFRAH AFSHS AFUIB AFZJQ AGAYW AGEZK AGGBP AGHAI AHMBA AHSBF AILAN AJAOE AJCLW AJDOV AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AMRJV AMYLF AOIJS AXYYD BAWUL BBNVY BENPR BFHJK BHPHI BKKNO BPHCQ BVXVI C1A CAG CAJEE CAJUS CCEZO CCPQU CHBEP CIEJG CO8 COF CQIGP CS3 CW9 DIK DNIVK DPUIP E3Z EBLON EBS EE. EIOEI EJD EMB EMOBN ESTFP F5P FA0 FDQFY FERAY FIZPM FSGXE FYUFA GX1 HCIFZ HH5 HMCUK HYE HZI HZ~ IWAJR JSO JUIAU JZLTJ K97 KQ8 LH4 LW6 M1P M48 M7P MK0 NQJWS NXXTH NYICJ O9- OK1 OVD P2P P6G PQQKQ PROAC PSQYO Q-- Q-4 Q2X R-E RNT RNTTT RPM RT5 S.. SNX SNYQT SOHCF SRMVM SV3 SWTZT T8U TAOOD TBHMF TDRGL TEORI TR2 TSG U1F U1G U5E U5O UKHRP UZ5 W91 ~88 ~NG ~WA -SE AACDK AASML AAXDM ABAKF ABZZP ACMJI AEFQL AEMSY AFBBN AGQEE AIGIU ALIPV FIGPU LGEZI LOTEE NADUK ROL AAYXX ABBRH ABDBE ABFSG ACMFV ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT SOJ CGR CUY CVF ECM EIF NPM 7QP 7QR 7T5 7TK 7TO 7U9 7XB 8FD 8FE 8FH 8FK ABRTQ AZQEC DWQXO FR3 GNUQQ H94 K9. LK8 M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS 5PM |
| ID | FETCH-LOGICAL-c469t-1a43c554c6f4861625446a1aef4fcc6ab6b9a2eb0ed9a5348f260f3045287c2b3 |
| IEDL.DBID | M48 |
| ISSN | 1671-4083 |
| IngestDate | Thu Aug 21 14:12:40 EDT 2025 Fri Jul 25 09:09:34 EDT 2025 Thu Apr 03 07:06:21 EDT 2025 Thu Apr 24 22:51:00 EDT 2025 Tue Jul 01 02:18:31 EDT 2025 Fri Feb 21 02:38:47 EST 2025 Wed Feb 14 10:30:17 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | traditional Chinese medicine efficacy-oriented compatibility multi-target drug component-based Chinese medicine |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c469t-1a43c554c6f4861625446a1aef4fcc6ab6b9a2eb0ed9a5348f260f3045287c2b3 |
| Notes | Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and ＂polypills＂, as the frontier in new drug development. A traditional Chinese medicine （TCM） prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines. efficacy-oriented compatibility; component-based Chinese medicine; traditional Chinese medicine; multi-target drug 31-1347/R ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 |
| OpenAccessLink | https://www.nature.com/articles/aps20158.pdf |
| PMID | 25864650 |
| PQID | 1685178466 |
| PQPubID | 28815 |
| PageCount | 5 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4594187 proquest_journals_1685178466 pubmed_primary_25864650 crossref_citationtrail_10_1038_aps_2015_8 crossref_primary_10_1038_aps_2015_8 springer_journals_10_1038_aps_2015_8 chongqing_primary_665287422 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2015-06-01 |
| PublicationDateYYYYMMDD | 2015-06-01 |
| PublicationDate_xml | – month: 06 year: 2015 text: 2015-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: United States – name: Shanghai |
| PublicationTitle | Acta pharmacologica Sinica |
| PublicationTitleAbbrev | Acta Pharmacol Sin |
| PublicationTitleAlternate | Acta Pharmacologica Sinica |
