Association of epilepsy, anti-epileptic drugs (AEDs), and type 2 diabetes mellitus (T2DM): a population-based cohort retrospective study, impact of AEDs on T2DM-related molecular pathway, and via peroxisome proliferator-activated receptor γ transactivation

• Published in: Frontiers in endocrinology (Lausanne) Vol. 14; p. 1156952
• Main Authors: Tien, Ni, Wu, Tien-Yuan, Lin, Cheng-Li, Chu, Fang-Yi, Wang, Charles C. N., Hsu, Chung Y., Tsai, Fuu-Jen, Fang, Yi-Jen, Lim, Yun-Ping
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.06.2023
• Subjects: anti-epileptic drugs; Anticonvulsants - adverse effects; Cohort Studies; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - epidemiology; Endocrinology; epilepsy; Epilepsy - complications; Epilepsy - drug therapy; Epilepsy - epidemiology; Humans; next-generation RNA sequencing; peroxisome proliferator-activated receptor γ; PPAR gamma - genetics; Retrospective Studies; Transcriptional Activation; type 2 diabetes mellitus; epilepsy; type 2 diabetes mellitus; anti-epileptic drugs; next-generation RNA sequencing; peroxisome proliferator-activated receptor γ
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2023.1156952

A potential association between epilepsy and subsequent type 2 diabetes mellitus (T2DM) has emerged in recent studies. However, the association between epilepsy, anti-epileptic drugs (AEDs), and the risk of T2DM development remains controversial. We aimed to conduct a nationwide, population-based, r...