Involvement of the γ Isoform of cPLA2 in the Biosynthesis of Bioactive N-Acylethanolamines

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 17; p. 5213
• Main Authors: Guo, Yiman, Uyama, Toru, Rahman, S. M. Khaledur, Sikder, Mohammad Mamun, Hussain, Zahir, Tsuboi, Kazuhito, Miyake, Minoru, Ueda, Natsuo
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 27.08.2021; MDPI
• Subjects: Acyltransferase; Analgesics; Anandamide; Biosynthesis; Cannabinoid receptors; Cannabinoids; Chromatography; endocannabinoid; Enzymes; Ethanolamine; Fatty acids; Glycerol; Inflammation; Isoforms; Lysophospholipase; Metabolism; N-Acylethanolamine; N-acyltransferase; Palmitylethanolamide; Phosphatidylethanolamine; Phospholipase; Phospholipase A1; Phospholipase A2; Proteins

Arachidonylethanolamide (anandamide) acts as an endogenous ligand of cannabinoid receptors, while other N-acylethanolamines (NAEs), such as palmitylethanolamide and oleylethanolamide, show analgesic, anti-inflammatory, and appetite-suppressing effects through other receptors. In mammalian tissues, N...