Swelling‐Dependent Shape‐Based Transformation of a Human Mesenchymal Stromal Cells‐Laden 4D Bioprinted Construct for Cartilage Tissue Engineering

3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time‐dependent stimuli‐induced transformation, enables the fabrication of shape‐changing constructs. Here, a 4D biofa...

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Published inAdvanced healthcare materials Vol. 12; no. 2; pp. e2201891 - n/a
Main Authors Díaz‐Payno, Pedro J., Kalogeropoulou, Maria, Muntz, Iain, Kingma, Esther, Kops, Nicole, D'Este, Matteo, Koenderink, Gijsje H., Fratila‐Apachitei, Lidy E., Osch, Gerjo J. V. M., Zadpoor, Amir A.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.01.2023
John Wiley and Sons Inc
Subjects
3-D printers
4D bioprinting
Alginates
Alginates - chemistry
Alginic acid
biofabrication
Bioprinting
Bone marrow
Cartilage
Cell viability
Cellular structure
Flat surfaces
Histology
Humans
Hyaluronic Acid
Hydrogels
Inks
Mesenchymal Stem Cells
Mesenchyme
Multilayers
Printing, Three-Dimensional
Radius of curvature
Scaffolds
shape‐change
smart bioinks
Stromal cells
Swelling
Three dimensional printing
Time dependence
Tissue Engineering
Tissue Scaffolds - chemistry
Tyramine
tissue engineering
biofabrication
shape-change
smart bioinks
4D bioprinting
Online AccessGet full text
ISSN2192-2640
2192-2659
2192-2659
DOI10.1002/adhm.202201891

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Abstract 3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time‐dependent stimuli‐induced transformation, enables the fabrication of shape‐changing constructs. Here, a 4D biofabrication method is reported for cartilage engineering based on the differential swelling of a smart multi‐material system made from two hydrogel‐based materials: hyaluronan and alginate. Two ink formulations are used: tyramine‐functionalized hyaluronan (HAT, high‐swelling) and alginate with HAT (AHAT, low‐swelling). Both inks have similar elastic, shear‐thinning, and printability behavior. The inks are 3D printed into a bilayered scaffold before triggering the shape‐change by using liquid immersion as stimulus. In time (4D), the differential swelling between the two zones leads to the scaffold's self‐bending. Different designs are made to tune the radius of curvature and shape. A bioprinted formulation of AHAT and human bone marrow cells demonstrates high cell viability. After 28 days in chondrogenic medium, the curvature is clearly present while cartilage‐like matrix production is visible on histology. A proof‐of‐concept of the recently emerged technology of 4D bioprinting with a specific application for the design of curved structures potentially mimicking the curvature and multilayer cellular nature of native cartilage is demonstrated. 3D bioprinting poses serious limitations in the fabrication of multilayered curved constructs, motivating the development of 4D bioprinting as the next generation of biofabrication technologies. 4D bioprinting, combining 3D bioprinting with time‐dependent stimuli‐induced transformation, enables the fabrication of self‐bending constructs. Here, a 4D smart multi‐material system for curved cartilage engineering is reported as a proof‐of‐concept.
AbstractList 3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time‐dependent stimuli‐induced transformation, enables the fabrication of shape‐changing constructs. Here, a 4D biofabrication method is reported for cartilage engineering based on the differential swelling of a smart multi‐material system made from two hydrogel‐based materials: hyaluronan and alginate. Two ink formulations are used: tyramine‐functionalized hyaluronan (HAT, high‐swelling) and alginate with HAT (AHAT, low‐swelling). Both inks have similar elastic, shear‐thinning, and printability behavior. The inks are 3D printed into a bilayered scaffold before triggering the shape‐change by using liquid immersion as stimulus. In time (4D), the differential swelling between the two zones leads to the scaffold's self‐bending. Different designs are made to tune the radius of curvature and shape. A bioprinted formulation of AHAT and human bone marrow cells demonstrates high cell viability. After 28 days in chondrogenic medium, the curvature is clearly present while cartilage‐like matrix production is visible on histology. A proof‐of‐concept of the recently emerged technology of 4D bioprinting with a specific application for the design of curved structures potentially mimicking the curvature and multilayer cellular nature of native cartilage is demonstrated. 3D bioprinting poses serious limitations in the fabrication of multilayered curved constructs, motivating the development of 4D bioprinting as the next generation of biofabrication technologies. 4D bioprinting, combining 3D bioprinting with time‐dependent stimuli‐induced transformation, enables the fabrication of self‐bending constructs. Here, a 4D smart multi‐material system for curved cartilage engineering is reported as a proof‐of‐concept.
