ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism

• Published in: Immunity (Cambridge, Mass.) Vol. 41; no. 5; pp. 789 - 801
• Main Authors: Proietti, Michele, Cornacchione, Vanessa, Rezzonico Jost, Tanja, Romagnani, Andrea, Faliti, Caterina Elisa, Perruzza, Lisa, Rigoni, Rosita, Radaelli, Enrico, Caprioli, Flavio, Preziuso, Silvia, Brannetti, Barbara, Thelen, Marcus, McCoy, Kathy D., Slack, Emma, Traggiai, Elisabetta, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2014; Elsevier Limited
• Subjects: Adenosine Triphosphate - metabolism; Age; Animals; Apoptosis; B-Lymphocytes - immunology; Bacteremia - immunology; Biomedical research; Experiments; Flow cytometry; Genetic Predisposition to Disease; Germinal Center - immunology; Humans; Immune system; Immunoglobulin A - immunology; Immunoglobulin M - blood; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Lymphocyte Depletion; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota - immunology; Mothers; Peyer's Patches - cytology; Peyer's Patches - immunology; Physiology; Receptors, Purinergic P2X7 - genetics; Receptors, Purinergic P2X7 - immunology; Rodents; Sepsis - immunology; Sepsis - microbiology; Symbiosis - immunology; T-Lymphocytes, Helper-Inducer - immunology

Microbial colonization of the gut induces the development of gut-associated lymphoid tissue (GALT). The molecular mechanisms that regulate GALT function and result in gut-commensal homeostasis are poorly defined. T follicular helper (Tfh) cells in Peyer’s patches (PPs) promote high-affinity IgA resp...