Immunological characterization and comparison of children with COVID-19 from their adult counterparts at single-cell resolution

• Published in: Frontiers in immunology Vol. 15; p. 1358725
• Main Authors: Jia, Ran, Li, Zifeng, Hu, Shiwen, Chang, Hailing, Zeng, Mei, Liu, Pengcheng, Lu, Lijuan, Xu, Menghua, Zhai, Xiaowen, Qian, Maoxiang, Xu, Jin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.08.2024
• Subjects: Adaptive Immunity; Adolescent; Adult; Cellular Senescence - immunology; Child; Child, Preschool; children; COVID-19; COVID-19 - immunology; Cytotoxicity, Immunologic; Female; Humans; Immunology; innate immunity; Interferon Type I - immunology; Killer Cells, Natural - immunology; Male; Middle Aged; Monocytes - immunology; Monocytes - metabolism; NK cell; SARS-CoV-2 - immunology; Single-Cell Analysis; single-cell RNA sequencing; Young Adult; COVID-19; single-cell RNA sequencing; innate immunity; children; NK cell

The immunological characteristics that could protect children with coronavirus disease 2019 (COVID-19) from severe or fatal illnesses have not been fully understood yet. Here, we performed single-cell RNA sequencing (scRNA-seq) analysis on peripheral blood samples of 15 children (8 with COVID-19) an...