3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time‐dependent stimuli‐induced transformation, enables the fabrication of shape‐changing constructs. Here, a 4D biofabrication method is reported for cartilage engineering based on the differential swelling of a smart multi‐material system made from two hydrogel‐based materials: hyaluronan and alginate. Two ink formulations are used: tyramine‐functionalized hyaluronan (HAT, high‐swelling) and alginate with HAT (AHAT, low‐swelling). Both inks have similar elastic, shear‐thinning, and printability behavior. The inks are 3D printed into a bilayered scaffold before triggering the shape‐change by using liquid immersion as stimulus. In time (4D), the differential swelling between the two zones leads to the scaffold's self‐bending. Different designs are made to tune the radius of curvature and shape. A bioprinted formulation of AHAT and human bone marrow cells demonstrates high cell viability. After 28 days in chondrogenic medium, the curvature is clearly present while cartilage‐like matrix production is visible on histology. A proof‐of‐concept of the recently emerged technology of 4D bioprinting with a specific application for the design of curved structures potentially mimicking the curvature and multilayer cellular nature of native cartilage is demonstrated.
3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs. Here, a 4D biofabrication method is reported for cartilage engineering based on the differential swelling of a smart multi-material system made from two hydrogel-based materials: hyaluronan and alginate. Two ink formulations are used: tyramine-functionalized hyaluronan (HAT, high-swelling) and alginate with HAT (AHAT, low-swelling). Both inks have similar elastic, shear-thinning, and printability behavior. The inks are 3D printed into a bilayered scaffold before triggering the shape-change by using liquid immersion as stimulus. In time (4D), the differential swelling between the two zones leads to the scaffold's self-bending. Different designs are made to tune the radius of curvature and shape. A bioprinted formulation of AHAT and human bone marrow cells demonstrates high cell viability. After 28 days in chondrogenic medium, the curvature is clearly present while cartilage-like matrix production is visible on histology. A proof-of-concept of the recently emerged technology of 4D bioprinting with a specific application for the design of curved structures potentially mimicking the curvature and multilayer cellular nature of native cartilage is demonstrated.3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs. Here, a 4D biofabrication method is reported for cartilage engineering based on the differential swelling of a smart multi-material system made from two hydrogel-based materials: hyaluronan and alginate. Two ink formulations are used: tyramine-functionalized hyaluronan (HAT, high-swelling) and alginate with HAT (AHAT, low-swelling). Both inks have similar elastic, shear-thinning, and printability behavior. The inks are 3D printed into a bilayered scaffold before triggering the shape-change by using liquid immersion as stimulus. In time (4D), the differential swelling between the two zones leads to the scaffold's self-bending. Different designs are made to tune the radius of curvature and shape. A bioprinted formulation of AHAT and human bone marrow cells demonstrates high cell viability. After 28 days in chondrogenic medium, the curvature is clearly present while cartilage-like matrix production is visible on histology. A proof-of-concept of the recently emerged technology of 4D bioprinting with a specific application for the design of curved structures potentially mimicking the curvature and multilayer cellular nature of native cartilage is demonstrated.
Author Muntz, Iain
Osch, Gerjo J. V. M.
Kalogeropoulou, Maria
Díaz‐Payno, Pedro J.
Kops, Nicole
Kingma, Esther
D'Este, Matteo
Koenderink, Gijsje H.
Fratila‐Apachitei, Lidy E.
Zadpoor, Amir A.
