Th17 lymphocyte‐dependent degradation of joint cartilage by synovial fibroblasts in a humanized mouse model of arthritis and reversal by secukinumab - Margheri, Francesca; Maggi, Laura; Biagioni, Alessio; Chillà, Anastasia; Laurenzana, Anna; Bianchini, Francesca; Bani, Daniele; Capone, Manuela; Mazzoni, Alessio; Rossi, Maria Caterina; Liotta, Francesco; Cosmi, Lorenzo; et al. (European journal of immunology, 2021)
Keywords: Adolescent; Animal models; Animals; Antibodies, Monoclonal, Humanized - therapeutic use; Arthritis; Arthritis, Experimental - immunology; Arthritis, Experimental - pathology; Arthritis, Experimental - therapy; Arthritis, Juvenile - immunology; Arthritis, Juvenile - pathology; Arthritis, Juvenile - therapy; Cartilage; Cartilage (articular); Cartilage degradation; Cartilage, Articular - immunology; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Case-Control Studies; Child; Child, Preschool; Collagen; Cytokines; Cytokines - immunology; Degradation; Disease Models, Animal; Fibroblasts; Fibroblasts - immunology; Fibroblasts - metabolism; Fibroblasts - pathology; Gelatinase A; Gelatinase B; Helper cells; Humans; In Vitro Techniques; Interleukin-17 - antagonists & inhibitors; Juvenile idiopathic arthritis; Lymphocytes; Lymphocytes T; Mice; Mice, SCID; Monoclonal antibodies; Peripheral blood; Phenotypes; Proteolysis; Synovial fibroblasts; Synovial fluid; Synovial Membrane - immunology; Synovial Membrane - metabolism; Synovial Membrane - pathology; Th17 Cells - immunology; Th17 Cells - pathology; Thrombolytic drugs; T‐helper lymphocytes; U-Plasminogen activator; Synovial fibroblasts; Cartilage degradation; T-helper lymphocytes; Juvenile idiopathic arthritis