Role of Efflux Pumps in Reduced Susceptibility to Tigecycline among Clinical Isolates of Acinetobacter baumannii
Abstract Background: Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the last resort drug for treatment of multidrug-resistant A. baumannii infections. However,...
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| Published in | International journal of applied and basic medical research Vol. 12; no. 4; pp. 243 - 248 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Medknow Publications & Media Pvt Ltd
01.10.2022
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer - Medknow |
| Edition | 2 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2229-516X 2248-9606 |
| DOI | 10.4103/ijabmr.ijabmr_219_22 |
Cover
| Abstract | Abstract
Background:
Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the last resort drug for treatment of multidrug-resistant A. baumannii infections. However, non-susceptibility to this drug is a rising problem. Resistance to tigecycline is mediated by Resistance-nodulation-cell division (RND) efflux pumps.
Objective:
This study was done to detect efflux pump genes (adeABC) and regulator genes (adeS,adeR) responsible for tigecycline resistance among the clinical isolates of A. baumannii.
Materials and Methods:
A total of 150 OXA-51 confirmed clinical isolates were subjected for tigecycline susceptibility test by broth microdilution (BMD) method. All isolates irrespective of their MIC were subjected to conventional PCR for detection of efflux genes (adeABC) and regulator genes (adeRS).
Results:
Prevalence of tigecycline resistance was found to be 14 (9.33%) by the reference broth microdilution method (BMD). Overall prevalence of efflux genes was highest for adeB (69%) and lowest for adeR (29%). Combination of genes especially three, four or five were found more prevalent among resistant isolates with higher minimum inhibitory concentration (MIC).
Conclusion:
Combination of efflux genes confer higher MIC and can be a major contributor for resistance to tigecycline. |
|---|---|
| AbstractList | (
) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the last resort drug for treatment of multidrug-resistant
infections. However, non-susceptibility to this drug is a rising problem. Resistance to tigecycline is mediated by Resistance-nodulation-cell division (RND) efflux pumps.
This study was done to detect efflux pump genes (adeABC) and regulator genes (adeS,adeR) responsible for tigecycline resistance among the clinical isolates of
.
A total of 150 OXA-51 confirmed clinical isolates were subjected for tigecycline susceptibility test by broth microdilution (BMD) method. All isolates irrespective of their MIC were subjected to conventional PCR for detection of efflux genes (adeABC) and regulator genes (adeRS).
Prevalence of tigecycline resistance was found to be 14 (9.33%) by the reference broth microdilution method (BMD). Overall prevalence of efflux genes was highest for adeB (69%) and lowest for adeR (29%). Combination of genes especially three, four or five were found more prevalent among resistant isolates with higher minimum inhibitory concentration (MIC).
Combination of efflux genes confer higher MIC and can be a major contributor for resistance to tigecycline. Abstract Background: Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the last resort drug for treatment of multidrug-resistant A. baumannii infections. However, non-susceptibility to this drug is a rising problem. Resistance to tigecycline is mediated by Resistance-nodulation-cell division (RND) efflux pumps. Objective: This study was done to detect efflux pump genes (adeABC) and regulator genes (adeS,adeR) responsible for tigecycline resistance among the clinical isolates of A. baumannii. Materials and Methods: A total of 150 OXA-51 confirmed clinical isolates were subjected for tigecycline susceptibility test by broth microdilution (BMD) method. All isolates irrespective of their MIC were subjected to conventional PCR for detection of efflux genes (adeABC) and regulator genes (adeRS). Results: Prevalence of tigecycline resistance was found to be 14 (9.33%) by the reference broth microdilution method (BMD). Overall prevalence of efflux genes was highest for adeB (69%) and lowest for adeR (29%). Combination of genes especially three, four or five were found more prevalent among resistant isolates with higher minimum inhibitory concentration (MIC). Conclusion: Combination of efflux genes confer higher MIC and can be a major contributor for resistance to tigecycline. Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the last resort drug for treatment of multidrug-resistant A. baumannii infections. However, non-susceptibility to this drug is a rising problem. Resistance to tigecycline is mediated by Resistance-nodulation-cell division (RND) efflux pumps.BackgroundAcinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the last resort drug for treatment of multidrug-resistant A. baumannii infections. However, non-susceptibility to this drug is a rising problem. Resistance to tigecycline is mediated by Resistance-nodulation-cell division (RND) efflux pumps.This study was done to detect efflux pump genes (adeABC) and regulator genes (adeS,adeR) responsible for tigecycline resistance among the clinical isolates of A. baumannii.ObjectiveThis study was done to detect efflux pump genes (adeABC) and regulator genes (adeS,adeR) responsible for tigecycline resistance among the clinical isolates of A. baumannii.A total of 150 OXA-51 confirmed clinical isolates were subjected for tigecycline susceptibility test by broth microdilution (BMD) method. All isolates irrespective of their MIC were subjected to conventional PCR for detection of efflux genes (adeABC) and regulator genes (adeRS).Materials and MethodsA total of 150 OXA-51 confirmed clinical isolates were subjected for tigecycline susceptibility test by broth microdilution (BMD) method. All isolates irrespective of their MIC were subjected to conventional PCR for detection of efflux genes (adeABC) and regulator genes (adeRS).Prevalence of tigecycline resistance was found to be 14 (9.33%) by the reference broth microdilution method (BMD). Overall prevalence of efflux genes was highest for adeB (69%) and lowest for adeR (29%). Combination of genes especially three, four or five were found more prevalent among resistant isolates with higher minimum inhibitory concentration (MIC).ResultsPrevalence of tigecycline resistance was found to be 14 (9.33%) by the reference broth microdilution method (BMD). Overall prevalence of efflux genes was highest for adeB (69%) and lowest for adeR (29%). Combination of genes especially three, four or five were found more prevalent among resistant isolates with higher minimum inhibitory concentration (MIC).Combination of efflux genes confer higher MIC and can be a major contributor for resistance to tigecycline.ConclusionCombination of efflux genes confer higher MIC and can be a major contributor for resistance to tigecycline. AbstractBackground:Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the last resort drug for treatment of multidrug-resistant A. baumannii infections. However, non-susceptibility to this drug is a rising problem. Resistance to tigecycline is mediated by Resistance-nodulation-cell division (RND) efflux pumps.Objective:This study was done to detect efflux pump genes (adeABC) and regulator genes (adeS,adeR) responsible for tigecycline resistance among the clinical isolates of A. baumannii.Materials and Methods:A total of 150 OXA-51 confirmed clinical isolates were subjected for tigecycline susceptibility test by broth microdilution (BMD) method. All isolates irrespective of their MIC were subjected to conventional PCR for detection of efflux genes (adeABC) and regulator genes (adeRS).Results:Prevalence of tigecycline resistance was found to be 14 (9.33%) by the reference broth microdilution method (BMD). Overall prevalence of efflux genes was highest for adeB (69%) and lowest for adeR (29%). Combination of genes especially three, four or five were found more prevalent among resistant isolates with higher minimum inhibitory concentration (MIC).Conclusion:Combination of efflux genes confer higher MIC and can be a major contributor for resistance to tigecycline. |
| Audience | Academic |
| Author | Pati, Amresh Mahapatra, Ashoka Gupta, Kavita |
| AuthorAffiliation | Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India |
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| Cites_doi | 10.4103/0366-6999.201601 10.1128/CMR.00058-07 10.4103/JLP.JLP_72_18 10.1099/ijsem.0.001318 10.1007/s10096-014-2179-7 10.4103/ijmm.IJMM_19_207 10.1128/AAC.45.12.3375-3380.2001 10.1111/j.1469-0691.2006.01456.x 10.1128/JCM.01021-06 10.3855/jidc.11410 10.1093/jac/dkm058 10.4103/0976-9668.149116 10.18869/modares.iem.2.4.8 10.4103/0975-7406.142949 10.1159/000335599 10.1128/AAC.01198-06 10.1016/j.nmni.2019.100549 10.17795/ajcmi-40898 10.1016/j.ijantimicag.2008.06.027 10.1016/j.jgar.2017.05.026 10.1007/s10096-020-04123-z 10.1016/j.ijmmb.2021.03.005 10.1093/jac/dkq218 10.1186/s12906-020-02887-7 |