AuthorAffiliation 1 Department of Biomechanical Engineering Faculty of Mechanical Maritime and Materials Engineering Delft University of Technology Delft 2628CD Netherlands
2 Department of Orthopedics and Sports Medicine Erasmus MC University Medical Center Rotterdam 3015GD Netherlands
5 Department of Otorhinolaryngology Erasmus MC University Medical Center Rotterdam 3015GD Netherlands
3 Department of Bionanoscience Kavli Institute of Nanoscience Delft Delft University of Technology Delft 2628CD Netherlands
4 AO Research Institute Davos Davos 7270 Switzerland
AuthorAffiliation_xml – name: 3 Department of Bionanoscience Kavli Institute of Nanoscience Delft Delft University of Technology Delft 2628CD Netherlands
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  orcidid: 0000-0003-1852-6409
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  orcidid: 0000-0003-3234-2112
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36308047$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1111/j.1525-1594.2010.01193.x
10.20473/j.djmkg.v52.i1.p36-40
10.1021/acs.chemrev.0c00008
10.3390/polym14020354
10.3390/su10082776
10.1088/1758-5090/aadf58
10.1016/j.biomaterials.2016.01.019
10.1073/pnas.1811296115
10.1088/1758-5090/8/1/013001
10.1371/journal.pone.0235052
10.1016/j.biomaterials.2003.09.046
10.1088/1758-5090/aacdc7
10.1038/s41467-017-00543-2
10.1002/biot.201000340
10.1016/j.actbio.2005.07.009
10.1039/C7MH00269F
10.1038/s41563-020-00803-5
10.1002/smll.202202196
10.1038/nrcardio.2016.170
10.1243/09544119JEIM288
10.1126/science.aav9051
10.1088/1758-5090/9/1/012001
10.1088/1758-5090/aa8dd8
10.1002/app.1992.070450211
10.1016/j.biomaterials.2020.120281
10.1063/1.5059393
10.1016/j.msec.2020.111701
10.1002/adbi.201700043
10.1088/1758-5090/aa8114
10.1016/j.mtbio.2020.100058
10.1007/s10856-006-0615-7
10.1007/s10439-016-1653-z
10.1021/acs.chemrev.0c00084
10.1021/acs.biomac.5b00188
10.1089/ten.tea.2019.0298
10.1088/1758-5090/ab6034
10.1002/adfm.202010104
10.1002/(SICI)1097-4636(199910)47:1<46::AID-JBM6>3.0.CO;2-N
10.1016/j.actbio.2021.04.016
10.1016/j.biomaterials.2013.09.078
10.1088/1758-5090/ab94cf
10.1021/acsbiomaterials.8b00416
10.1016/j.biomaterials.2012.01.007
10.1016/j.biomaterials.2018.09.044
10.1038/nmeth.2019
10.1126/sciadv.aba7406
10.1152/ajpcell.1996.271.3.C742
10.1039/C3TB21462A
10.1007/s10439-016-1704-5
10.1088/1758-5090/ab331e
10.1007/s40137-018-0198-5
10.1016/S0142-9612(01)00281-2
10.1007/BF01496959
10.1088/1758-5090/aa8cb7
10.1111/j.1525-1594.2005.00137.x
10.1002/term.1682
10.1038/s41598-021-84384-6
10.1088/1758-5090/ab5158
10.1088/1758-5090/ab39c5
10.1016/j.tibtech.2016.03.004
10.1038/s43246-021-00165-8
10.1021/acs.biomac.6b00366
10.1080/02652039109373974
10.1016/j.joca.2003.08.006
10.1080/09205063.2012.735100
10.3390/bioengineering7020032
10.7150/thno.50794
10.1002/adma.202109394
10.1007/978-1-0716-0989-7_2
10.3390/ijms17121976
10.1016/j.biomaterials.2011.08.027
10.1016/j.actbio.2022.03.009
10.3390/app11177821
10.1016/j.biomaterials.2009.06.034
10.1002/adma.201703443
10.1016/j.carbpol.2012.10.028
10.1016/j.biomaterials.2010.04.045
10.1016/j.biomaterials.2017.03.026
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Issue 2
Keywords tissue engineering
biofabrication
shape-change
smart bioinks
4D bioprinting
Language English
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2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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References 2017; 8
2017; 1
2021; 20
