Exploratory behavior, learning ability, and thyroid hormonal responses to stress in female rats rehabilitating from postnatal hypothyroidism

• Published in: Developmental psychobiology Vol. 19; no. 6; p. 537
• Main Authors: Tamasy, V, Meisami, E, Du, J Z, Timiras, P S
• Format: Journal Article
• Language: English
• Published: United States 01.11.1986
• Subjects: Animals; Avoidance Learning - physiology; Body Weight; Conditioning, Classical - physiology; Exploratory Behavior - physiology; Extinction, Psychological - physiology; Female; Habituation, Psychophysiologic - physiology; Hypothyroidism - physiopathology; Learning - physiology; Propylthiouracil - pharmacology; Rats; Rats, Inbred Strains; Stress, Physiological - physiopathology; Thyrotropin - blood; Thyroxine - blood; Triiodothyronine - blood

Newborn female Long-Evans rats were divided into groups of normal, hypothyroid [0.1% propylthiouracil (PTU) a reversible antithyroid goitrogen in the litter's drinking water], and hypothyroid rehabilitated (PTU water from birth to day 25, normal water thereafter). The rats were tested for sever...