Diffusivities of dichloromethane in poly(lactide-co-glycolide)
Diffusion of dichloromethane in poly(lactide-co-glycolide) (PLGA), the rate-limiting step in the later stages of drying of microparticles formed in common encapsulation processes, was studied by the step-change sorption technique in a dynamic vapor sorption apparatus. Methods were developed to creat...
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| Published in | Journal of applied polymer science Vol. 112; no. 3; pp. 1622 - 1629 |
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| Abstract | Diffusion of dichloromethane in poly(lactide-co-glycolide) (PLGA), the rate-limiting step in the later stages of drying of microparticles formed in common encapsulation processes, was studied by the step-change sorption technique in a dynamic vapor sorption apparatus. Methods were developed to create films of polymer with the appropriate thicknesses for accurate diffusion determination over a wide range of solvent composition. Mutual diffusivities were measured at 5, 25, and 35°C from 10 to 70 wt % solvent. Values range from 2 x 10⁻¹⁰ m²/s at high solvent compositions to as low as 1 x 10⁻¹³ m²/s at solvent compositions just above the glass transition of the mixture. Equilibrium sorption isotherms were measured in the same apparatus and agreed favorably with Flory-Huggins theory using a value of χ = 0.31. The glass transition temperatures of the system were measured over the range of 0-11 wt % solvent content by modulated differential scanning calorimetry. The composition dependence was fit to the Fox equation, which estimated values of the pure polymer and the solvent Tg to be 39.3 and -131°C, respectively. These values, along with the diffusivity data, were used to deduce the free-volume parameters specific to PLGA. |
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| AbstractList | Diffusion of dichloromethane in poly(lactide-co-glycolide) (PLGA), the rate-limiting step in the later stages of drying of microparticles formed in common encapsulation processes, was studied by the step-change sorption technique in a dynamic vapor sorption apparatus. Methods were developed to create films of polymer with the appropriate thicknesses for accurate diffusion determination over a wide range of solvent composition. Mutual diffusivities were measured at 5, 25, and 35 deg C from 10 to 70 wt % solvent. Values range from 2 X 10-10 m2/s at high solvent compositions to as low as 1 X 10-13 m2/s at solvent compositions just above the glass transition of the mixture. Equilibrium sorption isotherms were measured in the same apparatus and agreed favorably with Flory-Huggins theory using a value of = 0.31. The glass transition temperatures of the system were measured over the range of 0-11 wt % solvent content by modulated differential scanning calorimetry. The composition dependence was fit to the Fox equation, which estimated values of the pure polymer and the solvent Tg to be 39.3 and -131 deg C, respectively. These values, along with the diffusivity data, were used to deduce the free-volume parameters specific to PLGA. Abstract Diffusion of dichloromethane in poly(lactide‐ co ‐glycolide) (PLGA), the rate‐limiting step in the later stages of drying of microparticles formed in common encapsulation processes, was studied by the step‐change sorption technique in a dynamic vapor sorption apparatus. Methods were developed to create films of polymer with the appropriate thicknesses for accurate diffusion determination over a wide range of solvent composition. Mutual diffusivities were measured at 5, 25, and 35°C from 10 to 70 wt % solvent. Values range from 2 × 10 −10 m 2 /s at high solvent compositions to as low as 1 × 10 −13 m 2 /s at solvent compositions just above the glass transition of the mixture. Equilibrium sorption isotherms were measured in the same apparatus and agreed favorably with Flory‐Huggins theory using a value of χ = 0.31. The glass transition temperatures of the system were measured over the range of 0–11 wt % solvent content by modulated differential scanning calorimetry. The composition dependence was fit to the Fox equation, which estimated values of the pure polymer and the solvent T g to be 39.3 and −131°C, respectively. These values, along with the diffusivity data, were used to deduce the free‐volume parameters specific to PLGA. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 Diffusion of dichloromethane in poly(lactide-co-glycolide) (PLGA), the rate-limiting step in the later stages of drying of microparticles formed in common encapsulation processes, was studied by the step-change sorption technique in a dynamic vapor sorption apparatus. Methods were developed to create films of polymer with the appropriate thicknesses for accurate diffusion determination over a wide range of solvent composition. Mutual diffusivities were measured at 5, 25, and 35°C from 10 to 70 wt % solvent. Values range from 2 x 10⁻¹⁰ m²/s at high solvent compositions to as low as 1 x 10⁻¹³ m²/s at solvent compositions just above the glass transition of the mixture. Equilibrium sorption isotherms were measured in the same apparatus and agreed favorably with Flory-Huggins theory using a value of χ = 0.31. The glass transition temperatures of the system were measured over the range of 0-11 wt % solvent content by modulated differential scanning calorimetry. The composition dependence was fit to the Fox equation, which estimated values of the pure polymer and the solvent Tg to be 39.3 and -131°C, respectively. These values, along with the diffusivity data, were used to deduce the free-volume parameters specific to PLGA. Diffusion of dichloromethane in poly(lactide‐co‐glycolide) (PLGA), the rate‐limiting step in the later stages of drying of microparticles formed in common encapsulation processes, was studied by the step‐change sorption technique in a dynamic vapor sorption apparatus. Methods were developed to create films of polymer with the appropriate thicknesses for accurate diffusion determination over a wide range of solvent composition. Mutual diffusivities were measured at 5, 25, and 35°C from 10 to 70 wt % solvent. Values range from 2 × 10−10 m2/s at high solvent compositions to as low as 1 × 10−13 m2/s at solvent compositions just above the glass transition of the mixture. Equilibrium sorption isotherms were measured in the same apparatus and agreed favorably with Flory‐Huggins theory using a value of χ = 0.31. The glass transition temperatures of the system were measured over the range of 0–11 wt % solvent content by modulated differential scanning calorimetry. The composition dependence was fit to the Fox equation, which estimated values of the pure polymer and the solvent Tg to be 39.3 and −131°C, respectively. These values, along with the diffusivity data, were used to deduce the free‐volume parameters specific to PLGA. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 |
| Author | Anderl, Jeffrey N. Foss, Willard R. Clausi, Amber L. Burke, Paul A. |
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| CitedBy_id | crossref_primary_10_1016_j_ijpharm_2015_07_068 crossref_primary_10_1016_j_ijpharm_2010_08_016 crossref_primary_10_1002_app_41199 crossref_primary_10_1021_acs_langmuir_0c03311 |
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| Snippet | Diffusion of dichloromethane in poly(lactide-co-glycolide) (PLGA), the rate-limiting step in the later stages of drying of microparticles formed in common... Diffusion of dichloromethane in poly(lactide‐co‐glycolide) (PLGA), the rate‐limiting step in the later stages of drying of microparticles formed in common... Abstract Diffusion of dichloromethane in poly(lactide‐ co ‐glycolide) (PLGA), the rate‐limiting step in the later stages of drying of microparticles formed in... |
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| Title | Diffusivities of dichloromethane in poly(lactide-co-glycolide) |
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