2017; 4
2019; 52
2020; 120
2019; 11
2013; 24
2021; 128
2004; 25
2007; 221
2017; 45
1999; 47
2020; 15
2021; 120
2020; 12
1929; 47
2005; 29
2017; 9
2019; 365
2016; 34
2003; 11
2020; 7
2018; 6
2020; 6
2021; 31
2014; 2
2018; 4
2022; 34
2016; 83
1992; 45
2021; 2221
2010; 31
2015; 16
2019; 6
2021; 2
2006; 17
2020; 260
2013; 92
2011; 32
2011; 35
2017; 29
2017; 131
2016; 17
2015; 9
2011; 6
2012; 33
1991; 8
2019; 188
2016; 13
2022; 143
2009; 30
2021; 11
2021
2002; 23
2018; 115
1996; 271
2022; 14
2020; 26
2014; 35
2005; 1
2018; 10
2016; 8
2016; 9
2022; 18
2012; 9
e_1_2_9_75_1
e_1_2_9_31_1
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e_1_2_9_50_1
e_1_2_9_73_1
e_1_2_9_10_1
e_1_2_9_35_1
e_1_2_9_56_1
e_1_2_9_77_1
e_1_2_9_12_1
e_1_2_9_33_1
e_1_2_9_54_1
Narcisi R. (e_1_2_9_79_1) 2021
e_1_2_9_71_1
e_1_2_9_14_1
e_1_2_9_39_1
e_1_2_9_16_1
e_1_2_9_37_1
e_1_2_9_58_1
e_1_2_9_18_1
e_1_2_9_41_1
e_1_2_9_64_1
e_1_2_9_20_1
e_1_2_9_22_1
e_1_2_9_68_1
e_1_2_9_24_1
e_1_2_9_43_1
e_1_2_9_66_1
e_1_2_9_8_1
e_1_2_9_6_1
e_1_2_9_4_1
e_1_2_9_60_1
e_1_2_9_2_1
e_1_2_9_26_1
e_1_2_9_49_1
e_1_2_9_28_1
e_1_2_9_47_1
e_1_2_9_30_1
e_1_2_9_53_1
e_1_2_9_74_1
e_1_2_9_51_1
e_1_2_9_72_1
e_1_2_9_11_1
e_1_2_9_34_1
e_1_2_9_57_1
e_1_2_9_78_1
e_1_2_9_13_1
e_1_2_9_32_1
e_1_2_9_55_1
e_1_2_9_76_1
e_1_2_9_70_1
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e_1_2_9_38_1
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e_1_2_9_36_1
e_1_2_9_59_1
e_1_2_9_19_1
e_1_2_9_42_1
e_1_2_9_63_1
e_1_2_9_40_1
Hendrijantini N. (e_1_2_9_45_1) 2019; 52
e_1_2_9_61_1
e_1_2_9_21_1
e_1_2_9_46_1
e_1_2_9_67_1
e_1_2_9_23_1
e_1_2_9_44_1
e_1_2_9_65_1
e_1_2_9_7_1
Manen T. (e_1_2_9_62_1) 2021
e_1_2_9_5_1
e_1_2_9_3_1
e_1_2_9_1_1
e_1_2_9_9_1
e_1_2_9_25_1
e_1_2_9_27_1
e_1_2_9_48_1
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References_xml – volume: 18
  year: 2022
  publication-title: Small
– volume: 14
  start-page: 354
  year: 2022
  publication-title: Polymers
– volume: 45
  start-page: 210
  year: 2017
  publication-title: Ann. Biomed. Eng.
– volume: 6
  year: 2019
  publication-title: Appl. Phys. Rev.
– volume: 29
  start-page: 838
  year: 2005
  publication-title: Artif. Organs
– volume: 8
  year: 2016
  publication-title: Biofabrication
– volume: 8
  start-page: 237
  year: 1991
  publication-title: Food Addit. Contam.
– volume: 31
  start-page: 6173
  year: 2010
  publication-title: Biomaterials
– year: 2021
– volume: 2221
  start-page: 15
  year: 2021
  end-page: 28
– volume: 6
  start-page: 4
  year: 2018
  publication-title: Curr. Surg. Rep.
– volume: 47
  start-page: 46
  year: 1999
  publication-title: J. Biomed. Mater. Res.
– volume: 4
  start-page: 3088
  year: 2018
  publication-title: ACS Biomater. Sci. Eng.
– volume: 33
  start-page: 3279
  year: 2012
  publication-title: Biomaterials
– volume: 271
  start-page: C742
  year: 1996
  publication-title: Am. J. Physiol.: Cell Physiol.
– volume: 34
  year: 2022
  publication-title: Adv. Mater.
– volume: 9
  start-page: 676
  year: 2012
  publication-title: Nat. Methods
– volume: 7
  start-page: 32
  year: 2020
  publication-title: Bioengineering
– volume: 2
  start-page: 56
  year: 2021
  publication-title: Commun. Mater.
– volume: 12
  year: 2020
  publication-title: Biofabrication
– volume: 120
  year: 2021
  publication-title: Mater. Sci. Eng., C
– volume: 35
  start-page: 741
  year: 2011
  publication-title: Artif. Organs
– volume: 9
  start-page: 1286
  year: 2015
  publication-title: J. Tissue Eng. Regener. Med.
