X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)₂ molecules by a bis(9-aminoacridine-4-carboxamide) derivative

• Published in: Nucleic acids research Vol. 34; no. 22; pp. 6663 - 6672
• Main Authors: Hopcroft, Nicholas H, Brogden, Anna L, Searcey, Mark, Cardin, Christine J
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2006; Oxford Publishing Limited (England)
• Subjects: Acridines - chemistry; Base Sequence; chemical elements; Cross-Linking Reagents - chemistry; crosslinking; crystal structure; Crystallography, X-Ray; cytotoxicity; Deoxyribonucleic acid; DNA; DNA - chemistry; guanine; hydrogen bonding; Intercalating Agents - chemistry; Ligands; Models, Molecular; neoplasm cells; Nucleic Acid Conformation; Strontium - chemistry; Structural Biology; X-ray diffraction

Acridine-4-carboxamides form a class of known DNA mono-intercalating agents that exhibit cytotoxic activity against tumour cell lines due to their ability to inhibit topoisomerases. Previous studies of bis-acridine derivatives have yielded equivocal results regarding the minimum length of linker nec...