Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS‐CoV‐2 Replication Complex

• Published in: Chembiochem : a European journal of chemical biology Vol. 24; no. 8; pp. e202300095 - n/a
• Main Authors: Apostle, Alexander, Yin, Yipeng, Chillar, Komal, Eriyagama, Adikari M. D. N., Arneson, Reed, Burke, Emma, Fang, Shiyue, Yuan, Yinan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 17.04.2023
• Subjects: 5-Methylcytosine; Adenosine; Catalytic activity; COVID-19; Diabetes mellitus; epitranscriptomics; Genomes; Humans; N6-methyladenosine; Replication; Ribonucleic acid; RNA; RNA - genetics; RNA modification; RNA, Viral - genetics; RNA-dependent RNA polymerase; SARS-CoV-2; SARS-CoV-2 - genetics; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Viral diseases; COVID-19; RNA modification; SARS-CoV-2; RNA-dependent RNA polymerase; epitranscriptomics

SARS‐CoV‐2 causes individualized symptoms. Many reasons have been given. We propose that an individual's epitranscriptomic system could be responsible as well. The viral RNA genome can be subject to epitranscriptomic modifications, which can be different for different individuals, and thus epit...