The relationship between body mass index and outcomes in leukemic patients undergoing allogeneic hematopoietic stem cell transplantation

• Published in: Clinical transplantation Vol. 26; no. 1; pp. 149 - 155
• Main Authors: Hadjibabaie, Molouk, Tabeefar, Hamed, Alimoghaddam, Kamran, Iravani, Masood, Eslami, Kaveh, Honarmand, Hooshyar, Javadi, Mohammad reza, Khatami, Farnaz, Ashouri, Asieh, Ghavamzadeh, Ardeshir
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2012; Wiley
• Subjects: Adolescent; Adult; Biological and medical sciences; Body Mass Index; Child; Child, Preschool; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Survival; Graft vs Host Disease - etiology; Graft vs Host Disease - mortality; Hematologic and hematopoietic diseases; Hematologic Neoplasms - therapy; hematopoietic stem cell transplantation; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; leukemia patients; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Prognosis; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Rate; Tissue, organ and graft immunology; Transplantation Conditioning; Transplantation, Homologous; Young Adult; Human; leukemia patients; Prognosis; Stem cell; Leukemia; Hematopoietic cell; Homograft; Patient; Malignant hemopathy; Transplantation; Medicine; Body mass index; Treatment; Allogeneic hematopoietic stem cell transplantation; Surgery; Evolution; Hematopoietic stem cell transplantation; Cancer
• DOI: 10.1111/j.1399-0012.2011.01445.x
• ISSN: 0902-0063

Hadjibabaie M, Tabeefar H, Alimoghaddam K, Iravani M, Eslami K, Honarmand H, Javadi M, Khatami F, Ashouri A, Ghavamzadeh A. The relationship between body mass index and outcomes in leukemic patients undergoing allogeneic hematopoietic stem cell transplantation. 
Clin Transplant 2012: 26: 149–155. 
© 2011 John Wiley & Sons A/S. :  Hematopoietic stem cell transplantation (HSCT) is being used increasingly in an attempt to cure many hematological disorders. Obesity has become a world wide phenomenon and is a known risk factor for numerous medical conditions, but its role in transplant outcomes remained controversial. Total of 192 patients with acute leukemia who underwent sibling HLA matched HSCT were analyzed to find the effect of pre‐transplant body mass index (BMI) on transplant outcomes such as time to engraftment, infections, graft vs. host disease (GvHD), and overall survival (OS) for the period of three yr (April 2006–March 2009). There was a significant correlation between higher pre‐transplant BMI and shorter engraftment time (p = 0.010); but no relation between BMI and GvHD, infection, and OS was found. The results of this study showed that patients with higher BMI may have a shorter engraftment time; but lower, although not significant, survival rate compared to non‐obese patients.