DHE in the Pharmacotherapy of Migraine: Potential for a Larger Role

• Published in: Headache Vol. 46; no. s4; pp. S212 - S220
• Main Authors: Saper, Joel R., Silberstein, Stephen, Dodick, David, Rapoport, Alan
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.11.2006
• Subjects: Analgesics, Non-Narcotic - therapeutic use; central sensitization; cutaneous allodynia; Dihydroergotamine - therapeutic use; dihydroergotamine mesylate; Headache Disorders, Secondary - drug therapy; Headache Disorders, Secondary - epidemiology; headache prevalence; Humans; intranasal spray; medication overuse headache; menstrual migraine; migraine; Migraine Disorders - drug therapy; Migraine Disorders - epidemiology; migraine therapy; Prevalence

Despite a large array of currently marketed, frequently effective drugs for the acute treatment of migraine headache, comprising various classes and formulations, predictably reliable treatment for most headache types is often lacking. Dihydroergotamine mesylate (DHE) is a comparatively safe and eff...