Epstein‐Barr virus nuclear antigen 1 (EBNA1) protein induction of epithelial‐mesenchymal transition in nasopharyngeal carcinoma cells

• Published in: Cancer Vol. 120; no. 3; pp. 363 - 372
• Main Authors: Wang, Lu, Tian, Wen‐Dong, Xu, Xia, Nie, Biao, Lu, Juan, Liu, Xiong, Zhang, Bao, Dong, Qi, Sunwoo, John B., Li, Gang, Li, Xiang‐Ping
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley-Blackwell 01.02.2014
• Subjects: Biological and medical sciences; Carcinoma; Cell Line, Tumor; Cell migration; Cell Movement; Epithelial-Mesenchymal Transition; Epstein-Barr virus; Epstein-Barr Virus Nuclear Antigens - physiology; Homeodomain Proteins - physiology; Humans; Medical sciences; metastasis; microRNA; MicroRNAs - physiology; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - pathology; Neoplasm Invasiveness; Otorhinolaryngology. Stomatology; Signal Transduction; Transcription Factors - physiology; Transforming Growth Factor beta1 - physiology; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Zinc Finger E-box-Binding Homeobox 1; RNA interference; Nasopharynx cancer; Epstein Barr virus; Nasopharynx carcinoma; Metastasis; Cell transformation; Cancerology; ENT disease; Pharynx disease; Epstein-Barr virus; epithelial-mesenchymal transition; Cell; Gammaherpesvirinae; nasopharyngeal carcinoma; Induction; Herpesviridae; Micro RNA; Malignant tumor; Protein; Infection; Virus; Gene silencing; Viral disease; microRNA; Epithelial mesenchymal transition; Cancer; metastasis

BACKGROUND The Epstein‐Barr virus (EBV)‐encoded EB nuclear antigen 1 (EBNA1) protein is required for maintenance and transmission of the viral episome in EBV‐infected cells. The objective of this study was to investigate the role of EBNA1 protein in nasopharyngeal carcinoma (NPC). METHODS Tissue sam...