Genomics‐Guided Efficient Identification of 2,5‐Diketopiperazine Derivatives from Actinobacteria

• Published in: Chembiochem : a European journal of chemical biology Vol. 24; no. 3; pp. e202200502 - n/a
• Main Authors: Liu, Jing, Li, Shu‐Ming
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.02.2023; John Wiley and Sons Inc
• Subjects: 2,5-DKPs; Actinobacteria - genetics; Actinobacteria - metabolism; Bioinformatics; Biological Products - metabolism; Biosynthetic Pathways - genetics; Computational Biology; Concept; Concepts; Diketopiperazines; dimeric DKPs; Fermentation; Gene clusters; Gene expression; genome mining; Genomes; Genomics; heterologous expression; Metabolites; Microorganisms; Multigene Family; Natural products; nucleobase-containing DKPs; Secondary metabolites; nucleobase-containing DKPs; heterologous expression; 2,5-DKPs; dimeric DKPs; genome mining

Secondary metabolites derived from microorganism constitute an important part of natural products. Mining of the microbial genomes revealed a large number of uncharacterized biosynthetic gene clusters, indicating their greater potential to synthetize specialized or secondary metabolites (SMs) than i...