| PublicationYear | 2015 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Sams-Dodd (CR2) 2005; 10 Zhang, Wang (CR3) 2005; 3 Wald, Law (CR23) 2003; 326 Krauthammer, Kaufmann, Gilliam, Rzhetsky (CR9) 2004; 101 Eisenberg, Harris, Littlefield, Cao, Craycroft, Scholten (CR20) 2011; 82 Liu, Li, Cheng (CR19) 2008; 862 Yang, Adelstein, Kassis (CR5) 2012; 17 Barabási, Oltvai (CR12) 2004; 5 Li, Wu, Liu, Jin, Chen, Wang (CR31) 2014; 9 Albert, Jeong, Barabasi (CR11) 2000; 406 Hopkins (CR14) 2008; 4 Xing, Zhang, Li, Zhu, Shang (CR22) 2013; 13 Csermely, Agoston, Pongor (CR13) 2005; 26 Szuromi, Vinson, Marshall (CR4) 2004; 303 Curtis, Henrichand John A (CR18) 2013; 30 Yan, Liu, Liu, Zhao (CR27) 2007; 41 Zhang, Wang, Yu, Liu, Qu, Wang (CR30) 2010; 143 Medina-Franco, Giulianotti, Welmaker, Houghten (CR1) 2013; 18 Cheng, Knox, Young, Stothard, Damaraju, Wishart (CR10) 2008; 36 Wu, Wang, Li, Zhang, Cheng, Fan (CR32) 2014; 9 Mayr, Fuerst (CR17) 2008; 13 Mayer, Janoff (CR15) 2007; 7 Zhu, Zhang, Zhang, Mais, Wang (CR21) 2010; 13 Yusuf, Pais, Afzal, Xavier, Teo (CR24) 2009; 373 CR25 Pospisil, Iyer, Adelstein, Kassis (CR7) 2006; 7 Hong, Wang, Lou, Liu, Qu, Cheng (CR29) 2009; 34 Ramaswamy (CR16) 2007; 357 Ozgür, Vu, Erkan, Radev (CR8) 2008; 24 Sakharkar, Sakharkar (CR6) 2007; 4 Yan, Liu, Liu, Zhao (CR26) 2007; 23 Du, Zhu, Feng, Song, Wei, Ma (CR28) 2008; 28 LD Mayer (BFaps20158_CR15) 2007; 7 FF Yan (BFaps20158_CR26) 2007; 23 JL Medina-Franco (BFaps20158_CR1) 2013; 18 J Curtis (BFaps20158_CR18) 2013; 30 Bl Zhang (BFaps20158_CR3) 2005; 3 P Szuromi (BFaps20158_CR4) 2004; 303 A Ozgür (BFaps20158_CR8) 2008; 24 AL Barabási (BFaps20158_CR12) 2004; 5 X Li (BFaps20158_CR31) 2014; 9 L Wu (BFaps20158_CR32) 2014; 9 R Albert (BFaps20158_CR11) 2000; 406 L Zhang (BFaps20158_CR30) 2010; 143 P Pospisil (BFaps20158_CR7) 2006; 7 DM Eisenberg (BFaps20158_CR20) 2011; 82 MK Sakharkar (BFaps20158_CR6) 2007; 4 Y Zhu (BFaps20158_CR21) 2010; 13 LM Mayr (BFaps20158_CR17) 2008; 13 AL Hopkins (BFaps20158_CR14) 2008; 4 D Cheng (BFaps20158_CR10) 2008; 36 C Hong (BFaps20158_CR29) 2009; 34 NJ Wald (BFaps20158_CR23) 2003; 326 S Yusuf (BFaps20158_CR24) 2009; 373 S Ramaswamy (BFaps20158_CR16) 2007; 357 WX Du (BFaps20158_CR28) 2008; 28 BFaps20158_CR25 F Sams-Dodd (BFaps20158_CR2) 2005; 10 DM Xing (BFaps20158_CR22) 2013; 13 L Liu (BFaps20158_CR19) 2008; 862 M Krauthammer (BFaps20158_CR9) 2004; 101 FF Yan (BFaps20158_CR27) 2007; 41 Y Yang (BFaps20158_CR5) 2012; 17 P Csermely (BFaps20158_CR13) 2005; 26 17634467 - N Engl J Med. 2007 Jul 19;357(3):299-300 10935628 - Nature. 2000 Jul 27;406(6794):378-82 18487273 - Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W399-405 18936753 - Nat Chem Biol. 2008 Nov;4(11):682-90 18182334 - J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):196-204 18660458 - J Biomol Screen. 2008 Jul;13(6):443-8 22178890 - Drug Discov Today. 2012 Feb;17 Suppl:S16-23 19203810 - Int J Cardiol. 2010 Aug 6;143(1):105-9 15718163 - Drug Discov Today. 