– volume: 15
  year: 2020
  publication-title: PLoS One
– volume: 1
  start-page: 625
  year: 2005
  publication-title: Acta Biomater.
– volume: 10
  start-page: 2776
  year: 2018
  publication-title: Sustainability
– volume: 7
  year: 2020
  publication-title: Mater. Today Bio
– volume: 131
  start-page: 98
  year: 2017
  publication-title: Biomaterials
– volume: 143
  start-page: 266
  year: 2022
  publication-title: Acta Biomater.
– volume: 83
  start-page: 156
  year: 2016
  publication-title: Biomaterials
– volume: 11
  start-page: 879
  year: 2003
  publication-title: Osteoarthritis Cartilage
– volume: 11
  start-page: 7821
  year: 2021
  publication-title: Appl. Sci.
– volume: 13
  start-page: 701
  year: 2016
  publication-title: Nat. Rev. Cardiol.
– volume: 221
  start-page: 429
  year: 2007
  publication-title: Proc. Inst. Mech. Eng., Part H
– volume: 35
  start-page: 49
  year: 2014
  publication-title: Biomaterials
– volume: 34
  start-page: 746
  year: 2016
  publication-title: Trends Biotechnol.
– volume: 6
  start-page: 204
  year: 2011
  publication-title: Biotechnol. J.
– volume: 52
  start-page: 36
  year: 2019
  publication-title: Dent. J.
– volume: 29
  year: 2017
  publication-title: Adv. Mater.
– volume: 47
  start-page: 176
  year: 1929
  publication-title: Kolloid‐Z.
– volume: 9
  year: 2016
  publication-title: Biofabrication
– volume: 10
  year: 2018
  publication-title: Biofabrication
– volume: 16
  start-page: 1489
  year: 2015
  publication-title: Biomacromolecules
– volume: 6
  year: 2020
  publication-title: Sci. Adv.
– volume: 92
  start-page: 1262
  year: 2013
  publication-title: Carbohydr. Polym.
– volume: 20
  start-page: 22
  year: 2021
  publication-title: Nat. Mater.
– volume: 365
  start-page: 482
  year: 2019
  publication-title: Science
– volume: 4
  start-page: 1064
  year: 2017
  publication-title: Mater. Horiz.
– volume: 45
  start-page: 132
  year: 2017
  publication-title: Ann. Biomed. Eng.
– volume: 188
  start-page: 63
  year: 2019
  publication-title: Biomaterials
– volume: 11
  start-page: 48
  year: 2021
  publication-title: Theranostics
– volume: 115
  year: 2018
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 25
  start-page: 2603
  year: 2004
  publication-title: Biomaterials
– volume: 17
  start-page: 1393
  year: 2006
  publication-title: J. Mater. Sci.: Mater. Med.
– volume: 128
  start-page: 130
  year: 2021
  publication-title: Acta Biomater.
– volume: 31
  year: 2021
  publication-title: Adv. Funct. Mater.
– volume: 11
  start-page: 5130
  year: 2021
  publication-title: Sci. Rep.
– volume: 45
  start-page: 293
  year: 1992
  publication-title: J. Appl. Polym. Sci.
– volume: 23
  start-page: 1511
  year: 2002
  publication-title: Biomaterials
– volume: 24
  start-page: 1084
  year: 2013
  publication-title: J. Biomater. Sci., Polym. Ed.
– volume: 17
  start-page: 1976
  year: 2016
  publication-title: Int. J. Mol. Sci.
– volume: 1
  year: 2017
  publication-title: Adv. Biosyst.
– volume: 120
  year: 2020
  publication-title: Chem. Rev.
– volume: 32
  start-page: 8927
  year: 2011
  publication-title: Biomaterials
– volume: 9
  year: 2017
  publication-title: Biofabrication
– volume: 260
  year: 2020
  publication-title: Biomaterials
– volume: 26
  start-page: 318
  year: 2020
  publication-title: Tissue Eng., Part A
– volume: 2
  start-page: 2357
  year: 2014
  publication-title: J. Mater. Chem. B
– volume: 8
  start-page: 400
  year: 2017
  publication-title: Nat. Commun.
