A Highly Translatable Dual‐arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor‐bearing Brain Tissues

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 19; no. 11; pp. e2207278 - n/a
• Main Authors: Negron, Karina, Kwak, Gijung, Wang, Heng, Li, Haolin, Huang, Yi‐Ting, Chen, Shun‐Wen, Tyler, Betty, Eberhart, Charles G., Hanes, Justin, Suk, Jung Soo
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2023
• Subjects: Animals; Brain; brain extracellular space; Drug Carriers; drug delivery nanoparticles; extracellular matrix (ECM) modulation; Glycolic acid; Hydraulic pressure; infusate osmolality; Lactic Acid; local infusion; Nanoparticles; Nanotechnology; Neoplasms; Particle Size; Poloxamers; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Rats; Tumors; extracellular matrix (ECM) modulation; drug delivery nanoparticles; brain extracellular space; infusate osmolality; local infusion

Drug delivery nanoparticles (NPs) based entirely on materials generally recognized as safe that provide widespread parenchymal distribution following intracranial administration via convection‐enhanced delivery (CED) are introduced. Poly(lactic‐co‐glycolic acid) (PLGA) NPs are coated with various po...