2005 Jan 15;10(2):139-47 23935677 - Evid Based Complement Alternat Med. 2013;2013:738391 15808341 - Trends Pharmacol Sci. 2005 Apr;26(4):178-82 15471992 - Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15148-53 12829553 - BMJ. 2003 Jun 28;326(7404):1419 21108995 - Fitoterapia. 2011 Jan;82(1):17-33 16857057 - BMC Bioinformatics. 2006;7:354 25342960 - Chin Med. 2014 Sep 16;9:24 14735121 - Nat Rev Genet. 2004 Feb;5(2):101-13 18586725 - Bioinformatics. 2008 Jul 1;24(13):i277-85 24817581 - PLoS One. 2014;9(5):e95004 17827442 - Mol Interv. 2007 Aug;7(4):216-23 19339045 - Lancet. 2009 Apr 18;373(9672):1341-51 23925671 - Nat Prod Rep. 2013 Oct 11;30(10):1284-98 20883195 - Comb Chem High Throughput Screen. 2010 Dec;13(10):837-48 19639792 - Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(8):1018-21 23340113 - Drug Discov Today. 2013 May;18(9-10):495-501 17630928 - Curr Drug Discov Technol. 2007 Jun;4(1):48-58 |
| References_xml | – volume: 406 start-page: 378 year: 2000 end-page: 82 ident: CR11 article-title: Error and attack tolerance of complex networks publication-title: Nature doi: 10.1038/35019019 – volume: 28 start-page: 41 year: 2008 end-page: 3 ident: CR28 article-title: Intervention effect of Qishenyiqi dripping pills on early ventricular remodeling after acute myocardial infarction publication-title: Chin J Evid Based Cardiovasc Med – volume: 34 start-page: 1018 year: 2009 end-page: 21 ident: CR29 article-title: Analysis of myocardial proteomic alteration after Qishenyiqi formula treatment in acute infarcted rat hearts publication-title: Zhongguo Zhong Yao Za Zhi – volume: 13 start-page: 446 year: 2013 end-page: 51 ident: CR22 article-title: Intervention effects and safety of cardiovascular Polypill for the relevant risk factors of coronary heart disease: a systematic review publication-title: Chin J Evid-based Med – volume: 143 start-page: 105 year: 2010 end-page: 9 ident: CR30 article-title: QI-SHEN-YI-QI accelerates angiogenesis after myocardial infarction in rats publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2008.11.210 – volume: 4 start-page: 48 year: 2007 end-page: 58 ident: CR6 article-title: Targetability of human disease genes publication-title: Curr Drug Discov Technol doi: 10.2174/157016307781115494 – volume: 326 start-page: 1419 year: 2003 ident: CR23 article-title: A strategy to reduce cardiovascular disease by more than 80% publication-title: BMJ doi: 10.1136/bmj.326.7404.1419 – volume: 101 start-page: 15148 year: 2004 end-page: 53 ident: CR9 article-title: Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0404315101 – volume: 373 start-page: 1341 year: 2009 end-page: 51 ident: CR24 article-title: Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial publication-title: Lancet doi: 10.1016/S0140-6736(09)60611-5 – volume: 5 start-page: 101 year: 2004 end-page: 13 ident: CR12 article-title: Network biology: understanding the cell's functional organization publication-title: Nat Rev Genet doi: 10.1038/nrg1272 – volume: 82 start-page: 17 year: 