– volume: 11
  year: 2019
  publication-title: Biofabrication
– volume: 17
  start-page: 2137
  year: 2016
  publication-title: Biomacromolecules
– volume: 30
  start-page: 5910
  year: 2009
  publication-title: Biomaterials
– ident: e_1_2_9_27_1
  doi: 10.1111/j.1525-1594.2010.01193.x
– volume: 52
  start-page: 36
  year: 2019
  ident: e_1_2_9_45_1
  publication-title: Dent. J.
  doi: 10.20473/j.djmkg.v52.i1.p36-40
– ident: e_1_2_9_6_1
  doi: 10.1021/acs.chemrev.0c00008
– ident: e_1_2_9_57_1
  doi: 10.3390/polym14020354
– ident: e_1_2_9_26_1
  doi: 10.3390/su10082776
– ident: e_1_2_9_31_1
  doi: 10.1088/1758-5090/aadf58
– ident: e_1_2_9_35_1
  doi: 10.1016/j.biomaterials.2016.01.019
– ident: e_1_2_9_29_1
  doi: 10.1073/pnas.1811296115
– ident: e_1_2_9_4_1
  doi: 10.1088/1758-5090/8/1/013001
– ident: e_1_2_9_28_1
  doi: 10.1371/journal.pone.0235052
– ident: e_1_2_9_49_1
  doi: 10.1016/j.biomaterials.2003.09.046
– ident: e_1_2_9_56_1
  doi: 10.1088/1758-5090/aacdc7
– ident: e_1_2_9_20_1
  doi: 10.1038/s41467-017-00543-2
– ident: e_1_2_9_68_1
  doi: 10.1002/biot.201000340
– ident: e_1_2_9_76_1
  doi: 10.1016/j.actbio.2005.07.009
– ident: e_1_2_9_16_1
  doi: 10.1039/C7MH00269F
– ident: e_1_2_9_69_1
  doi: 10.1038/s41563-020-00803-5
– ident: e_1_2_9_23_1
  doi: 10.1002/smll.202202196
– ident: e_1_2_9_11_1
  doi: 10.1038/nrcardio.2016.170
– ident: e_1_2_9_77_1
  doi: 10.1243/09544119JEIM288
– ident: e_1_2_9_3_1
  doi: 10.1126/science.aav9051
– ident: e_1_2_9_15_1
  doi: 10.1088/1758-5090/9/1/012001
– ident: e_1_2_9_64_1
  doi: 10.1088/1758-5090/aa8dd8
– ident: e_1_2_9_61_1
  doi: 10.1002/app.1992.070450211
– ident: e_1_2_9_18_1
  doi: 10.1016/j.biomaterials.2020.120281
– ident: e_1_2_9_5_1
  doi: 10.1063/1.5059393
– ident: e_1_2_9_71_1
  doi: 10.1016/j.msec.2020.111701
– ident: e_1_2_9_73_1
  doi: 10.1002/adbi.201700043
– ident: e_1_2_9_17_1
  doi: 10.1088/1758-5090/aa8114
– ident: e_1_2_9_55_1
  doi: 10.1016/j.mtbio.2020.100058
– ident: e_1_2_9_72_1
  doi: 10.1007/s10856-006-0615-7
– ident: e_1_2_9_12_1
  doi: 10.1007/s10439-016-1653-z
– ident: e_1_2_9_9_1
  doi: 10.1021/acs.chemrev.0c00084
– ident: e_1_2_9_37_1
  doi: 10.1021/acs.biomac.5b00188
– ident: e_1_2_9_65_1
  doi: 10.1089/ten.tea.2019.0298
– ident: e_1_2_9_7_1
  doi: 10.1088/1758-5090/ab6034
– ident: e_1_2_9_22_1
  doi: 10.1002/adfm.202010104
– ident: e_1_2_9_60_1
  doi: 10.1002/(SICI)1097-4636(199910)47:1<46::AID-JBM6>3.0.CO;2-N
– ident: e_1_2_9_42_1
  doi: 10.1016/j.actbio.2021.04.016
– ident: e_1_2_9_58_1
  doi: 10.1016/j.biomaterials.2013.09.078
– ident: e_1_2_9_63_1
  doi: 10.1088/1758-5090/ab94cf
– ident: e_1_2_9_50_1
  doi: 10.1021/acsbiomaterials.8b00416
– ident: e_1_2_9_48_1
  doi: 10.1016/j.biomaterials.2012.01.007
– ident: e_1_2_9_53_1
  doi: 10.1016/j.biomaterials.2018.09.044
– ident: e_1_2_9_78_1
  doi: 10.1038/nmeth.2019
– ident: e_1_2_9_1_1
  doi: 10.1126/sciadv.aba7406
– ident: e_1_2_9_44_1
  doi: 10.1152/ajpcell.1996.271.3.C742
– ident: e_1_2_9_30_1
  doi: 10.1039/C3TB21462A
– ident: e_1_2_9_38_1
