Comparative effects of six probiotic strains on immune function in vitro

• Published in: British journal of nutrition Vol. 108; no. 3; pp. 459 - 470
• Main Authors: Dong, Honglin, Rowland, Ian, Yaqoob, Parveen
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.08.2012
• Subjects: Bifidobacterium - physiology; Bifidobacterium longum; Biological and medical sciences; Biomarkers; CD4-positive T-lymphocytes; Cells, Cultured; Cellular biology; chemokine CCL2; Cytokines - genetics; Cytokines - metabolism; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - immunology; granulocyte-macrophage colony-stimulating factor; Humans; Immune response; Immunology; immunomodulators; interferon-gamma; interleukin-10; interleukin-12; interleukin-1beta; interleukin-2; interleukin-4; interleukin-5; interleukin-6; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Killer Cells, Natural - microbiology; Lactobacillus - physiology; Lactobacillus casei; Lactobacillus reuteri; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - microbiology; Lymphocyte Activation; Lymphocytes; lymphotoxin; macrophage colony-stimulating factor; natural killer cells; Nutritional Immunology; Probiotics; Probiotics - metabolism; tumor necrosis factor-alpha; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Probiotics; Immune function; Cytokines; Lymphocytes; Probiotic; Vertebrata; Mammalia; Cytokine; Probiotics: Lymphocytes; In vitro; Lymphocyte

There is considerable interest in the strain specificity of immune modulation by probiotics. The present study compared the immunomodulatory properties of six probiotic strains of different species and two genera in a human peripheral blood mononuclear cell (PBMC) model in vitro. Live cells of lacto...