2011 end-page: 33 ident: CR20 article-title: Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation-rationale, methods and preliminary results from a Sino-American collaboration publication-title: Fitoterapia doi: 10.1016/j.fitote.2010.11.017 – volume: 30 start-page: 1284 year: 2013 end-page: 98 ident: CR18 article-title: Matching the power of high throughput screening to the chemical diversity of natural products publication-title: Nat Prod Rep doi: 10.1039/c3np70052f – volume: 41 start-page: 59 year: 2007 end-page: 60 ident: CR27 article-title: Effects of Qishenyiqi Dripping pills on high sensitivity C reactive protein in experimental atherosclerosis rabbits publication-title: Shanghai J Traditi Chin Med – volume: 10 start-page: 139 year: 2005 end-page: 47 ident: CR2 article-title: Target-based drug discovery: is something wrong? publication-title: Drug Discov Today doi: 10.1016/S1359-6446(04)03316-1 – volume: 4 start-page: 682 year: 2008 end-page: 90 ident: CR14 article-title: Network pharmacology: the next paradigm in drug discovery publication-title: Nat Chem Biol doi: 10.1038/nchembio.118 – volume: 862 start-page: 196 year: 2008 end-page: 204 ident: CR19 article-title: A method for the production and characterization of fractionated libraries from Chinese herbal formulas publication-title: J Chromatogr B Analyt Technol Biomed Life Sci doi: 10.1016/j.jchromb.2007.12.004 – volume: 18 start-page: 495 year: 2013 end-page: 501 ident: CR1 article-title: Shifting from the single to the multitarget paradigm in drug discovery publication-title: Drug Discov Today doi: 10.1016/j.drudis.2013.01.008 – volume: 303 start-page: 1795 year: 2004 ident: CR4 article-title: Rethinking drug discovery publication-title: Science doi: 10.1126/science.303.5665.1795 – ident: CR25 – volume: 3 start-page: 258 year: 2005 end-page: 61 ident: CR3 article-title: Theories and Methods Used in the Research of Modern Chinese Medicine by Drug Combination publication-title: Chin J Nat Med – volume: 9 start-page: e95004 year: 2014 ident: CR31 article-title: A network pharmacology study of Chinese medicine QiShenYiQi to reveal its underlying multi-compound, multi-target, multi-pathway mode of action publication-title: PLoS One doi: 10.1371/journal.pone.0095004 – volume: 17 start-page: S16 year: 2012 end-page: 23 ident: CR5 article-title: Target discovery from data mining approaches publication-title: Drug Discov Today doi: 10.1016/j.drudis.2011.12.006 – volume: 13 start-page: 837 year: 2010 end-page: 48 ident: CR21 article-title: High-throughput screening for bioactive components from traditional Chinese medicine publication-title: Comb Chem High Throughput Screen doi: 10.2174/138620710793360257 – volume: 7 start-page: 216 year: 2007 end-page: 23 ident: CR15 article-title: Optimizing combination chemotherapy by controlling drug ratios publication-title: Mol Interv doi: 10.1124/mi.7.4.8 – volume: 9 start-page: 24 year: 2014 ident: CR32 