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| Keywords | efflux pump Acinetobacter baumannii tigecycline resistance |
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| References | Yaghoubi (R4-20240902) 2021; 5 Ranjbar (R27-20240902) 2020; 49 Xu (R18-20240902) 2019; 30 Sun (R20-20240902) 2014; 33 Lin (R9-20240902) 2009; 33 Ruzin (R25-20240902) 2007; 59 Muhtarova (R23-20240902) 2017; 10 Hornsey (R6-20240902) 2010; 65 Gupta (R7-20240902) 2015; 6 Shankar (R10-20240902) 2019; 37 Angoti (R16-20240902) 2016; 2 Poirel (R2-20240902) 2006; 12 Nogbou (R19-20240902) 2021; 39 Yin (R13-20240902) 2021; 40 Kumari (R14-20240902) 2019; 11 Magnet (R24-20240902) 2001; 45 Hou (R26-20240902) 2012; 58 Turton (R8-20240902) 2006; 44 Gao (R11-20240902) 2017; 130 Peleg (R5-20240902) 2007; 51 Khurshid (R21-20240902) 2019; 13 Cosgaya (R3-20240902) 2016; 66 Mahmoudi (R15-20240902) 2020; 20 Beheshti (R22-20240902) 2014; 6 Singh (R12-20240902) 2013; 7 Peleg (R1-20240902) 2008; 21 Jassim (R17-20240902) 2016; 3 |
| References_xml | – volume: 130 start-page: 659 year: 2017 ident: R11-20240902 article-title: Trends in drug resistance of Acinetobacter baumannii over a 10-year period:Nationwide data from the China surveillance of antimicrobial resistance program publication-title: Chin Med J (Engl) doi: 10.4103/0366-6999.201601 – volume: 21 start-page: 538 year: 2008 ident: R1-20240902 article-title: Acinetobacter baumannii:Emergence of a successful pathogen publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00058-07 – volume: 11 start-page: 34 year: 2019 ident: R14-20240902 article-title: A 5-year surveillance on antimicrobial resistance of Acinetobacter isolates at a level-I trauma Centre of India publication-title: J Lab Physicians doi: 10.4103/JLP.JLP_72_18 – volume: 66 start-page: 4105 year: 2016 ident: R3-20240902 article-title: Acinetobacter dijkshoorniae sp. Nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex mainly recovered from clinical samples in different countries publication-title: Int J Syst Evol Microbiol doi: 10.1099/ijsem.0.001318 – volume: 33 start-page: 2141 year: 2014 ident: R20-20240902 article-title: AdeRS combination codes differentiate the response to efflux pump inhibitors in tigecycline-resistant isolates of extensively drug-resistant Acinetobacter baumannii publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-014-2179-7 – volume: 5 start-page: 1 year: 2021 ident: R4-20240902 article-title: Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance:Narrative review publication-title: Eur J Clin Microbiol Infect Dis – volume: 37 start-page: 91 year: 2019 ident: R10-20240902 article-title: Bad bug, no test:Tigecycline susceptibility testing challenges and way forward publication-title: Indian J Med Microbiol doi: 10.4103/ijmm.IJMM_19_207 – volume: 7 start-page: 2602 year: 2013 ident: R12-20240902 article-title: Acinetobacter baumannii:A brief account of mechanisms of multidrug resistance and current and future therapeutic management publication-title: J Clin Diagn Res – volume: 45 start-page: 3375 year: 2001 ident: R24-20240902 article-title: Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.45.12.3375-3380.2001 – volume: 12 start-page: 826 year: 2006 ident: R2-20240902 article-title: Carbapenem resistance in Acinetobacter baumannii:Mechanisms and epidemiology publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2006.01456.x – volume: 44 start-page: 2974 year: 2006 ident: R8-20240902 article-title: Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species publication-title: J Clin Microbiol doi: 10.1128/JCM.01021-06 – volume: 13 start-page: 899 year: 2019 ident: R21-20240902 article-title: Molecular mechanisms of antibiotic co-resistance among carbapenem resistant Acinetobacter baumannii publication-title: J Infect Dev Ctries doi: 10.3855/jidc.11410 – volume: 59 start-page: 1001 year: 2007 ident: R25-20240902 article-title: AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkm058 – volume: 6 start-page: 159 year: 2015 ident: R7-20240902 article-title: Isolation and identification of Acinetobacter species with special reference to antibiotic resistance publication-title: J Nat Sci Biol Med doi: 10.4103/0976-9668.149116 – volume: 2 start-page: 8 year: 2016 ident: