Helicobacter pylori induce neutrophil transendothelial migration: Role of the bacterial HP-NAP

• Published in: FEMS microbiology letters Vol. 249; no. 1; pp. 95 - 103
• Main Authors: Brisslert, Mikael, Enarsson, Karin, Lundin, Samuel, Karlsson, Anna, Kusters, Johannes G., Svennerholm, Ann-Mari, Backert, Steffen, Quiding-Järbrink, Marianne
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier B.V 01.08.2005; Blackwell Publishing Ltd; Blackwell
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Proteins - pharmacology; Bacteriology; Biological and medical sciences; Cells, Cultured; Chemotactic Factors - genetics; Chemotactic Factors - metabolism; Chemotactic Factors - pharmacology; Chemotaxis, Leukocyte - drug effects; Endothelial cells; Endothelial Cells - immunology; Endothelium, Vascular - cytology; Endothelium, Vascular - immunology; Fundamental and applied biological sciences. Psychology; Genetics; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - immunology; Helicobacter pylori - metabolism; HP-NAP; Humans; Inflammation; Microbiology; Neutrophil Activation - immunology; Neutrophils - immunology; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Transmigration; HP-NAP; Transmigration; Inflammation; Helicobacter pylori; Endothelial cells; Endothelial cell; Statistical analysis; Spirillales; Spirillaceae; Protein; Gastritis; Mutagenesis; Bacteria; Neutrophil; Microaerophily

Continuous recruitment of neutrophils into the inflamed gastric mucosal tissue is a hallmark of Helicobacter pylori infection in humans. In this study, we examined the ability of H. pylori to induce transendothelial migration of neutrophils using a transwell system consisting of a cultured monolayer...