article-title: Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology publication-title: Chin Med doi: 10.1186/1749-8546-9-24 – volume: 13 start-page: 443 year: 2008 end-page: 8 ident: CR17 article-title: The future of high-throughput screening publication-title: J Biomol Screen doi: 10.1177/1087057108319644 – volume: 357 start-page: 299 year: 2007 end-page: 300 ident: CR16 article-title: Rational design of cancer-drug combinations publication-title: N Engl J Med doi: 10.1056/NEJMcibr072593 – volume: 7 start-page: 354 year: 2006 ident: CR7 article-title: A combined approach to data mining of textual and structured data to identify cancer-related targets publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-7-354 – volume: 23 start-page: 295 year: 2007 end-page: 7 ident: CR26 article-title: Effect of Qishenyiqi dripping pills on histology of experimental atherosclerotic plaque publication-title: J Nanjing Univ Traditi Chin Med – volume: 24 start-page: i277 year: 2008 end-page: 85 ident: CR8 article-title: Identifying gene-disease associations using centrality on a literature mined gene-interaction network publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn182 – volume: 36 start-page: W399 year: 2008 end-page: 405 ident: CR10 article-title: PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn296 – volume: 26 start-page: 178 year: 2005 end-page: 82 ident: CR13 article-title: The efficiency of multi-target drugs: the network approach might help drug design publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2005.02.007 – volume: 326 start-page: 1419 year: 2003 ident: BFaps20158_CR23 publication-title: BMJ doi: 10.1136/bmj.326.7404.1419 – volume: 36 start-page: W399 year: 2008 ident: BFaps20158_CR10 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn296 – volume: 18 start-page: 495 year: 2013 ident: BFaps20158_CR1 publication-title: Drug Discov Today doi: 10.1016/j.drudis.2013.01.008 – volume: 9 start-page: 24 year: 2014 ident: BFaps20158_CR32 publication-title: Chin Med doi: 10.1186/1749-8546-9-24 – volume: 24 start-page: i277 year: 2008 ident: BFaps20158_CR8 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn182 – volume: 13 start-page: 446 year: 2013 ident: BFaps20158_CR22 publication-title: Chin J Evid-based Med – volume: 17 start-page: S16 year: 2012 ident: BFaps20158_CR5 publication-title: Drug Discov Today doi: 10.1016/j.drudis.2011.12.006 – volume: 4 start-page: 48 year: 2007 ident: BFaps20158_CR6 publication-title: Curr Drug Discov Technol doi: 10.2174/157016307781115494 – volume: 4 start-page: 682 year: 2008 ident: BFaps20158_CR14 publication-title: Nat Chem Biol doi: 10.1038/nchembio.118 – volume: 101 start-page: 15148 year: 2004 ident: BFaps20158_CR9 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0404315101 – volume: 373 start-page: 1341 year: 2009 ident: BFaps20158_CR24 publication-title: Lancet doi: 10.1016/S0140-6736(09)60611-5 – volume: 10 start-page: 139 year: 