  doi: 10.1007/s10439-016-1704-5
– ident: e_1_2_9_40_1
  doi: 10.1088/1758-5090/ab331e
– ident: e_1_2_9_52_1
  doi: 10.1007/s40137-018-0198-5
– ident: e_1_2_9_43_1
  doi: 10.1016/S0142-9612(01)00281-2
– ident: e_1_2_9_51_1
  doi: 10.1007/BF01496959
– ident: e_1_2_9_33_1
  doi: 10.1088/1758-5090/aa8cb7
– ident: e_1_2_9_70_1
  doi: 10.1111/j.1525-1594.2005.00137.x
– ident: e_1_2_9_36_1
  doi: 10.1002/term.1682
– ident: e_1_2_9_66_1
  doi: 10.1038/s41598-021-84384-6
– ident: e_1_2_9_8_1
  doi: 10.1088/1758-5090/ab5158
– ident: e_1_2_9_21_1
  doi: 10.1088/1758-5090/ab39c5
– ident: e_1_2_9_14_1
  doi: 10.1016/j.tibtech.2016.03.004
– ident: e_1_2_9_13_1
  doi: 10.1038/s43246-021-00165-8
– ident: e_1_2_9_34_1
  doi: 10.1021/acs.biomac.6b00366
– ident: e_1_2_9_46_1
  doi: 10.1080/02652039109373974
– ident: e_1_2_9_75_1
  doi: 10.1016/j.joca.2003.08.006
– ident: e_1_2_9_47_1
  doi: 10.1080/09205063.2012.735100
– ident: e_1_2_9_10_1
  doi: 10.3390/bioengineering7020032
– ident: e_1_2_9_19_1
  doi: 10.7150/thno.50794
– ident: e_1_2_9_24_1
  doi: 10.1002/adma.202109394
– start-page: 15
  volume-title: Osteoporosis and Osteoarthritis. Methods in Molecular Biology
  year: 2021
  ident: e_1_2_9_79_1
  doi: 10.1007/978-1-0716-0989-7_2
– ident: e_1_2_9_41_1
  doi: 10.3390/ijms17121976
– ident: e_1_2_9_74_1
  doi: 10.1016/j.biomaterials.2011.08.027
– ident: e_1_2_9_54_1
  doi: 10.1016/j.actbio.2022.03.009
– ident: e_1_2_9_39_1
  doi: 10.3390/app11177821
– ident: e_1_2_9_67_1
  doi: 10.1016/j.biomaterials.2009.06.034
– volume-title: Theoretical stiffness limits of 4D printed self‐folding metamaterials
  year: 2021
  ident: e_1_2_9_62_1
– ident: e_1_2_9_25_1
  doi: 10.1002/adma.201703443
– ident: e_1_2_9_32_1
  doi: 10.1016/j.carbpol.2012.10.028
– ident: e_1_2_9_59_1
  doi: 10.1016/j.biomaterials.2010.04.045
– ident: e_1_2_9_2_1
  doi: 10.1016/j.biomaterials.2017.03.026
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Snippet 3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting,...
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage e2201891
SubjectTerms 3-D printers
4D bioprinting
Alginates
Alginates - chemistry
Alginic acid
biofabrication
Bioprinting
Bone marrow
Cartilage
Cell viability
Cellular structure
Flat surfaces
Histology
Humans
Hyaluronic Acid
Hydrogels
Inks
Mesenchymal Stem Cells
Mesenchyme
Multilayers
Printing, Three-Dimensional
Radius of curvature
Scaffolds
shape‐change
smart bioinks
Stromal cells
Swelling
Three dimensional printing
Time dependence
Tissue Engineering
Tissue Scaffolds - chemistry
Tyramine
Title Swelling‐Dependent Shape‐Based Transformation of a Human Mesenchymal Stromal Cells‐Laden 4D Bioprinted Construct for Cartilage Tissue Engineering
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadhm.202201891
https://www.ncbi.nlm.nih.gov/pubmed/36308047
https://www.proquest.com/docview/2765223216
https://www.proquest.com/docview/2730320857
https://pubmed.ncbi.nlm.nih.gov/PMC11468569
Volume 12
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