R16-20240902 article-title: Detection of efflux pump genes (adeA, adeB, adeC and abeM) in Acinetobacter baumannii isolated from hospitalize patients, North-west of Iran publication-title: Infect Epidemiol Med doi: 10.18869/modares.iem.2.4.8 – volume: 6 start-page: 229 year: 2014 ident: R22-20240902 article-title: Detection of AdeABC efflux pump genes in tetracycline-resistant Acinetobacter baumannii isolates from burn and ventilator-associated pneumonia patients publication-title: J Pharm Bioallied Sci doi: 10.4103/0975-7406.142949 – volume: 58 start-page: 152 year: 2012 ident: R26-20240902 article-title: Study of the correlation of imipenem resistance with efflux pumps AdeABC, AdeIJK, AdeDE and AbeM in clinical isolates of Acinetobacter baumannii publication-title: Chemotherapy doi: 10.1159/000335599 – volume: 51 start-page: 2065 year: 2007 ident: R5-20240902 article-title: Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01198-06 – volume: 30 start-page: 100549 year: 2019 ident: R18-20240902 article-title: adeABC efflux gene in Acinetobacter baumannii publication-title: New Microbes New Infect doi: 10.1016/j.nmni.2019.100549 – volume: 3 start-page: 40898 year: 2016 ident: R17-20240902 article-title: AdeABC efflux pump genes in multidrug resistant Acinetobacter baumannii isolates publication-title: Avicenna J Clin Microbiol Infect doi: 10.17795/ajcmi-40898 – volume: 33 start-page: 27 year: 2009 ident: R9-20240902 article-title: Distribution of the multidrug efflux pump genes, adeABC, adeDE and adeIJK, and class 1 integron genes in multiple-antimicrobial-resistant clinical isolates of Acinetobacter baumannii-Acinetobacter calcoaceticus complex publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2008.06.027 – volume: 10 start-page: 238 year: 2017 ident: R23-20240902 article-title: Distribution of macrolide resistance mechanisms in Bulgarian clinical isolates of Streptococcus pyogenes during the years of 2013-2016 publication-title: J Glob Antimicrob Resist doi: 10.1016/j.jgar.2017.05.026 – volume: 40 start-page: 1149 year: 2021 ident: R13-20240902 article-title: Performance of VITEK 2, E-test, Kirby-Bauer disk diffusion, and modified Kirby-Bauer disk diffusion compared to reference broth microdilution for testing tigecycline susceptibility of carbapenem-resistant K. pneumoniae and A. baumannii in a multicenter study in China publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-020-04123-z – volume: 39 start-page: 218 year: 2021 ident: R19-20240902 article-title: Investigating multi-drug resistant Acinetobacter baumannii isolates at a tertiary hospital in Pretoria, South Africa publication-title: Indian J Med Microbiol doi: 10.1016/j.ijmmb.2021.03.005 – volume: 49 start-page: 1539 year: 2020 ident: R27-20240902 article-title: High frequency of Adea, AdeB and AdeC genes among Acinetobacter baumannii isolates publication-title: Iran J Public Health – volume: 65 start-page: 1589 year: 2010 ident: R6-20240902 article-title: AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkq218 – volume: 20 start-page: 92 year: 2020 ident: R15-20240902 article-title: Detection of adeABC efllux Pump encoding genes and antimicrobial effect of Mentha longifolia and Menthol on MICs of imipenem and ciprofloxacin in clinical isolates of Acinetobacter baumannii publication-title: BMC Complement Med Ther doi: 10.1186/s12906-020-02887-7 |
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Background:
Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system... ( ) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care units (ICUs). Tigecycline is the... AbstractBackground:Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially... Acinetobacter baumannii (A. baumannii) is a very well-known emerging pathogen and has become a major burden on healthcare system especially in intensive care... |
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| SubjectTerms | Disease susceptibility Genes Original Original Article Tetracycline Tetracyclines |
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| Title | Role of Efflux Pumps in Reduced Susceptibility to Tigecycline among Clinical Isolates of Acinetobacter baumannii |
| URI | https://doi.org/10.4103/ijabmr.ijabmr_219_22 https://www.ncbi.nlm.nih.gov/pubmed/36726662 https://www.proquest.com/docview/3134088946 https://www.proquest.com/docview/2771940537 https://pubmed.ncbi.nlm.nih.gov/PMC9886155 |
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