2005 ident: BFaps20158_CR2 publication-title: Drug Discov Today doi: 10.1016/S1359-6446(04)03316-1 – volume: 7 start-page: 354 year: 2006 ident: BFaps20158_CR7 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-7-354 – volume: 357 start-page: 299 year: 2007 ident: BFaps20158_CR16 publication-title: N Engl J Med doi: 10.1056/NEJMcibr072593 – volume: 28 start-page: 41 year: 2008 ident: BFaps20158_CR28 publication-title: Chin J Evid Based Cardiovasc Med – volume: 23 start-page: 295 year: 2007 ident: BFaps20158_CR26 publication-title: J Nanjing Univ Traditi Chin Med – volume: 143 start-page: 105 year: 2010 ident: BFaps20158_CR30 publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2008.11.210 – volume: 26 start-page: 178 year: 2005 ident: BFaps20158_CR13 publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2005.02.007 – volume: 82 start-page: 17 year: 2011 ident: BFaps20158_CR20 publication-title: Fitoterapia doi: 10.1016/j.fitote.2010.11.017 – volume: 7 start-page: 216 year: 2007 ident: BFaps20158_CR15 publication-title: Mol Interv doi: 10.1124/mi.7.4.8 – volume: 9 start-page: e95004 year: 2014 ident: BFaps20158_CR31 publication-title: PLoS One doi: 10.1371/journal.pone.0095004 – volume: 3 start-page: 258 year: 2005 ident: BFaps20158_CR3 publication-title: Chin J Nat Med – volume: 303 start-page: 1795 year: 2004 ident: BFaps20158_CR4 publication-title: Science doi: 10.1126/science.303.5665.1795 – volume: 5 start-page: 101 year: 2004 ident: BFaps20158_CR12 publication-title: Nat Rev Genet doi: 10.1038/nrg1272 – ident: BFaps20158_CR25 doi: 10.1155/2013/738391 – volume: 406 start-page: 378 year: 2000 ident: BFaps20158_CR11 publication-title: Nature doi: 10.1038/35019019 – volume: 13 start-page: 837 year: 2010 ident: BFaps20158_CR21 publication-title: Comb Chem High Throughput Screen doi: 10.2174/138620710793360257 – volume: 13 start-page: 443 year: 2008 ident: BFaps20158_CR17 publication-title: J Biomol Screen doi: 10.1177/1087057108319644 – volume: 30 start-page: 1284 year: 2013 ident: BFaps20158_CR18 publication-title: Nat Prod Rep doi: 10.1039/c3np70052f – volume: 34 start-page: 1018 year: 2009 ident: BFaps20158_CR29 publication-title: Zhongguo Zhong Yao Za Zhi – volume: 862 start-page: 196 year: 2008 ident: BFaps20158_CR19 publication-title: J Chromatogr B Analyt Technol Biomed Life Sci doi: 10.1016/j.jchromb.2007.12.004 – volume: 41 start-page: 59 year: 2007 ident: BFaps20158_CR27 publication-title: Shanghai J Traditi Chin Med – reference: 20883195 - Comb Chem High Throughput Screen. 2010 Dec;13(10):837-48 – reference: 14735121 - Nat Rev Genet. 2004 Feb;5(2):101-13 – reference: 15471992 - Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15148-53 – reference: 24817581 - PLoS One. 2014;9(5):e95004 – reference: 18936753 - Nat Chem Biol. 2008 Nov;4(11):682-90 – reference: 18487273 - Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W399-405 – reference: 21108995 - Fitoterapia. 