Characterization of alternative plasticizers in poly(vinyl chloride) sheets for blood containers

• Published in: Journal of vinyl & additive technology Vol. 22; no. 4; pp. 520 - 528
• Main Authors: Haishima, Yuji, Kawakami, Tsuyoshi, Fukui, Chie, Tanoue, Akito, Yuba, Toshiyasu, Ozono, Satoru, Kumada, Hidehumi, Inoue, Kaoru, Morikawa, Tomomi, Takahashi, Miwa, Fujisawa, Ayano, Yamasaki, Kayo, Nomura, Yusuke, Isama, Kazuo, Chung, Ung-il, Ogawa, Kumiko, Niimi, Shingo, Yoshida, Midori
• Format: Journal Article
• Language: English
• Published: Brookfield Blackwell Publishing Ltd 01.12.2016; John Wiley & Sons, Inc
• Subjects: Blood; Chlorides; Containers; Phthalates; Plasticizers; Polyvinyl chlorides; Sheets; Toxicity
• ISSN: 1083-5601; 1548-0585
• DOI: 10.1002/vnl.21472

This study aimed to optimize the ratio of dioctyl 4‐cyclohexene‐1,2‐dicarboxylate (DOTH) and di‐isononyl‐cyclohexane‐1,2‐dicarboxylate (DINCH®) for use as plasticizers in poly(vinyl chloride) (PVC) sheets. We also evaluated the biological safety of DOTH for its potential to be part of a safe PVC‐based blood container. The suppression of hemolysis in mannitol‐adenine‐phosphate / red cell concentrates (MAP/RCC) with DOTH/(DINCH®‐PVC) sheets and the elution of plasticizers from the sheets increased with higher DOTH compositions. The properties of the PVC sheet containing DOTH and DINCH® in the ratio of 25:33 parts against PVC 100 parts as a weight were almost identical to the PVC sheet made of di(2‐ethylhexyl) phthalate. From a subchronic toxicity test, DOTH did not show any adverse effects on all organs, including the testes, epididymis, liver, and kidneys. The no‐observed‐adverse‐effect level was 300 mg/kg body weight/day in a rat. These results suggest that DOTH/DINCH® (25:33) is a promising candidate for the replacement of di(2‐ethylhexyl) phthalate in blood containers. J. VINYL ADDIT. TECHNOL., 22:520–528, 2016. © 2015 Society of Plastics Engineers