T Cell‐Mediated Transport of Polymer Nanoparticles across the Blood–Brain Barrier

• Published in: Advanced healthcare materials Vol. 10; no. 2; pp. e2001375 - n/a
• Main Authors: Ayer, Maxime, Schuster, Markus, Gruber, Isabelle, Blatti, Claudia, Kaba, Elisa, Enzmann, Gaby, Burri, Olivier, Guiet, Romain, Seitz, Arne, Engelhardt, Britta, Klok, Harm‐Anton
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.01.2021; John Wiley and Sons Inc
• Subjects: Animals; Biological Transport; Blood-Brain Barrier; blood–brain barriers; CD4 antigen; Cell culture; cell‐mediated deliveries; cell‐surface modifications; Central nervous system; Confocal microscopy; Drug delivery; Drug Delivery Systems; Immobilization; Immunological memory; Lymphocytes; Lymphocytes T; Memory cells; Mice; nanomedicines; Nanoparticles; Parenchyma; Polyethylene glycol; Polymers; Polystyrene; Polystyrene resins; T-Lymphocytes; blood-brain barriers; nanoparticles; cell-surface modifications; nanomedicines; cell-mediated deliveries

Delivery of therapeutics to the central nervous system (CNS) is challenging due to the presence of the blood–brain barrier (BBB). Amongst various approaches that have been explored to facilitate drug delivery to the CNS, the use of cells that have the intrinsic ability to cross the BBB is relatively...