2011 Jan;82(1):17-33 – reference: 18586725 - Bioinformatics. 2008 Jul 1;24(13):i277-85 – reference: 15718163 - Drug Discov Today. 2005 Jan 15;10(2):139-47 – reference: 19203810 - Int J Cardiol. 2010 Aug 6;143(1):105-9 – reference: 17827442 - Mol Interv. 2007 Aug;7(4):216-23 – reference: 16857057 - BMC Bioinformatics. 2006;7:354 – reference: 25342960 - Chin Med. 2014 Sep 16;9:24 – reference: 18182334 - J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):196-204 – reference: 18660458 - J Biomol Screen. 2008 Jul;13(6):443-8 – reference: 19639792 - Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(8):1018-21 – reference: 15808341 - Trends Pharmacol Sci. 2005 Apr;26(4):178-82 – reference: 22178890 - Drug Discov Today. 2012 Feb;17 Suppl:S16-23 – reference: 17634467 - N Engl J Med. 2007 Jul 19;357(3):299-300 – reference: 12829553 - BMJ. 2003 Jun 28;326(7404):1419 – reference: 17630928 - Curr Drug Discov Technol. 2007 Jun;4(1):48-58 – reference: 19339045 - Lancet. 2009 Apr 18;373(9672):1341-51 – reference: 23925671 - Nat Prod Rep. 2013 Oct 11;30(10):1284-98 – reference: 23935677 - Evid Based Complement Alternat Med. 2013;2013:738391 – reference: 23340113 - Drug Discov Today. 2013 May;18(9-10):495-501 – reference: 10935628 - Nature. 2000 Jul 27;406(6794):378-82 |
| SSID | ssj0032319 |
| Score | 2.4025688 |
| SecondaryResourceType | review_article |
| Snippet | Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug... |
| SourceID | pubmedcentral proquest pubmed crossref springer chongqing |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 654 |
| SubjectTerms | Biomedical and Life Sciences Biomedicine Computational Biology - methods Data Mining Databases, Factual Drug Combinations Drug Synergism Drugs, Chinese Herbal - adverse effects Drugs, Chinese Herbal - therapeutic use High-Throughput Screening Assays Humans Immunology Internal Medicine Medical Microbiology Medicine, Chinese Traditional - methods Molecular Targeted Therapy Patient Selection perspective Pharmacology/Toxicology Phenotype Systems Biology Systems Integration Treatment Outcome Vaccine 中医药 中药复方制剂 新药开发 治疗效果 相容性 组件 药效学 靶向药物 |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEBZteumlJH06SYugIVCImrUlj6VTKW1CKLTkkMDehCTLTaF4N9nNYf99ZuTHdrulV2uQZI2s-UYz_oaxo6BzCUE7MTG1Eqp2ILQylTAhNpWXxtepWsP3H3Bxrb5Ny2l_4bbo0yqHMzEd1PUs0B35aQ5URR6tJXya3wqqGkXR1b6ExmP2JFGX4X6upqPDJRG7EPzNoSI_ScuBnlTqUzcnru68_KiJVOFm1v68RVOxaZy2EOd24uRf0dNklM532bMeTfLPnfr32KPYPmfHlx0d9eqEX63_rlqc8GN-uSaqXr1gX8-IPwIF6UWJm7PmKSV92WXMrjgC2vRk1mKrIINXcyq4HReRD0H5l-z6_Ozqy4XoqyqIgK7wUuROyYAgIkCjNORAHGXgchcb1YQAzoM3roh-EmvjSql0gy5PQwFVdK5C4eUrttPiuG8Yl9JA9OjgqTIqKcFPTBNUWccKrT56vhk7GJfWzjv2DAtAHamiyNiHYbFt6AnJqS7Gb5sC41JbVJIlJVmdsfej7NDRv6QOB53Z_lNc2PXGydjrTn1jF0WpQSFGzVi1odhRgMi3N1vaXzeJhFuVRuUaX_Fo2AJ_DLk1s_3_z-yAPSW5LgXtkO0s7-7jWwQ7S_8u7egHNFf_Gg priority: 102 providerName: ProQuest |
| Title | Efficacy-oriented compatibility for component-based Chinese medicine |
| URI | http://lib.cqvip.com/qk/95561A/201506/665287422.html https://link.springer.com/article/10.1038/aps.2015.8 https://www.ncbi.nlm.nih.gov/pubmed/25864650 https://www.proquest.com/docview/1685178466 https://pubmed.ncbi.nlm.nih.gov/PMC4594187 |
| Volume | 36 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3da9swED_68bC9jHWfbrsgWCkMqi6O5LP0UEa3pZRBSxgN5E3IstwNivuRFJb_vic7cpele7UOna07c7_jTr8D2HMqFeiU5X1dSi5Li1xJnXPtfJUXQhdlM63h7BxPx_LHJJusQZzfuTjA6ZOpXZgnNb67OvxzO_9CP_xRe2VcfbY3gXc7zQ7VOmxSRMKQhJ3JrpogCMPoSE26JB-ogDOFEsO1-2eksr68pYixHKNWgOdq_-Q_RdQmNp28hBcLUMmOWy_YgjVfv4L9UctKPT9gF4-XrKYHbJ-NHvmq56_h-zDQSJAgvw6kxwRBWdOZPmsbZ-eMcG3z5LqmVR7iXsnC3G0_9SzW5t_A-GR48e2UL4YrcEcZ8YynVgpHWMJhJRWmGKjK0KbWV7JyDm2BhbYDX_R9qW0mpKoo86lCXZVyLDcoxFvYqEnve2BCaPQF5Xky81IILPq6cjIrfU7BnxLgBHa6ozU3LYmGQQwbycEggU_xsI1b8JKH8RhXpqmPC2XIXibYy6gEPnaycaOnpHajzUx0KJMiYcuc0BYm8K41X7dF9IEE8iXDdgKBg3t5pf79q-HilpmWqaJP3Isu8JfKlTfb_q_qHXgeRNomtF3YmN3d-w8Ed2ZFD9bzSd6Dza_D89HPXuPZD54MAZQ |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwED6N7gFeEL_JNsASYxLSwprYcZwHhIB16thWVaiT9mZix2FIU9rRItR_ir-RuyRuKUW87TV2bMd39n0Xn78D2LUq4tKqPOxmhQhFkctQiSwNM-vK1PDMFHW2hrOB7J-LTxfJxQb88ndhKKzS74n1Rl2MLf0jP4gkZZFHaynfTa5DyhpFp6s-hUajFidu_hNdtunb40OU76s4PuqNPvbDNqtAaNEVnIVRLrhFI2plKZSMJHF0yTzKXSlKa2VupMny2JmuK7I84UKVCPlLOlBE58LGhmO7t2BT0I3WDmx-6A2Gn_3ezxEtEeCOZEqemeKeEJWrg3xC7OBR8kYRjcPluPp6jcZp1RyuYdz1UM2_zmtrM3h0D-62-JW9bxTuPmy46gHsDRsC7Pk-Gy3vc0332R4bLqmx5w_hsEeMFViRppbYQAtWB8HPmhjdOUMIXT8ZV1gakoktGKX4dlPHfBjAIzi_kRl_DJ0K-30KjPNMOoMupUic4FyablZakRQuRZyBvnYA24up1ZOGr0NLSQ2JOA7gtZ9sbVsKdMrEcaXro3iuNApJk5C0CuDloq5v6F-1drzMdLv4p3qpqgE8acS3aCJOlBSIigNIVwS7qEB036sl1bfLmvZbJJmIFH7irleBP7pcG9nW_0f2Am73R2en-vR4cLINd-idJgBuBzqz7z_cM4RaM_O81W8GX256Sf0GCD89Mg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NISFeEOMz7ANLjElIy9rEjmM_IDTRVRuDqQ-b1DcTOw5DQmlHi1D_Nf467vJVShFve40d2_Gdfb-Lz78D2Hcq4tKpLOzrXIQiz2SohE5D7XyRWq5tXmVr-HQhT6_Eh3Ey3oBf7V0YCqts98Rqo84njv6R9yJJWeTRWspe0YRFjAbDd9ObkDJI0Ulrm06jVpFzv_iJ7tvs7dkAZf06jocnl-9PwybDQOjQLZyHUSa4Q4PqZCGUjCTxdcksynwhCudkZqXVWext3-c6S7hQBcL_gg4X0dFwseXY7h24m3JEVbiW0nHn7HHETQS9I5mSj6Z4S43KVS-bEk94lBwpInS4npRfbtBMrRrGNbS7HrT518ltZRCHD-FBg2TZca16W7Dhy0dwMKqpsBeH7HJ5s2t2yA7YaEmSvXgMgxPirsCKNLHEC5qzKhx-XkfrLhiC6erJpMTSkIxtzijZt5951gYEPIGrW5nvp7BZYr_PgXGupbfoXIrEC86l7evCiST3KSIO9LoD2O6m1kxr5g4jJTUk4jiAN-1kG9eQoVNOjm-mOpTnyqCQDAnJqABedXXbhv5Va6eVmWm2gZlZKm0Az2rxdU3EiZIC8XEA6YpguwpE_L1aUn69rgjARaJFpPAT91sV-KPLtZG9-P_IXsI9XEjm49nF-Tbcp1fqSLgd2Jx__-F3EXPN7V6l3Aw-3_Zq-g0hez_5 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy-oriented+compatibility+for+component-based+Chinese+medicine&rft.jtitle=Acta+pharmacologica+Sinica&rft.au=Zhang%2C+Jun-hua&rft.au=Zhu%2C+Yan&rft.au=Fan%2C+Xiao-hui&rft.au=Zhang%2C+Bo-li&rft.date=2015-06-01&rft.eissn=1745-7254&rft.volume=36&rft.issue=6&rft.spage=654&rft_id=info:doi/10.1038%2Faps.2015.8&rft_id=info%3Apmid%2F25864650&rft.externalDocID=25864650 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F95561A%2F95561A.jpg |